Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 6 2022 07 11 329 337 EN Vahideh Lalehfar Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Farnoosh Larti Department of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Ali Mehrakizadeh Department of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Alireza Bakhshandeh Department of cardiovascular surgeryl, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Roya Sattarzadeh Badkoubeh Department of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Shabnam Mohammadzadeh Department of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Akram Sardari Department of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran 2021 12 28 2022 05 10 Solid-organ transplantation recipients were assumed highly vulnerable to coronavirus disease 2019 (COVID-19). However, the results of previous studies in patients with orthotopic heart transplantation (OHT) under immunosuppressive therapy are contradictory. Therefore, we aimed to assess the prevalence of COVID-19 infection and associated risk factors, along with the six-month outcomes in COVID-19 positive OHT patients. This single-center telephone-based survey was conducted on OHT patients. Using a detailed questionnaire, exposure to COVID-19, related symptoms, and preventive self-care measures were collected. Outcomes of COVID-19-positive patients were reassessed using another survey six months later. 118 OHT patients (male: n=87, 73.7%) were included with a mean age of 45.3±13.1 years. Sixteen patients (13.5%) reported one or more symptoms compatible with COVID-19, of whom 12 (10.2%) tested positive. Our results indicated no statistically significant association between COVID-19 and comorbidities. Poor adherence to self-care measures and contact with positive index cases were both significantly associated with COVID-19 infection (P<0.001). A later six months follow-up showed that two out of 12 (16.6%) COVID-19 positive OHT patients died. There was no statistically significant difference between the prevalence of COVID-19 in our patients compared to Iran’s general population (P=0.152). Non-compliance with personal protective protocols and a history of contact with COVID-19 cases were the most risk factors for COVID-19 infection in OHT patients. https://acta.tums.ac.ir/index.php/acta/article/view/9883