Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 4 2019 07 13 262 266 EN Mansour Moghimi Department of Pathology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Amir Aryanfar School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Hassanali Vahedian-Ardakani Department of Hematology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Fatemeh Joukar School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2018 02 28 2018 12 15 Secondary scrotal tumors originating from viscera are rare and indicate a poor prognosis. We report a patient who underwent abdominoperineal resection due to his rectal cancer. Tumor recurrence at the surgical site led to prostate involvement. About 1 month after the prostatectomy, scrotal skin metastasis presented as bilateral papulonodular lesions. Finally, brain metastasis occurred and caused his death. Also, several ways by which malignancies can metastasize to scrotum have been discussed. https://acta.tums.ac.ir/index.php/acta/article/view/7076 https://acta.tums.ac.ir/index.php/acta/article/download/7076/5248