Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 124 126 Mohammadi M 2015 09 28 Botulinum toxin A (BTA) inhibits presynaptic release of acetylcholine at the neuromuscular junction and has reportedly been successful in the treatment of spastic disorders.To evaluate the effect of botulinum toxin on cerebral palsied children with spastic or mixed type of the disease, especially those patiens having spasticity as a cardinal symptom without joint contracture, we designed the following study. Ninety-one cases (55 of referred patients to pediatic Neurology outpatient clinics of children’s Medical Center) were given BTA injections in affected muscles of the lower limb. They were reevaluating 3 to 5 weeks and 3 months later for type of walking and range of affected joints’ movement. The study showed a clinically significant gait improvement in 71.2% of patients (P https://acta.tums.ac.ir/index.php/acta/article/view/2297 https://acta.tums.ac.ir/index.php/acta/article/download/2297/2287

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 127 131 Zarban A Doosti M Esteghamati A Allameh A 2015 09 28 Enhanced oxidative stress in diabetes mellitus may contribute to the pathogenesis of diaetic complications. In this article, the stress oxidative generation has been studied in experimental diabetes by ferric reducing ability of plasma assay, a sensitive and simple method, and by other oxidative damage markers. The ferric reducing ability of plasma values as a total antioxidant capacity were significantly decreased at the 3th 4th weeks of stuy ( P https://acta.tums.ac.ir/index.php/acta/article/view/2298 https://acta.tums.ac.ir/index.php/acta/article/download/2298/2288

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 132 137 Zaini F Sadeghi G Elmi Akhouni E 2015 09 28 The values of fourteen carbohydrates assimilation patterns were investigated for typical and atypical strains of Microsporum canis. Thiry eight strains of typical and twenty two strains of atypical Microsporum canis, Microsporum canis NCPF 352 and one Microsporum distortum were included in this study. Statistical analysis of the results indicated that despite limited variations within the pattern of carbohydrate utilization, no correlation. The results also revealed that erythritol and trehalose were best utilized for sporulation by the typical and atypical strains of Microsporum canis. Production of obundant macroconidia, microconidia and chlamydoconidia by use of erythritol and trehalose suggested that these two carbohydrates were effective in production of fluffly appearance in colonies examined. The Microsporum canis NCPF 352 strongly utilized glucose, mannitol and melibiose in addition to the two above-mentioned carbohydrates. Weak erythritol assimilation was observed by Microsporum distortum.Carbohydrate utilization pattern is unable to differentiate typical and atypical strains of Microsporum canis. But it could be regarded as a valuable aid for identification of Microsporum distortum as well as marker in epidemiological investigations. https://acta.tums.ac.ir/index.php/acta/article/view/2299 https://acta.tums.ac.ir/index.php/acta/article/download/2299/2289

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 138 147 Shakibaei M 2015 09 28 When grown in monolayer culture at low density and with the addition of serum, cartilage cells dedifferentiate or are overgrown by fibroblast-like cells. The aim of this study was to optimize the cultivation of chondrocytes in monolayer culture and to slow down their transformation or their overgrowth by fibroblast-like cells. The interaction between chondrocytes and cartilage-specifc matrix is mediated largely by the β1 subfamily of integrin receptors. This interaction can be regulated or synergized by growth factors, such as IGF-I, which stimulates many chondrocyte functions.For this reason isolated chondrocytes of cartilage anlagen from 17- day old mouse embryos were grown on collagen type II-coated substrates with or without the addition of IGF-I (Insulin like Growth Factor-I) Using this model chondrocytes grown on collagen type II with or without IGF-I maintained their round phenotype until the end of cultivation. The neutral red assay revealed that chondrocytes cultivated on collagen type II in the presence of exogenous IGF-I, showed a significantly higher density of chondrocye adhesion from the beginnig of cultivation onwards in comparison to chondrocytes cultivated on collagen type II without IGF-I treatment. The cartilage-specific surface receptors (integrins of the β1- group) could also be demonstrated on the membrane of these cells. Chondrocytes cultivated on plastic with or without treatment with IGF-I, resulted in mixed cultures consisting of fibroblast-like cells and round chondrocytes as observed from the beginning of cultivation onwards. After a 3 to 5 culture period, flat fibroblast-like cells predominated.Hence, collagen type II and IGF-I prevent chondrocyte dedifferentiation to fibroblastike cells and this model allows a pure chondrocyte culture. https://acta.tums.ac.ir/index.php/acta/article/view/2300 https://acta.tums.ac.ir/index.php/acta/article/download/2300/2290

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 148 151 "Shakarami M Tabari M " 2015 09 28 A middle-aged woman with the chief complaints of dysnea and chest pain was referred to our center. Chest X-rays and computed tomoram revealed a mass in the posteriof mediastinum, which was excised in toto. Pathologicat report of the specimen labeled it as normal thyroid tissue (aberrant thyroid). https://acta.tums.ac.ir/index.php/acta/article/view/2301 https://acta.tums.ac.ir/index.php/acta/article/download/2301/2291

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 152 155 "Moradman S Hatamizadeh P " 2015 09 28 Exploration of the interlead QT variation (QT dispersion) introduced cardiologists to some new concepts including the deed to define a standard for lead selection in the measurement of QT interval and the reason or factors contributing to QT dispersion. Hoseever, still there dose not exist a generally acceptable standard for lead selection and the reason for the QT dispersion has not been given the importance it deserves. Only a few hypotheses have been suggested, none of which have been seriously experimented. Finding important factors cuusing QT dispersion can lead to a better understanding of its basics and more accurate usage of QT dispersion as and index in clinical practice. This paper examines the "Vector Cancellation Theory" on the basis that if "vector cancellation" affects the QT interval duration in different leads, the ncurest had to rhe mean QR.S axis must have the longest QT interval and vice versa. This was tested on the electrocardiograms taken from 34 people without cardiovascular problems. We came across a statistically significant inverse correlation between the QT interval in each limb lead and its angle to the ECG's mean QRS axis. Thus this study gives weight to the vector cancellation theory. And as the nearest lead to the Mean QRS Axis is likely to have the longest QT interval and given its practicality. It can be suggested as the standard lead for measuring QT internal in an electrocardiogram. https://acta.tums.ac.ir/index.php/acta/article/view/2302 https://acta.tums.ac.ir/index.php/acta/article/download/2302/2292

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 156 159 "Abdollahi M Entezari M Akhgari M " 2015 09 28 The effects of zinc and mercury on human erythrocyte acetylcholinestrase activity were studied. Blood used in this study was obtained from 24 apparently healthy individuals and after hemolysation, was treted with 3 diferent concentrations of zinc and mercury. Significant suppressions in acetylcholinestrase activity were recorded in treated samples by zinc and mercury. When compared to controls the remaining activity was found to be 53% with the highest concen.tration of zinc (2.1 mg/dl, p https://acta.tums.ac.ir/index.php/acta/article/view/2303 https://acta.tums.ac.ir/index.php/acta/article/download/2303/2293

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 160 165 "Ghalibafian M Haddad P dehshiri K " 2015 09 28 Breast conservation surgery combined with radiation therapy is now an accepted option for the treatment of early breast cancer. So we decided to evaluate the results of such treatment in our first group of patients treated by this method. From 1992 to 1996 , one hundred patients with Stage I and II breast cancer treated with breast conservative surgery (lumpectomy or quadrantectomy). Were irradated at Tehran Cancer Institue and Marie Curie Clinic. In stage II the whole breast and the draining lymph-node areas, and in stage I only the breast were irradiated to 50 Gray (Gy) in 5 weeks using cobat 60. a bososter dose of 10 Gy was given at the primary tumor site by photons in 1 weeks. Thirty- eight percent of patients received adjuvant chemotherapy. Tomoxifen was given to 96% . with a mean and median follow-up time of more than 3 years, three local recurrences and eight distant metastases occurred. The estimated 5 –year recurrence-free survival rate was 92% and the metastasis-free survival rate was 81%. Seventy-seven percent were disease-free with preserved breast. Young patient and those with positive margins had a higher risk for local failure. Nodal metastasis and the omission of adjuvant tamoxifen increased the distant failure rate. Complications were rare, excep for mild telangiectasia in four patients. The cosmetic result was exccllent or good in 90% of patients and the only factor with a statistically significant effect on cosmetic result was the treatment of both tangential fields per day. https://acta.tums.ac.ir/index.php/acta/article/view/2304 https://acta.tums.ac.ir/index.php/acta/article/download/2304/2294

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 166 167 "Moatamedi M Banki A Sahraian M " 2015 09 28 The term reflex epilepsy in reserved for a small subgroup o seizures that occur regularly in response to specific stimuli. Our patient is a 20- year old male, who had pleasure, euphoria, loss of conciousness and generalized tonic- clonic convulstion when he watched TV since ten years. During puberty the patient that self-induced reflex epilepsy with photic stimulation, when watching TV or looking at sun and with had moving in front of his eyes to produce flickers. The patient first had sex pleasure, euphoria, erection and ejaculation, and then developed loss of consiousness and generalized tonic- clonic seizure, that took about 4-5 min. what is more intersing is that he asked us for a kind of drug that controlled his generalized tonic-clonic seizures but not his pleasure and orgasm, and he said that he would refuse any drug interfered with his orgasm. https://acta.tums.ac.ir/index.php/acta/article/view/2305 https://acta.tums.ac.ir/index.php/acta/article/download/2305/2295

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 168 173 Kariminia A Keyhani A Asslanian S Alimohammadian MH 2015 09 28 Stage-specifci developmental forms of Lesihmania major promastigotes were grown in vitro. Procyclic and metacyclic promastigotes were cultured and separated by peanut agglutinin. The axenic amastigote form were prepared by culturing the promastigotes in acidic medium at 35C.These three forms of parasites were used as antigens to study cytokine production in whole blood culture of healthy individuals (no= 13) and early IFN-γ and LI-10 production were determined by specific sandwich ELISA. The results showed that logarithmic promastigotes were more potent to induce IFN-γ production than metacyclic and axenic amastlgotes parasites. In contrast, LI-10 production was significantly higher in supernatants of cells stimulated by the two infective forms. In addition, the adjuvant effect of BCG on cytokine production induced by these three types of promastigotes was studied. BCG showed augmenting effect on cytokine production, however three were still differences between logarithmic and the two other forms since logarithmic parasites still induced higher amount of IFN-γ and lower amount of LI-10 These results demonstrated that logarithmic promastigotes of L. major are more potent to induce T helper 1 response which might have implication in vaccine preparation. https://acta.tums.ac.ir/index.php/acta/article/view/2306 https://acta.tums.ac.ir/index.php/acta/article/download/2306/2296

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 38 3 2000 09 15 289 292 EN Asadolah Alidoosti Department of Radiation Oncology, Imam Hossein Hospital, Shaheed Beheshti Univesity of Medical Sciences, Tehran, Iran. Farnaz Taslimi Department of Radiation Oncology, Imam Hossein Hospital, Shaheed Beheshti Univesity of Medical Sciences, Tehran, Iran. Ahmad Ameri Department of Radiation Oncology, Imam Hossein Hospital, Shaheed Beheshti Univesity of Medical Sciences, Tehran, Iran. Majir Sheibani Khosro Department of Radiation Oncology, Imam Hossein Hospital, Shaheed Beheshti Univesity of Medical Sciences, Tehran, Iran. Reza Miri Department of Radiation Oncology, Imam Hossein Hospital, Shaheed Beheshti Univesity of Medical Sciences, Tehran, Iran. Parvin Yavari Department of Radiation Oncology, Imam Hossein Hospital, Shaheed Beheshti Univesity of Medical Sciences, Tehran, Iran. 2015 09 28 Cancer patient receive various cytotoxic drugs in association with antiemetic drugs such as 5HT3 receptor antagonists as their chemotherapy regimen. 5HT3 receptor antagonists have been reported to produce changes in ECG parameter. There are only a few studies about cardiovascular events of these drugs in patient receiving potentially cardiotoxic chemotherapies. The subject of this study is to evaluate ECG changes after administration of chemotherapeutic agents and granisetron (the most commonly used 5HT3 antagonist in Iran) in adults with cancer. For this clinical trial study, all cancer patients referred to department of radiation oncology of Imam Hossein Hospital since August 2005 to March 2006 were evaluated if they had inclusion criteria. Granisetron (3 mg) was infused intravenously over 30 seconds just a few minutes before chemotherapeutic agent administration. The 12-lead ECG recording was obtained before and 90 minutes after infusion of granisetron. One cardiologist determined PR, QRS, QTc intervals and heart rate of all ECGs. During the study period 54 patients fulfilled our criteria. With paired t-test, the PR and QTc intervals, but not QRS interval showed statistically significant prolongation after drug infusion (P < 0.0001), and heart rate showed statistically significant decrease (P < 0.0001). The ECG findings of chemotherapeutic agents and granisetron administration were prolongation of PR and QTc intervals and decrease of heart rate (P < 0.0001). Although these changes did not cause clinical signs, with keeping in mind that there may be possible drug-drug interactions and preexisting cardiac comorbidities in cancer patient, it seems reasonable and necessary to consider physical condition specifically cardiac condition and drug usage of each patient, while designing chemotherapy regimen and supportive drugs. https://acta.tums.ac.ir/index.php/acta/article/view/3593 https://acta.tums.ac.ir/index.php/acta/article/download/3593/3569

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 47 4 2009 08 15 293 296 EN Fatemeh Mirzaie Department of Obstetric and Gynecology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. Fatemeh Rahimi-Shorbaf Department of Fetal Maternal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Amir Hossian Kazeronie Department of General Practitioner, School of Medicine, KermanUniversity of Medical Sciences, Kerman, Iran 2015 09 28 The aim of this study was to investigate C-reactive protein (CRP) level in preeclampsia (PE) and its association with the severity of the disease. This cross-sectional study included 43 women with mild PE, 43 women with severe PE, and 43 healthy pregnant. They were selected in the third trimester of pregnancy in the Afzalipour Hospital, Kerman, Iran, from March 2006 to March 2007. Mean diastolic pressure and l