Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 58 2 2020 06 29 56 63 Zaina Alazawi Department of Family Medicine, Ministry of Health, Amman, Jordan. Ola Alqudah Department of Family Medicine, Ministry of Health, Amman, Jordan. Ahmad Al-Bashaireh College of Nursing, Faculty of Nursing, Al-Ahliyya Amman University, Amman, Jordan. 2019 07 31 2020 04 24 The aims of this study are to determine the prevalence of sexual dysfunction and to examine the relationships of sexual function and psychological factors of depression and anxiety and diabetes-related factors in Jordanian women with type 2 diabetes mellitus. This study employed a cross-sectional, descriptive, correlational design. All eligible participants with type 2 diabetes mellitus were consequently recruited from primary care centers. All enrolled participants were asked to complete questionnaires: Arabic version of the Female Sexual Function Index, Beck Depression Inventory-II, Beck Anxiety Inventory, and demographic questionnaires. Physical and biological measures were collected from the patient's medical records. 107 women with type 2 diabetes mellitus were recruited with a mean of age of 52.46±8.38 years. The prevalence of female sexual dysfunction was 94.4%. Regarding the mean scores of the Arabic version of the Female Sexual Function Index domains, the highest mean score was for pain (5.09±1.51), and the lowest mean score was for sexual arousal (2.44±1.28). This study found significant inverse relationships between female sexual function and age (r= -0.340, P<0.01), duration of diabetes (r= -0.211, P=0.029), fasting blood sugar (r= -0.234, P=0.015), anxiety (r= -0.375, P<0.01), and depression (r= -0.480, P<0.01). Our study found female sexual dysfunction is widely prevalent in Jordanian women with type 2 diabetes mellitus (94.4%). There were significant correlations between anxiety, depression, and female sexual function among women with type 2 diabetes mellitus. https://acta.tums.ac.ir/index.php/acta/article/view/8024 https://acta.tums.ac.ir/index.php/acta/article/download/8024/5369