Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 6 2022 07 11 338 344 EN Mohammad Bargahi Department of Emergency Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Nafiseh Rastgoo Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. Farzane Aryanejad Department of Emergency Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Sohrab Esmaielzade Department of Emergency Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. Roomina Nemati School of Medicine, University of Texas at Arlington, Arlington, Texas, USA. Mehdi Ghaebi Department of Emergency Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. Arezoo Bajelan Department of Emergency Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. Soheil Soltani Department of Emergency Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran 2021 08 12 2021 12 28 Dyspnea and decreased O2 saturation are the most common causes of hospitalization in noncritical COVID-19 patients. Breathing exercises and chest physiotherapy are used for managing the patients. These treatments are, however, not well supported by scientific evidence. In a randomized controlled trial, 80 patients were randomly assigned to planned breathing exercises (n=40) and control groups (n=40). The participants in the intervention group were instructed to blow into a balloon five times a day while lying down. Other therapies were similar in both groups. The severity of dyspnea at rest/after activity and peripheral oxygen saturation (SpO2) with/without O2 therapy were compared between the two groups on the first, second, and third days. The study findings showed no statistically significant difference in SpO2 with/without O2 therapy on the first, second, and third days between the two groups. Although the severity of dyspnea showed no significant difference between the two groups, the mean score of dyspnea at rest (2.72±2.25 vs. 1.6±1.21, P=0.007) and after activity (4.53±2.04 vs. 3.52±1.66, P=0.017) improved in the intervention group on the third day. Balloon-blowing exercise improves dyspnea in noncritical Covid-19 patients, but it does not significantly improve oxygenation. https://acta.tums.ac.ir/index.php/acta/article/view/9591