Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 56 10 2019 01 13 681 683 EN Christos Kakos Department of Thoracic Surgery, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK. Sofoklis Mitsos Department of Thoracic Surgery, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK Nikolaos Madouros Department of Thoracic Surgery, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK Davide Patrini Department of Thoracic Surgery, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK. Reena Khiroya Department of Cellular Pathology, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK. Elaine Borg Department of Cellular Pathology, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK. David Lawrence Department of Thoracic Surgery, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK. Nikolaos Panagiotopoulos Department of Thoracic Surgery, University College London Hospitals (UCLH) NHS Foundation Trust, London, UK 2017 11 10 2017 12 23 Schwannoma is a benign encapsulated tumor of the nerve sheath. Amongst other sites, it develops in the posterior mediastinum in the costovertebral sulcus. We herein present a case of a 68-year-old woman with an incidental finding of a subcarinal mass. Radiological and histopathological studies were suggestive of schwannoma. Therefore, the mass was completely resected through a right thoracotomy, and a definite histopathological diagnosis was established. Although the subcarinal area is a rare site for this tumor to appear, the schwannoma should be considered as part of the differential diagnosis of lesions in the subcarinal region. Treatment of choice is the nerve-sparing surgical excision of the mass with excellent prognosis. A review of the literature on this topic was performed. https://acta.tums.ac.ir/index.php/acta/article/view/6839 https://acta.tums.ac.ir/index.php/acta/article/download/6839/5175