Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 55 8 2017 10 07 482 485 EN Meletios Kanakis Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece. Aristeides Vaiopoulos Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greec. George Vaiopoulos Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece. Phaedon Kaklamanis Department of Rheumatology, Athens Medical Center, Athens, Greece. 2016 08 04 2017 04 13  Behçet’s disease is a chronic, recurrent, inflammatory disorder characterized by orogenital ulcers and skin lesions; serious manifestations also include ocular, large vessel, gastrointestinal and neurological involvement. Genetic and unknown environmental factors modify the wide clinical spectrum of the disease. During the long clinical course of the disease, testicular and epididymal involvement has been reported, with scrotal pain and swelling being the most common symptoms. In this review, we discuss the various aspects of epididymo-orchitis in Behcet’s disease patients, and we evaluate the diagnostic approaches as well as the empirical therapeutic modalities of this entity.   https://acta.tums.ac.ir/index.php/acta/article/view/5798 https://acta.tums.ac.ir/index.php/acta/article/download/5798/4970