Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 56 10 2019 01 12 625 634 EN Javad Fahanik-Babaei Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Tourandokht Baluchnejadmojarad Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Farnaz Nikbakht Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mehrdad Roghani Neurophysiology Research Center, Shahed University, Tehran, Iran. 2017 12 06 2018 11 13 - Intrahippocampal amyloid β (Aβ) negatively affects synaptic plasticity with subsequent impairment of learning and memory. Trigonelline is an alkaloid commonly found in fenugreek seeds and coffee beans with neuroprotective property and a promising agent for management of neurodegenerative disorders like Alzheimer’s disease (AD). In the present study, the possible beneficial effect of trigonelline on the improvement of learning and memory and synaptic plasticity was evaluated in Aβ (1-40) rat model of AD. For modeling AD, aggregated A https://acta.tums.ac.ir/index.php/acta/article/view/6874 https://acta.tums.ac.ir/index.php/acta/article/download/6874/5166