Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 6 2021 08 14 346 350 Fardin Yousefshahi 1 Department of Anesthesiology and Critical Care and Pain Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Hossein Majedi Ardakani Department of Anesthesiology and Critical Care and Pain Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.AND Department of Pain Medicine, Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Mehdi Sanatkar Department of Anesthesiology and Critical Care and Pain Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Reza Atef yekta Department of Anesthesiology and Critical Care and Pain Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Alireza Takzare Department of Anesthesiology and Critical Care and Pain Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Ebrahim Espahbodi Department of Anesthesiology and Critical Care and Pain Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2021 02 04 2021 04 19 Cataract surgery sometimes is associated with adverse effects, such as dryness, burning, and patient discomfort. This study evaluates the treatment of dry eye syndrome and pain caused by corneal damage following cataract surgery with pregabalin compared to placebo. In our double-blind clinical trial, a total of 60 cases were divided into two groups. The pain score was assessed by the Numeric Rating Scale (NRS), and the impact of pain and dryness on the patient's performance was evaluated by the Brief Pain Inventory (BPI). The patient's pain score was evaluated postoperatively and followed for six weeks after the procedure. After the sixth week of the study, NRS, BPI, and photophobia in the pregabalin group were significantly different from the placebo group. Pregabalin can significantly reduce chronic and resistant eye pain after cataract surgery.   https://acta.tums.ac.ir/index.php/acta/article/view/9141