Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 5 2022 06 08 313 315 Sahel Valadan Tahbaz Clinical Cancer Research Center, Milad General Hospital, Tehran, Iran Hossein Yahyazadeh Clinical Cancer Research Center, Milad General Hospital, Tehran, Iran Saadat Molanaei Clinical Cancer Research Center, Milad General Hospital, Tehran, Iran Marziyeh Beheshti Clinical Cancer Research Center, Milad General Hospital, Tehran, Iran 2020 08 12 2021 12 08 SCC of the prostate is different from other adenocarcinomas in its treatment and prognosis. Here, the patient is a 57-year-old man with benign prostatic hyperplasia that underwent a prostatectomy and, after one month with hematuria and another follow-up radical cystoprostatectomy with lymphadenectomy and urethrectomy. After recovery, the patient experienced radiotherapy and chemotherapy sessions. So, from a review of other literature, we present our case report of squamous cell carcinoma of the prostate that is more aggressive than adenocarcinoma. https://acta.tums.ac.ir/index.php/acta/article/view/8725