Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 61 2 2023 04 17 109 114 Alireza Kamali Department of Anesthesiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran Ali Chehrei Clinical Research Development Unit of Ayatollah Khansari Hospital, Arak University of Medical Sciences, Arak, Iran Mohammad Hasanian Department of Radiology, Arak University of Medical Sciences, Arak, Iran. Masoomeh Sofian Infectious Disease Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran. Masoud Bahrami Infectious Disease Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran. Behzad Khansarinejad Department of Microbiology and Immunology, Arak University of Medical Sciences, Arak, Iran Nader Zarinfar Department of Infectious Disease, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Rahmatollah Moradzadeh Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran Hosein Sarmadian Department of Infectious Disease, School of Medicine, Arak University of Medical Sciences, Arak, Iran Fateme Safi Department of Radiology and Radiotherapy, School of Medicine, Arak University of Medical Sciences, Arak, Iran 2020 12 04 2023 01 15 Novel coronavirus disease 2019 (COVID-19) has become a public health concern with over 6.5 million cases and 390,000 deaths around the world. This research aimed to find an association between computed tomography (CT) scores and clinical and laboratory findings to estimate the extent of lung infection in patients with COVID-19. The study sample enrolled 129 patients diagnosed with COVID-19 from January to February 2020. The chest CT images and clinical data were reviewed, images were segmented and scored by the degree of involvement from 0 to 4, and the relationship between them and clinical and laboratory findings were analyzed statistically. This study included 74 men and 59 women with a mean age of 55.08 years. Different abnormalities were observed; the mean CT score was 8.52 (7.83 to 9.21) and the most frequent lesions were GGO and consolidation. Our results revealed significant differences between groups categorized by dyspnea, sore throat, and low oxygen saturation concerning CT scores. There was also a significant correlation between CT scores and WBC counts and CRP levels (P<0.05). The evidence from this study implies that clinical and laboratory data, such as CRP, dyspnea, lymphopenia, and symptom onset closely correspond to chest CT scores and may be employed as initial tools to estimate the extent of lung involvement in COVID-19 patients.   https://acta.tums.ac.ir/index.php/acta/article/view/8992