Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 55 9 2017 10 30 594 596 EN Hojat Eftekhari Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Kaveh Gharaei Nejad Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Seyyede Zeinab Azimi Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Rana Rafiei Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Alireza Mesbah Razi Clinico-Pathology Laboratory, Rasht, Iran. 2016 06 15 2017 03 21 Bowen's disease (BD) is an epidermal in-situ squamous cell carcinoma (SCC). Most Human Papilloma Viruses (HPV)-positive lesions in Bowen's disease are localized to the genital region or distal extremities (periungual sites) in which HPV type-16 is frequently detected. Patient was a 64-year-old construction worker for whom we detected 2 erythematous psoriasiform reticular scaly plaques on peri-umbilical and medial knee. Biopsy established the diagnosis of Bowen's disease and polymerase chain reaction assay showed HPV-6, -18 co-infection. Patient was referred for surgical excision. https://acta.tums.ac.ir/index.php/acta/article/view/5714 https://acta.tums.ac.ir/index.php/acta/article/download/5714/4993