Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 4 2022 04 19 202 209 Arun Kumar Pradhan Centre for Biotechnology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, India. Manoranjan Arakha Centre for Biotechnology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, India Binay Kumar Sahoo Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Debapriya Bhattacharya Centre for Biotechnology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, India. 2020 07 06 2021 11 08 The coronavirus disease 2019 (COVID-19) is a single-stranded RNA (+) virus and causes infectious disease by the viral strain "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). Now, COVID-19 has become pandemic, and there are neither potential vaccines nor drugs discovered. Its RNA contains genes for structural (S, E, M, N) and non-structural proteins (PLpro, 3CLpro, RdRp, Hel). Interaction between the S protein of SARS-CoV-2 and the ACE 2 receptor of the host cell plays a vital role in the entry of the virus into the cell. Favipiravir, ribavirin, remdesivir, galidesivir, lopinavir, ritonavir, chloroquine, and hydroxychloroquine are the few effective drugs against SARS-CoV-2. Live attenuated virus (mutant MERS-CoV and SARS-CoV or recombination with another live attenuated virus) can act as vaccine platforms against SARS CoV-2 along with DNA vaccine and subunit vaccine. https://acta.tums.ac.ir/index.php/acta/article/view/8604