Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 5 2019 09 30 332 334 EN Arsalan Azizi Department of Pathology, Imam Sajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran. Moslem Sedaghattalab Department of Internal Medicine, Imam Sajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran. 2018 03 05 2021 08 06 Reye's syndrome (RS) is a rare disease, usually associated with consumption of salicylates during viral illness. In 1965, the first case of association between RS and salicylates was described in United Kingdom (UK). The incidence of RS decreased dramatically after warnings of UK and US health agencies against using aspirin in children. Patients with RS presented with neurologic compromise, cerebral edema, acute hepatitis, and liver failure-especially in the children.  In this paper, a four-month-old boy with diagnosis of RS was described, who presented with malaise, cyanosis and decreased level of consciousness, but the history of salicylates consumption was negative for him and his mother. https://acta.tums.ac.ir/index.php/acta/article/view/7089 https://acta.tums.ac.ir/index.php/acta/article/download/7089/5269