Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 55 5 2017 07 11 333 339 EN Raika Jamali Research Development Center of Sina Hospital, Digestive Diseases Research Institute, IBD Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Biglari Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Seyyed Vahid Seyyed Hosseini Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ali Shakouri Rad Department of Radiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Farid Kosari Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2016 12 29 2017 01 31 To evaluate the association between disease severity and hepatic steatosis in patients with ulcerative colitis (UC) and non-alcoholic steatohepatitis (NASH). Consecutively selected UC patients admitted to the gastroenterology clinic were enrolled in the study. UC severity was assessed by Truelove and Witts classification. Patients with severe UC were excluded from the study. NASH was determined based on persistently elevated serum aminotransferase levels and detection of fatty liver ultrasound. Patients with other etiologies for elevated aminotransferase levels were excluded. Liver fat content (LFC) was assessed by measuring liver fat score (LFS). One hundred patients (42% male) were included in the study. According to liver ultrasound examination, 62 (%) patients were identified with grade 1 fatty liver disease, and 38 (%) patients were classified as advanced (grade 2 and 3) fatty liver disease. Sixty-one patients had left-sided UC and (46%) had mild UC disease severity index. LFS was significantly higher in UC patients with the moderate disease than patients with mild disease (3.53±2.68 vs. 5.89±2.85, respectively; P<0.01). Nevertheless, no significant difference was observed in LFS regarding UC extension. There was no significant difference between NASH ultrasound grades in view of UC severity and extension. LFC might be associated with UC severity. https://acta.tums.ac.ir/index.php/acta/article/view/6094 https://acta.tums.ac.ir/index.php/acta/article/download/6094/4940