Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 56 8 2018 11 26 547 550 EN Saeed Almasi Department of Radiotherapy, AJA University of Medical Sciences, Tehran, Iran. Fereshteh Ensani Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Alireza Abdollahi Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2017 05 02 2017 12 18 Seventy-five percent of salivary gland tumors occur in parotid tumors. These tumors are mainly (75% to 85%) benign and around 25% turn out to be malignant. The most common cases of malignancy are mucoepidermoid carcinoma and adenoid cystic carcinoma (they totally represent half of the malignant tumors). Acinic cell carcinoma (ACC) is not of high incidence and is often seen in major salivary glands, particularly parotid gland. ACC makes up for 1-3% of salivary gland tumors and 3% of total parotid tumors. It is a low-grade malignant tumor with metastatic and invasive ability. Advanced stage, painful and fixed tumor, desmoplasia, anaplasia and differential character of the tumor, high mitosis, and necrosis, and nerve invasion, incomplete removal of the tumor, large size, and invasion to the deeper lobe of parotid worsen the prognosis of this tumor. We present a case report of a 52-year-old man with ACC metastasis to superior left humerus 15 years after surgery. https://acta.tums.ac.ir/index.php/acta/article/view/6418 https://acta.tums.ac.ir/index.php/acta/article/download/6418/5144