Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 4 2019 07 13 254 261 EN Omid Zargari Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Seyyede Zeinab Azimi Department of Dermatology, Skin Research Center, Guilan University of Medical Sciences, Rasht, Iran. Tara Barat Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Vahide Lajevardi Department of Dermatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ehsan Kazemnezhad Department of Biostatistics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Mohammad Shahidi Dadras Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2018 10 15 2018 12 28 Psoriasis is a common chronic inflammatory skin disease, which is gradually being recognized as a systemic inflammatory disorder. Psoriasis and obesity are strongly linked, but there is not enough data whether obese psoriatic patients present differently from non-obese psoriatic patients. To compare the phenotype, clinical features, severity, baseline comorbidities and laboratory findings among psoriatic patients with/without obesity all the psoriatic patients, from three centers, who were receiving systemic therapy were included in the study. Patients were divided into two groups: those with obesity and those without obesity. We included 497 patients: 154 (31%) patients were obese and 343 (69%) were non-obese. Obese patients had more comorbidities, particularly hyperlipidemia, followed by hypertension and diabetes. Fasting blood sugar and serum lipids were significantly higher among obese subjects. Given the differences between obese patients and non-obese patients, the former group should be followed and managed more closely and with specific attention.. https://acta.tums.ac.ir/index.php/acta/article/view/7532 https://acta.tums.ac.ir/index.php/acta/article/download/7532/5246