Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 2 2022 02 23 129 131 Ghasem Miri-Aliabad Department of Pediatric Hematology-Oncology, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Hamid Dahmardeh Department of Radiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mohammad Saleh Rajabi Department of Radiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 2020 07 24 2021 12 07 We describe the case of a 7-year-old boy who presented with suprasternal swelling. The chest computed tomography scan showed a large mass of mediastinum. Biopsy from the mediastinal mass was performed. Histologic and immunohistochemistry findings were consistent with Langerhans cell histiocytosis [LCH]. LCH should also be considered in the differential diagnosis of anterior mediastinal tumor in children. https://acta.tums.ac.ir/index.php/acta/article/view/8663