Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 2 2022 02 23 132 134 Navid Kalani Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran Mohammad Reza Zare Poostchi Ophtalmogy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Sara Safniyat Poostchi Ophtalmogy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Naser Hatami Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran. Seyed Ahmad Razavizadegan Department of Ophthalmology, Jahrom University of Medical Sciences, Jahrom, Iran 2021 05 16 2021 12 13 Ever since the new coronavirus has become the cause of the COVID-19 pandemic, it has manifested with unknown and new presentations. In this report, we are presenting a 46-year-old female infected with COVID-19 (confirmed by RT-PCR nasal swab test) and a known case of Diabetes mellites type 2 who had a history of ICU admission due to COVID-19 with uncontrolled diabetes mellites. In the second admission after recovery, she had blurred vision. Fundus examination revealed multiple yellow-white well-demarcated nonpigmented masses. Diagnosis of the multiple subretinal abscesses was confirmed. KOH-Calcofluor staining of vitreous fluid was negative for fungal infections of the eye. No polymorphonuclear leukocytes (PMN), epithelial cells nor any organisms were detected. The patient was treated with an injection of the intravitreal Amphotericin B 10 µg/0.1cc.  To our knowledge, the presented case is the first case of the subretinal abscess after covid-19 infection. https://acta.tums.ac.ir/index.php/acta/article/view/9395