Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 2 2021 02 28 122 124 Hossein Aghaei Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Acieh Es'haghi Department of Ophthalmology, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sanam Alilou Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Shirin Rafatnia Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2020 08 06 2021 01 31 We describe a 34-year-old woman with isolated tuberculosis (TB) uveitis who had unsuccessful resolution of her ocular surface squamous neoplasia after multiple shave excisions with a positive purified protein derivative (PPD) test and interferon-gamma (IFN-γ) release assays (IGRAs) proven tuberculosis. She was managed with wide local excision of the lesion. Histopathology confirmed conjunctival intraepithelial neoplasia (CIN) grade II. Topical interferon alpha-2b (4 times daily) and anti-tuberculous therapy was planned for her, and there was no sign of recurrence of the lesion at six months follow-up. https://acta.tums.ac.ir/index.php/acta/article/view/8704