Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 12 2021 12 15 740 742 Mahya Shabani Students' Research Committee, Tehran University of Medical Sciences, Tehran, Iran Besharat Rahimi Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran Mohammad Mehdi Mehrabi Nejad Department of Radiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Reza Erfanian Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Arezoo Najafi Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran 2021 01 02 2021 08 23 Coronavirus infectious disease 2019 (COVID-19) is confirmed to develop neurocognitive complications. In the present paper, we describe two patients with laboratory-confirmed COVID-19 and excessive daytime sleepiness. In the present study, we reported two laboratory-confirmed cases of COVID-19 with excessive daytime sleepiness. Patients had drowsiness and mild confusion on presentation. In both cases, CNS infections, including meningitis and encephalitis, were ruled out. Both patients’ symptoms remarkably improved following the therapeutic course indicating the direct effect of SARS-CoV2 in sleep modulating centers on the brain. COVID-19 should be considered in patients with excessive daytime sleepiness and drowsiness in the current outbreak. https://acta.tums.ac.ir/index.php/acta/article/view/9057