Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 55 9 2017 10 30 578 584 EN Ahmad Amouzeshi Department of Cardiovascular Surgery, Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran. AND Surgery and Trauma Research Center, Birjand University of Medical Sciences, Birjand, Iran. Zahra Amouzeshi Surgery and Trauma Research Center, Birjand University of Medical Sciences, Birjand, Iran. AND Department of Nursing, Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran. Mohammad Abbasi Teshnizi Department of Cardiac Surgery, Atherosclerosis Prevention Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Ali Asghar Moeinipour Department of Cardiac Surgery, Atherosclerosis Prevention Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Mahmood Hosseinzadeh Maleki Department of Cardiovascular Surgery, Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran. AND Surgery and Trauma Research Center, Birjand University of Medical Sciences, Birjand, Iran. 2016 09 05 2017 04 15 Given the ongoing controversy over the risks and benefits of on-pump versus off-pump coronary artery bypass graft surgery (CABG), we aimed to compare time trends in off- and on-pump CABG long-term outcomes. In this prospective cohort study, the patients who underwent primary isolated non-emergent CABG in Imam Reza Hospital in Mashhad, Iran, in 2006 were followed for 6 years. The patients were contacted to obtain long-term follow-up data such as death, rehospitalization, myocardial infarction, and normal physical activity. The obtained data were analyzed in SPSS software (V: 16) using t-test, Fisher's Exact, chi-square, and Mann-Whitney tests, and relative risk. The significant level was set at P<0.05.The study included 61 patients of whom n=40 (65.6%) underwent off-pump CABG. The mean age of the patients was 59.0±11.31 years, and n=43 (70.5%) were men. No significant differences were found between the two groups in terms of outcomes during the 6 years (e.g., death, rehospitalization, myocardial infarction, and normal physical activity). There was 1 (5.0%) death, overall. Risk-adjusted death did not differ significantly between the off-pump and on-pump groups during the 6 years (RR, 0.952; 95% CI 0.866 to 1.048).According to the results, the outcomes were similar between off-pump and on-pump CABG in patients who underwent primary isolated non-emergent CABG during the 6-year follow-up phase. https://acta.tums.ac.ir/index.php/acta/article/view/5864 https://acta.tums.ac.ir/index.php/acta/article/download/5864/4990