Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 1 2021 02 08 44 49 Mohammad Meskarpour-Amiri Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Parisa Mehdizadeh Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Maryam Yaghoubi Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Sayyed Morteza Hosseini Shokouh Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Taha Nasiri Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Babak Hassanlouei Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Hossein Amini Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran 2020 08 26 2020 10 13 This study aimed to evaluate the effect of macro-level health policies on COVID-19 outbreak control in Iran. This was a descriptive-analytical study of the applied time series performed on April 19, 2020. The effect of four macro-health interventions, including reducing overcrowding, social distancing, limitation of high-risk economic activities, and active case detection, was examined. The Vector auto-regression (VAR) was used to investigate the effect of the interventions. The augmented Dickey-Fuller test (ADF) was used to ensure the time stability of the time series and the existence of a unit-root. To analyzing data and estimation VAR models, STATA software was used. P of less than 0.1 was considered significant. The increase in the number of cases with two days’ lag had a positive and significant effect on increasing the number of new cases of the COVID-19 (C=0.176, P=0.097). Adopting an overcrowding reduction policy with both 2-day lags (c=0.095, P=0.066) and 4-day lags (c=0.314, P=0.000) had a negative and significant effect on increasing the number of new cases of the COVID-19. Our study showed that overcrowding reduction and new COVID-19 case detection could play an effective role in controlling the epidemic of COVID-19 in Iran. It seems that the best advice is to stay home and use strategies to identify more patients. https://acta.tums.ac.ir/index.php/acta/article/view/8755