Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 3 2021 03 13 173 176 Shahin Besharati Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Zahra Abbaspourrad Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Hossein Chiti Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Negin Parsamanesh Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran 2021 02 08 2021 02 19 The 2019 global Coronavirus syndrome pandemic (COVID-19) has entered more than two hundred countries around the world, involving <82 million persons and >1,800,000 deaths (until January, 1st 2021). We report on COVID-19 infection in the context of a Cushing's syndrome (CS) from Iran. A 36-year-old man with proximal myopathy, plethora, and striae with central obesity was evaluated for Cushing's syndrome. During the high dose dexamethasone test, the patient developed symptoms of cough, low-grade fever, and weakness then was admitted to the ICU with a diagnosis of COVID-19. Despite treatment according to national protocols for COVID-19, the patient unfortunately died. In this report, we intend to discuss the various aspects of Cushing's syndrome and severe COVID-19 infection. https://acta.tums.ac.ir/index.php/acta/article/view/9151