Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 56 3 2018 03 06 196 203 EN Mohsen Sedighiyan Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Mina Abdolahi Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. AND Marvasti Obesity Institute, Amir Alam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Ehsaneh Taheri Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Mostafa Qorbani Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Parisa Omidian ENT Research Center, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Saeed Hosseini Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. AND Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. 2017 05 24 2017 12 18 Metabolic syndrome is a cluster of conditions which enhance the risk of metabolic and cardiovascular diseases such as diabetes mellitus, dyslipidemia, or hypertension. Obesity plays a pivotal role in the pathogenesis of metabolic syndrome. French maritime Pine bark extract (PBE) in addition to its antioxidant properties, has protective effects on metabolic syndrome component through several mechanisms. At present, there are few data on the net impact of PBE on metabolic syndrome factors in obesity. This trial report the results of 2-month period supplementation of 38 obese women received weight loss diet and PBE (150mg/day) or placebo. The metabolic syndrome parameters and body composition were assessed at the beginning and end of the study. The results showed PBE has significant protective effects on metabolic syndrome factors including central obesity, TG, HDL, BP and FBS (P<0.05), decrease metabolic syndrome risk in obesity and improve body composition. Thus, The PBE is considered as a new approach to obesity and metabolic syndrome prevention. https://acta.tums.ac.ir/index.php/acta/article/view/6480 https://acta.tums.ac.ir/index.php/acta/article/download/6480/5068