Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 3 2019 05 13 200 204 EN Mansour Moghimi Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Amir Aryanfar School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Saeed Kargar Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Fatemeh Joukar School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2018 02 28 2018 11 05 We report two cases of pleomorphic breast carcinoma, a rare variant of high-grade invasive ductal breast carcinoma of no special type, which is a combination of pleomorphic and bizarre giant cells in an adenocarcinoma background. For gaining better insights, available literature is also reviewed. https://acta.tums.ac.ir/index.php/acta/article/view/7080 https://acta.tums.ac.ir/index.php/acta/article/download/7080/5238