Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 1 5 "Ghavamzadeh A Alimoghadam K Bahar B Foroughi F Jahani M " 2015 09 28 Allogeneic bone marrow transplantation is the only definie cure in thalassemia and its most important complication is chronic graft-versus-host disease (cGVHD). We analysed the incidence of cGVHD and its associated risk factors in a group of 89 Iranian thalassemic patients of HLA-identical sibling transplants surviving at least 90 days after transplantation.In the majority of cases (39) cGVHD occurred in the first year following transplant (median 271 days). Actuarial probability of cGVHD in 1 year was 43.8±10% (95% CI). In univariate analysis, the most important risk factor was the type of transplant: 78.9% (15.19) of patients who underwent peripheral blood stem cell transplant developed cGVHD compared with only 34.3% (24/70) of those who underwent bone marrow transplant (RR=3.65 p BM p https://acta.tums.ac.ir/index.php/acta/article/view/2538 https://acta.tums.ac.ir/index.php/acta/article/download/2538/2525

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 6 10 Mansoori SD Shahgasempour S 2015 09 28 The immune responses that develop following Epstien-Barr Virus (EBV) infection are complex and involve both humoral and to a greater extent cell-mediated immune mechanisms. To evaluate the immune response, flow cytometric analysis of the peripheral blood of six patients during the acute phase of EBV infection was performed. This analysis revealed a significant increase in the percentages and the absolute number of CD8+cytotoxic and activated (HLA-DR+ - T lymphocytes and in some cases with a concomitan decrease in the percentages of B (CD19+) lymphocytes and T helper (CD4+) lymphocytes. These patient invariably had inverted CD4/CD8 ratio. All changes reversed to normal level during the recovery phase of infection. It is therefore concluded that EBV specific cytotoxic and activated T lymphocytes are essential in controlling acute EBV infection presented by the infected B cells. https://acta.tums.ac.ir/index.php/acta/article/view/2539 https://acta.tums.ac.ir/index.php/acta/article/download/2539/2526

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 11 15 Naraghi M Madani SZ Kashfi A 2015 09 28 A 35-year-old man was admitted because of a 2-year history of nasal obstrction, a nasopharyngeal mass, malaise, and massive cervical lymphadenopathy. Nasal symptoms and nasopharygeal mass were due to rhinoscleroma that was confirmed by an incisional biopsy and culture. The patient underwent cervical lymph node biopsy and culture. The patient underwent cervical lymph node biopsy that revealed the tissue compatible with Rosai-Dorfman disease, also called sinus histiocytosis with massive lymphadenopathy. Rhinoscleroma was treated by a combination of excision and antibiotics. Culture became negative for Klebsiella rhinoscleromatis. Then prednisolone administered for one month and gradually tapered. Lymph nodes became small at the end of treatment. Twelve months follow-up showed no evidence of recurrence of both diseases. To the best of our knowledge, this is the first report of association of rhinoscleroma with Rosai-Dorfman disease. Association of these two rare diseases may be due to just a coincidence, or a common immunologic or microbiologic underlying factor https://acta.tums.ac.ir/index.php/acta/article/view/2540 https://acta.tums.ac.ir/index.php/acta/article/download/2540/2527

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 16 19 Mamishi S Mojtahedi SY Mahjoub F 2015 09 28 Idiopathic lobular panniculitis, sometimes called relapsing febrile nodular panniculitis or weber Christian disease first desribed in 1892 by pfeifer, is the term used to describe an group of disease that present as subcutaneous inflammatory nodules and histologically display an inflammatory focus primarily within the fat lobules. Weber-christian disease is the term applied to idiopatic cases of lobular panniculitis associated with systemic symptoms.the disease occurs predominantly in middle aged females although it can be seen in both sexes and at all ages. Hereby, we represent a case of diagnosed weber-christian disease in a 9-month-old boy. The diagnosis was approved by skin biopsy and exclusion of other differential diagnosis of lobular panniculitis. Weber-christian disease is a rare disease especially in children and can be misdiagnosed, so we found it interesting to report this case. https://acta.tums.ac.ir/index.php/acta/article/view/2541 https://acta.tums.ac.ir/index.php/acta/article/download/2541/2528

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 20 25 "Kotcharian A Aeen Mohammadi A Mojtahedzadeh R " 2015 09 28 There is now clear evidence that the atherosclerotic process begins in childhood. A major and important cause of atherosclerosis and coronary heart disease (CHD) is elevated cholesterol level. In order to clarify the sigificance of elevated Total Cholesterol (TC) in children who live in Tehran, we measured the lipid profiles including TC Triglyceride (TG), and High density Lipoproteein Cholesterol (HD –C) of 1000 twelve- year-old children. Low-density lipoprotein Cholesterol (LDL-C) value was calculated by using friedwald formula. The mean level of TC in all cases reached 170±39 mg/dl. The mean level of LDL-C, HDL-C and TG were 101±38 mg/dl, 48±12mg/dl, and 105±52 mg/dl, respectively. Tc level in 16.4% of the cases was above 200 mg/dl and 16% had LDL-C levels more than 130mg/dl. Mean LDL-C level in the boys was 6.2 mg/dl (with 95% confidence interval of 1.3 to 11.1) more than girls. Also mean HDL-C level in the girls was 4.1 mg/dl (with 95% confidence interval of 2.5 to 5.7) more than that of boys (P-value in both=0.000). TC and HDL-C levels in the northern parts of Tehran were significantly higher than the southern parts. Mean LDL-C and TG levels didn’t show any differences. Regarding the normal range of TC ( https://acta.tums.ac.ir/index.php/acta/article/view/2542 https://acta.tums.ac.ir/index.php/acta/article/download/2542/2529

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 20 25 Arab M Mansoori D Abbasidezfouli A Shadmehr M Afsari M 2015 09 28 Splenic Tuberculosis is a rare entity, particularly among immunocompetent hosts. Hererin, we present a 23 year-old man who was reffered with fever of unknown origin and eventually diagnosed to have splenic tuberculosis with an involvement of a single axillary lymph node as the sole site disease in the other organs.Despite two months of treatment with antituberculous agents due to necrotising granulomatous lesion of axillary lymphadenitis, the patient underwent splenectomy for complete recovery. It seems that in this rare from of tuberculosis, splenectomy in addition to standard antituberculosis treatment is curative https://acta.tums.ac.ir/index.php/acta/article/view/2543 https://acta.tums.ac.ir/index.php/acta/article/download/2543/2530

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 29 32 Kavehmanesh Z Kosari F 2015 09 28 This report presents an 11 year-old girl with benign recurrent cholestasis (BRIC) who developed episodes of severe jaundice and pruritus at the ages of 2.5 and 10 years. Each episode lasted for 3-4 months. The peak level of serum bilirubin reached 33-37 mg/dl.Liver function tests were all normal during the attack except for increased alkaline phosphatase and prolonged prothrombin time responsive to vitamin K injection. All laboratory tests were normal between attacks. Other causes of liver diseases and cholestatic disorders were excluded. Imaging studies performed during the second attack all were normal.So, diagnosis of BRIC should be kept in mind in pediatric patients with cholestasis. https://acta.tums.ac.ir/index.php/acta/article/view/2544 https://acta.tums.ac.ir/index.php/acta/article/download/2544/2531

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 33 37 Fahimi F Siavoshi F Ala S 2015 09 28 Animal models for H.pylori infection have been developed to clarify the pathogenesis, testing new therapies and developing vaccines against human H.pylori infection. Although rats have been used extensively for gastric ulceration and acid secretion studies, the animal is not normally infected with H.pylori.Several chemicals such as ethanol and ammonium hydroxide can induce gastric erosion and interact with gastric mucosal defense mechanisms. The aim of the present study was to investigate the effects of pretreatment with the gastroinvasive agents on colonization of H. pylori with the gastroinvasive agents on colonization of H. pylori in not germ-free rats in order to overcome the resistance against H. pylori in rats. After 24 h fasting, the rats were divided into three major groups. Animals in the first group were not pretreated with any chemicals. The two other groups were pretreated with ethanol (60%) or ammonium hydroxide (1%) before inoculation of 1 mL H. pylori suspension (3×108 cfu/ml). The results showed that H. pylori could not colonize in rats, even with ethanol or ammonium hydroxide pretreatment. An understanding of the mechanism of this resistance can help researchers to develop new therapeutic or preventive drugs against H. pylori and it is recommended to perform more investigation to clarify the reason of this resistance https://acta.tums.ac.ir/index.php/acta/article/view/2545 https://acta.tums.ac.ir/index.php/acta/article/download/2545/2532

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 38 45 "Takavar A Rad Goodarzi M " 2015 09 28 Fue to the importance of selecting imaging parameters in magnetic resonance brain angiography, this study was carried out to choose optimum theoretical and experimental parameters for improving image controast and resolution and achieve shorter imaging time for practical reasons.A 1.5T super conductive magnet MRI with gradient power of 13 nT/m and Larmour frequency of 63 MHz with imaging coli of 30 cm was used.In this study, 5 healthy volunteers and 34 patients were the subjects of brain angiography. Flip angles of 15-20 degrees for peripheral brain vessels and 35-45 degrees for internal brain vessels were found to give higher contrast and better image resolution with a artifact. Using our optimum imaging parameters, (ie [TR/Te/FA/FOV] [40ms/7cm/20°/1mm 023cm], besides obtaining high quality angiography images, routine imaging time of 9-12 minutes was reduced to 7.3 mintues https://acta.tums.ac.ir/index.php/acta/article/view/2546 https://acta.tums.ac.ir/index.php/acta/article/download/2546/2533

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 46 48 "Pourang H Sadighi A " 2015 09 28 Hirchsprung’s disease is a developmental disorder of the enteric nervous system, characterized by abdsence of ganglion cell in the myenterric and submucosal plexuese along a variable portion of the distal intestine.The purpose of this study is the presentation of a new procedure for reduction of the postoperative complications of Hirschsprung’s disease (HD) by offering a modified Swenson’s technique. This was a chieved through a 10 years study of 157 patients with HD, of whom 74% were male and 26% wre female. In 100 cases the disease was diagnosed in the early neonatal period, in 129 cases the involved segments were rectosigmoid or shortsegment. Our choice of operation was a new modification of swenson’s type of pull through (Swenson’s operation + posterior rectal wall myectomy). Phatholgical examination has confirmed the diagnosis of HD in all patients. The overall results of surgery were good in 81% and there was no mortality. https://acta.tums.ac.ir/index.php/acta/article/view/2547 https://acta.tums.ac.ir/index.php/acta/article/download/2547/2534

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 1 2002 03 15 49 51 "Mahbod G https://acta.tums.ac.ir/index.php/acta/article/view/3538 https://acta.tums.ac.ir/index.php/acta/article/download/3538/3514

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 47 1 2009 02 15 31 34 EN Mohammad Mehdi Karambin Department of Pediatrics, School of Medicine, Guilan University of Medical Sciences, Guilan, Iran. Hooman Hashemian Department of Pediatrics, School of Medicine, Guilan University of Medical Sciences, Guilan, Iran. 2015 09 28 To determine the rate of different types of arthritis in children. We prepared a retrospective descriptive study and included the whole 100 cases of arthritis referred to 17-Shahrivar Hospital, Rasht, Guilan during a 3 years period. Using their medical files, data including age, sex, season of admission, history of trauma, signs and symptoms, lab findings and duration of hospitalization were collected. SPSS 13.0 (statistical software) applied for statistical analysis. The most common age of involvement ranged 6-9 years. Septic arthritis, brucellosis, and rheumatoid fever were the most frequent causes of arthritis in our study. Fever and restricted range of motion had the highest rate among different signs and symptoms. Lab data demonstrated leukocytosis, positive CRP, and increased ESR among 74, 79.5, and 73 percent of our patients, respectively. According to the high prevalence of septic arthritis and the arthritis due to brucellosis and rheumatoid fever, it seems that mentioned diseases are still major problems in the issue of hygiene management. https://acta.tums.ac.ir/index.php/acta/article/view/3539 https://acta.tums.ac.ir/index.php/acta/article/download/3539/3515

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 47 1 2009 02 15 35 40 EN Hasan Hosain Zadegan Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran. AND Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Bahram Delfan Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. AND Department of Pharmacology, School of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran. 2015 09 28 Biofilm is a community of bacteria which are attaching to a surface. They are responsible for many of catheter related or dental plaque related infectious diseases. Different approaches have been used for preventing biofilm related infections in health care settings. Many of these methods have disadvantages such as chemical based complications, and emergent antibiotic resistant strains. Therefore antibiofilm effect of Dentol was evaluated on two important medical bacterial biofilms in this study. Methods: Minimum inhibitory concentrations (MIC) of Dentol was calculated by serial dilution method by microtiter plates against standard bacteria. Antibiofilm effect of Dentol was evaluated by microtiter plate assay and after measuring absorbance in 550 nm, the difference between groups was calculated by Cruskal-wallis and Mann-withney tests. Results: 1:80 (12.5 μl/ml) & 1:20 (50 μl/ml) dilutions of commercially available Dentol were measured as MICs for S.aureus and P.aeruginosa, respectively. Two-fold dilutions of Dentol MICs completely eradicated and inhibited biofilm formation. Statistical analysis between test groups revealed significant differences. Disscussion: Dentol is a medicinal herbal essential oil derived from Satureja khuzestanica (SKEO). Several in vitro studies have reported its antidiabetic, analgesic, anti-inflammatory, and anti-hyperlipidemic effects. So because of complications that have been encountered in health care settings from routine methods of catheter processing, and biofilm related problems, efficacy of Dentol for destruction of bacterial biofilms as a safe material was studied. https://acta.tums.ac.ir/index.php/acta/article/view/3540 https://acta.tums.ac.ir/index.php/acta/article/download/3540/3516

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 47 1 2009 02 15 41 45 EN Ebrahim Ameri Department of Orthopedic and Spine Surgery, Shafayahyaiian Hospital, Iran University of Medical Sciences, Tehran, Iran. Hamid Behtash Department of Orthopedic and Spine Surgery, Shafayahyaiian Hospital, Iran University of Medical Sciences, Tehran, Iran. Bahram Mobini Department of Orthopedic and Spine Surgery, Shafayahyaiian Hospital, Iran University of Medical Sciences, Tehran, Iran. Farzad Omidi-Kashani Department of orthopedic Surgery, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Marzieh Nojomi Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. 2015 09 28 Surgery on the skeleton frequently requires harvesting of autogenous bone graft from the pelvis, but this procedure is complicated by problems. The purpose