Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 10 2022 12 18 659 662 Dinesh Kumar Sathanantham Department of Cardiovascular and Thoracic Surgery, Government Medical College Kottayam, Kerala University of Health Sciences, Kerala, India Jayakumar Thanathu Krishnan Nair Department of Cardiovascular and Thoracic Surgery, Government Medical College Kottayam, Kerala University of Health Sciences, Kerala, India Joseph Kathayanat Department of Cardiovascular and Thoracic Surgery, Government Medical College Kottayam, Kerala University of Health Sciences, Kerala, India Silpa Raj Department of Pathology, Government Medical College Kottayam, Kerala University of Health Sciences, Kerala, India 2021 03 02 2022 09 16 Phlebosclerosis is defined as the fibrous degeneration of the venous wall, though in history, it has been defined from endophlebitis to hyalinzation of the intima of the venous wall, the actual pathology is obscure. We present a case series of three different cases from three different decades of life, 5th, 6th, 7th  respectively with varied co-morbities, in which we encountered phlebosclerosis , while harvesting GSV for CABG.: To author’s knowledge, this is the first ever indigenous study on phlebosclerosis of GSV, the study would give a excerpt into the continuum on the natural history of the disease. The literature is reviewed and the case is presented. https://acta.tums.ac.ir/index.php/acta/article/view/9208