Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 7 2021 08 25 393 399 Seyedreza Mirsoleymani School of Nursing, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand Erfan Taherifard Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Ehsan Taherifard Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Mohammad Hossein Taghrir Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Milad Ahmadi Marzaleh 3 Department of Health in Disasters and Emergencies, Health Human Resources Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. AND Health Human Resources Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Mahmoudreza Peyravi Department of Health in Disasters and Emergencies, Health Human Resources Research Center, Shiraz University ofMedical Sciences, Shiraz, Iran AND Health Human Resources Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Rita Rezaee Health Human Resources Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. AND Clinical Teaching Research Center, School of Health Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Seyyed Mojtaba Nekooghadam Internal Department of Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2020 07 22 2021 05 19 Background: late in 2019, the first case of COVID-19 was detected in China, and the disease caused pandemic state worldwide. Up to now, many studies investigated the impact of comorbid diseases, especially diabetes mellitus on COVID-19 outcomes. Objectives: In this study, we aimed to assess the para-clinic characteristics of COVID-19 patients with or without diabetes mellitus to identify factors indicative of poor prognoses. Methods: In this prospective study, 153 in-patients with COVID-19 were followed up from 1 March to 19 April. Paraclinical information of these patients was gathered from their medical records. Afterward, the association between these factors among both diabetic and non-diabetic patients were assessed in the correlation analyses. Results: discharge and expiration of 77.1% and 22.9% of the study participants resulted in a 1063 person-day follow up for patients who discharged healthily, and 384 person-day follow up for expired patients. 41.8% of the participants had diabetes mellitus. Lymphocytopenia and Neutrolhilia prevalences increased during hospitalization; comparing with their initial prevalences. Thirty-seven patients got acute respiratory distress syndrome; of those, 35 died. The mean of the initial C reactive protein level was 42.49 and serum creatinine of 1.39 Conclusion: The study showed that higher initial neutrophil count, increasing neutrophil count more than 15000 and decreasing lymphocyte count below 1000 during hospitalization; development of acute respiratory distress syndrome and being intubated; initial C reactive protein and serum creatinine level were associated with higher mortality rates in COVID-19 victims. https://acta.tums.ac.ir/index.php/acta/article/view/8655