Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 11 2021 11 17 675 680 EN Bahar Saberzadeh-Ardestani Department of Gastroenterology, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran Majid Sorouri Department of Gastroenterology, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran Bardia Khosravi Department of Gastroenterology, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran Ali Reza Sima Department of Gastroenterology, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran Reza Malekzadeh Department of Gastroenterology, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran 2020 06 19 2021 09 10 An outbreak of COVID-19 started in December 2019 in the city of Wuhan and is now rapidly spreading across the world. We report two cases of confirmed COVID-19 with pre-existing comorbidities who were discharged from the hospital with a good clinical condition and in concordance with interim discharge protocols. However, they were readmitted and died on the discharge day. Here we discuss the importance of patient demographics in clinical management vs. the resolution of the pulmonary disease alone and raise a question about the impact of comorbidities on discharge protocols. https://acta.tums.ac.ir/index.php/acta/article/view/8551