Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 58 3 2020 07 19 121 125 Maryam Hatami Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Arezoo Kheirati Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Shekoufeh Behdad Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Atiye Javaheri Departments of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Sedighe Vaziribozorg Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2019 10 26 2020 05 04 The purpose of this study was to evaluate the effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy. In this double-blind clinical trial study, 57 patients aged 18-55 years with ASA I or II undergoing laparoscopic myomectomy involved. The case group received oral duloxetine 60 mg, and the control group received placebo 2 hours before the surgery. Pain scores, total analgesic consumption during 24 hours, recovery discharging time, nausea, vomiting, dizziness, and hemodynamic changes were recorded and compared between two groups. The pain severity was significantly lower in the case group at 2, 12, and 24 hours after the operation (P<0.05). There were no significant differences in dizziness, nausea, vomiting, systolic and diastolic blood pressure, and heart rate of patients between two groups before the surgery, 5 and 30 minutes after the induction, and after the recovery. Duloxetine administration prior to laparoscopic surgery myomectomy can reduce postoperative pain without inducing side effects in patients. https://acta.tums.ac.ir/index.php/acta/article/view/8161 https://acta.tums.ac.ir/index.php/acta/article/download/8161/5382