Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 56 9 2018 12 25 604 612 EN Negisa Seyyedi National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran. Mehran Maghsoudloo National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran. 2018 06 25 2018 08 10 The nursing profession generates a large number of documents, and despite a number of terminology standards in existence, lack of interoperability in process and data structure still persists. The purpose of carrying out this study was to develop an integrated, comprehensive structure of nursing process as a domain information model which could be suitable for message development which potentially can be used when implementing clinical information software. We present phases of nursing process modeling, followed by mapping the resultant model to the HL7 Reference Information Model, generating a nursing domain message information model. Also, reviewing the Clinical Document Architecture in relation to the nursing process, we present our proposal for changes required to its object model for better support of nursing documents. https://acta.tums.ac.ir/index.php/acta/article/view/7338 https://acta.tums.ac.ir/index.php/acta/article/download/7338/5160