Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 55 6 2017 08 19 354 359 EN Amin Shahrokhi Pediatric Neurorehabilitation Research Center, The University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. AND Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Ameneh Zare-Shahabadi Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Mohammad Naeimi Poor Noor Afshar Hospital, Iranian Red Crescent Society, Tehran, Iran. Firouzeh Sajedi Pediatric Neurorehabilitation Research Center, The University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Samaneh Soltani Molecular Immunology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Samaneh Zoghi Department of Immunology, School of Medicine, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Vienna, Austria. Reza Shervin Badv Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Mahmoud Reza Ashrafi Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Nima Rezaei Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, UK. 2016 06 15 2017 06 14 Inflammatory elements and genetics have major roles in febrile seizures (FS) pathogenesis. Seventy patients were enrolled and compared with 139 controls. The allele and genotype frequency of the IL-2 gene at -330 and +166 positions and the IFN-γ at +874 position were determined. A significant positive association with GG genotype at position -330 in the patient group was found (P=0.003). Further, a positive association was detected in simple and complex FS groups at the same position (P=0.03, P=0.004). IL-2 GT haplotype was significantly more common in the patients compared to controls (P=0.0008). Higher frequency of GT haplotype was detected in simple FS patients in comparison to controls (P=0.0003). Contrary, IL-2 TG haplotype frequency was lower in complex FS group (P=0.005). Overrepresentation of certain alleles, genotypes and haplotypes in IL-2 gene in FS patients could predispose individuals to this disease. https://acta.tums.ac.ir/index.php/acta/article/view/5713 https://acta.tums.ac.ir/index.php/acta/article/download/5713/4945