Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 5 2019 09 30 320 327 EN Abolfazl Ghoreishi Department of Psychiatry, Social Determinant of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. AND Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Lila Dashtaki Department of Psychiatry, Shahid Beheshti Hospital, Zanjan University of Medical Sciences, Zanjan, Iran. Bahareh Hajisalimi Department of Internal Medicine, Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. 2018 12 29 2019 08 30 Sexual dysfunction is a common complication among male patients with chronic kidney disease. Common disturbances include erectile dysfunction, decreased libido, and infertility. Sexual dysfunction is a multifactorial problem, and the treatment options are limited, it associated with lower quality of life scores in patients. Chronic kidney disease also has a critically impairing effect on the quality of life. To investigate the efficacy of bupropion on sexual dysfunction and quality of life in men with chronic kidney disease, a single-blind placebo-controlled trial was conducted. A total of 40 male patients with chronic kidney disease suffering from erectile dysfunction (Mean age 41/25±8/8) were randomly assigned to receive 10 weeks of treatment with either bupropion or placebo. Sexual function and quality of life were assessed by IIEF5 and WHOQOL-BREF questionnaires, respectively. Baseline demographic and clinical features were similar in both groups. The results showed a significant difference between the intervention and control groups in sexual function (P=0/005) and total quality of life (P=0/001); also the difference was significant in physical health (P=0/012), psychological health (P<0/001) and social relationship (P<0/001) domains. Our findings suggest that Bupropion is effective and safe for treating sexual dysfunction in men with chronic kidney disease and also could positively affect the quality of life among the patients. https://acta.tums.ac.ir/index.php/acta/article/view/7649 https://acta.tums.ac.ir/index.php/acta/article/download/7649/5267