Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 61 5 2023 08 23 305 310 Vahid Mohammadi Department of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Mohammad Ali Zakeri Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. AND Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Maryam Zakeri Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Vahid Ehsani Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. AND Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 2021 05 01 2023 01 27 Takotsubo Cardiomyopathy (TC) is transient systolic dysfunction localized with electrocardiographic (ECG) changes, and it mimics acute coronary syndrome (ACS). Studies have shown that 95% of the patients have changes in ECG. ECG changes in TC syndrome may be similar to MI. ECG changes can be seen in the form of ST-segment elevation or deep T-wave inversion. TC can be considered a special form of ACS. TC is not a benign entity and conduction abnormalities can occur. The acute phase can be predicted based on decreased EF and the incidence of arrhythmia. A different treatment is used in the acute phase of TC, depending on the hemodynamic condition. Our case illustrates the importance of symptoms such as stress and emotions, age and female gender, clinical manifestations, ECG characteristics, and echocardiography. This paper describes a case of TC from a hospital affiliated to Rafsanjan University of Medical Sciences. The case was a 75-year-old woman with no history of cardiovascular diseases, who has been admitted to the hospital with myocardial infarction. https://acta.tums.ac.ir/index.php/acta/article/view/9364 https://acta.tums.ac.ir/index.php/acta/article/download/9364/5788