Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 2 2019 03 12 116 121 EN Shokoufeh Hajsadeghi Department of Cardiology, Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. Yaghoub Bagheri Department of Cardiology, Shahid Rajaei Heart Hospital, Iran University of Medical Sciences, Tehran, Iran. Mohammad Hossein Ghafouri Department of Medicine, Iran University of Medical Sciences, Tehran, Iran. Scott Reza Jafarian Kerman Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Morteza Hassanzadeh Department of Internal Medicine, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. 2018 03 05 2018 12 15 Patients with heart failure (HF) are frequently admitted for episodes of decompensation. Cardiac troponins are easily accessible biomarkers role of which for risk stratification of re-hospitalization among HF patients is less certain. We aimed to evaluate high-sensitive cardiac troponin I (hs-cTnI) levels among re-hospitalized patients with decompensated heart failure (D-HF). Consecutive subjects admitted with D-HF to 2 hospitals in Tehran, during the year 2014 were recruited. Excluded ones were patients with a suspected acute coronary syndrome or myocarditis/pericarditis, those with cardiopulmonary resuscitation/DC shock delivery, or major complications during or after hospitalization. Along with echocardiography parameters, level of hs-cTnI was checked at the first hour of hospitalization and 3 months after discharge. The patients were then categorized according to having or not having re-hospitalization during 3 months post discharge. A total of 97 patients were finally recruited. Among re-hospitalized patients, Left ventricular (LV) ejection fraction was significantly lower (38±14 % vs. 50 ± 12%; P=0.001), and LV end-systolic dimension was significantly higher (44±9 mm vs. 38±11 mm; P=0.012) compared to the other group. Moreover, levels of hs-cTnI were significantly higher among the re-hospitalized patients, both at initial visit (0.66±0.43 ng/ml vs 0.51±0.14 ng/ml, respectively; P=0.017) and at 3 months (0.59±0.48 ng/ml vs 0.48±0.23 ng/ml, respectively; P=0.030). This prospective study demonstrated that levels of hs-cTnI (both at the base and at follow up) are higher among patients who readmitted during 3 months of hospitalization for D-HF. https://acta.tums.ac.ir/index.php/acta/article/view/7090 https://acta.tums.ac.ir/index.php/acta/article/download/7090/5220