Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 58 7 2020 10 18 301 309 Atefeh Ghahremanloo Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Fariba Mohammadi Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Seyed Isaac Hashemy Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2020 01 17 2020 05 02 Tachykinins (TKs) are a family of neuropeptides widely distributed in the human body, especially in the nervous system. TKs have exhibited both neuroprotective and neurodegenerative properties in the central nervous system (CNS) and spinal cord. Also, several studies have shown that substance P (SP), as a pioneering neuropeptide of the TK family, is engaged in the pathogenesis of neurodegenerative disorders (NDs), such as Alzheimer disease, Multiple Sclerosis, Parkinson’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis. However, a huge body of information available about the level of SP in NDs demonstrates that SP and its receptors might be prognostic or diagnostic factors for NDs. The present review article summarizes the roles of TKs in common neurodegenerative disorders. https://acta.tums.ac.ir/index.php/acta/article/view/8280 https://acta.tums.ac.ir/index.php/acta/article/download/8280/5418