Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 59 11 2021 11 17 656 661 Sara Mobarak Clinical Research Development Unit, Taleghani Educational Hospital, Abadan University of Medical Sciences, Abadan, Iran.AND Department of Infectious Disease, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran Asma Mohammadi Clinical Research Development Unit, Valiasr Educational Hospital, Abadan University of Medical Sciences, Abadan, Iran Atefeh Zahedi Department of Public Health, Asadabad School of Medical Sciences, Asadabad, Iran Saeed Jelvay Clinical Research Development Unit, Valiasr Educational Hospital, Abadan University of Medical Sciences, Abadan, Iran.AND Department of Health Information Technology, Abadan University of Medical Sciences, Abadan, Iran Fatemeh Maghsoudi Department of Public Health, School of Health, Abadan University of Medical Sciences, Abadan, Iran Mohammad Hosein Assareh Zadegan Dezfuli Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran Ali Reza Balizadeh Karami Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran Esmat Radmanesh Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran. AND Department of Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran 2021 02 19 2021 08 11 SARS-CoV-2 that causes Coronavirus disease 2019 (COVID-19) was first known in Wuhan, China, in December 2019. The aim of this study was to evaluate the level of common hepatic, renal, and cardiac diagnostic markers in hospitals in patients with severe COVID 19. In this study, 259 patients with symptoms of severe COVID-19 and a positive RT-PCR assay of nasopharyngeal samples were enrolled. Inclusion criteria are positive for COVID-19 patients at the diagnosis of an infectious disease physician. Diagnostic markers of liver, kidney, and heart were evaluated by age and gender. In this study, 48.3% of patients severe with COVID-19 were male, and 51.7% were female. The mean of markers such as LDH, Direct Bilirubin, SGOT, SGPT, D-dimer was higher than normal, which was observed in men more than women. The mean of CK-MB also was higher than normal, which was observed in women more than men. The highest mean of markers was seen in the older ages. The mean of BUN was observed in the age range of 55-64 years and above 65 years above normal. But the mean of CPK, creatinine, potassium and alkaline phosphatase were normal. The results of the present study showed an increase in the level of some of the most important diagnostic markers of hepatic, renal, and cardiac in patients with COVID 19. This increase was greater in some markers, including SGOT, SGPT, Direct bilirubin, LDH, D-dimer, in men than in women, and more in older patients. https://acta.tums.ac.ir/index.php/acta/article/view/9175