Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 6 2019 11 17 374 380 EN Mostafa Dastani Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Soheila Moshiri Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Ramin Khameneh Bagheri Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Maryam Bahramizadeh Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Ladan Hassanzadeh Khayyat School of Medicine, St. George’s University, Grenada, USA. Sepideh Elyasi Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Amir Hooshang Mohammadpour Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. AND Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2019 09 01 2019 09 08 The pathophysiology of coronary arteries slow flow phenomenon is related to the microvascular and endothelial disorder. The role of copper and selenium in the development of microvascular and endothelial disorders, as well as atherosclerosis, has been proven in previous studies. The aim of this study was to evaluate the serum copper and selenium concentrations in patient with coronary slow flow phenomenon to find a probable relationship between them. In this study, 125 patients who referred to Ghaem Hospital in Mashhad for angiography were selected based on entry and exit criteria. Patients were divided into 5 groups according to the results of angiography. Blood samples of these patients were evaluated about the levels of copper and selenium. Finally the correlation between these levels and the intensity of coronary arteries slow flow (based on TIMI scores) was evaluated. In the present study, serum selenium and copper concentrations did not show a significant correlation with the intensity of coronary arteries slow flow (P>0.05). In the present study, no significant correlation was found between copper and selenium serum concentrations and coronary arteries slow flow based on TIMI. Further studies are recommended to investigate this association.   https://acta.tums.ac.ir/index.php/acta/article/view/8056 https://acta.tums.ac.ir/index.php/acta/article/download/8056/5277