Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 6 2019 11 17 368 373 EN Abolfazl Mahyar Department of Pediatrics, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran. Shahrokh Mehrpisheh Department of Neonatology, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran. Bahman Khajeh Department of Neonatology, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran. Parviz Ayazi Department of Pediatrics, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran. Sonia Oveisi Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Shifteh Mahyar School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. Shiva Esmaeili Department of Statistics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. 2019 01 13 2019 10 20 This study was conducted to determine the effect of purgative Manna and clofibrate on unconjugated hyperbilirubinemia of term neonates. In this randomized clinical trial study, sixty neonates suffering from unconjugated hyperbilirubinemia were evaluated. The neonates were divided into three groups using balanced block randomization. Group A (control group-received only phototherapy), group B (intervention group-received purgative Manna and phototherapy) and group C (intervention group-received clofibrate and phototherapy). After the intervention, the amount of serum bilirubin reduction was compared between groups. There was no significant difference among group A, B, and C in terms of serum bilirubin reduction in 24, 48 and 72 hours after starting the intervention (P>0.05). The hospital stays in the control group was significantly longer than the intervention groups (P<0.05). No side effects were observed related to using purgative Mienna and clofibrate. The present study showed that prescribing of purgative Manna and clofibrate has no effect on reduction of serum bilirubin level in term neonates with unconjugated hyperbilirubinemia. Thus, it seems that the administration of these drugs is not necessary. Further studies in this regard are recommended. https://acta.tums.ac.ir/index.php/acta/article/view/7685 https://acta.tums.ac.ir/index.php/acta/article/download/7685/5276