Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 58 7 2020 10 18 358 361 Sanaz Mehrabani Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Javad Shokri-Shirvan Department of Internal Medicine, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran 2020 03 10 2020 05 05 Inflammatory myofibroblastic tumors (IMTs) are rare with unknown etiology. As pancreas involvement is rare in IMTs, here, we report a case of a girl with IMT, referred to our hospital. A 4-year-old girl presented with chief complaints of generalized itching and jaundice. Abdominopelvic computed tomography (CT) scans with contrast showed a homogeneous isodense mass lesion in the head of the pancreas with a compressive effect on the distal part of the common bile duct (CBD). Dilatation of intrahepatic bile ducts and CBD (8 mm) was observed. Magnetic resonance cholangiopancreatography (MRCP) examination showed a dilated gallbladder without stones and intrahepatic/extrahepatic bile ducts. The CBD was dilated, and a mass was found in the head of the pancreas. Immune-histochemical studies revealed spindle myofibroblastic tissues with lymphoplasmacytic and eosinophil infiltration. All of them were compatible with pancreatic IMTs. The surgery improved the symptoms. The IMTs of the pancreas can have symptoms like pancreatic cancer. The careful evaluation by imaging and pathology is recommended. https://acta.tums.ac.ir/index.php/acta/article/view/8352 https://acta.tums.ac.ir/index.php/acta/article/download/8352/5425