Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 73 78 Tamiolakis D Venizelos J Kotini A Skafida P Cheva A Papadopoulos N 2015 09 28 Less than 5% of prenatal thymoctes express HLA-DR before week 12 of gestation. However, the number of HLA-DR- positive cells increases during the late second and third trimesters of development. To determine the role of alpha-smooth muscle actin in fetal thymic HLA-DR signaling in different stages of development we examined and compared the immunohistochemical expression of alpha-smooth muscle actin in the myoid cells of the thymic medulla stroma in the 2 nd, and 3rd trimesters of gestation respectively, over the equivalent expression of the protein in the 1 st trimester, in relation with the appearance of HLA-DR-positive thymocytes. Our results demonstrated a quantitative difference in the second and third trimesters of development concerning the expression of alpha-smooth muscle actin in the stromal myoid cells of the thymic medulla over the equivalent expression of the protein in the first (P https://acta.tums.ac.ir/index.php/acta/article/view/2638 https://acta.tums.ac.ir/index.php/acta/article/download/2638/2620

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 79 83 Mirhendi SH Kordbacheh P Pezeshki M Khorramizadeh MR 2015 09 28 Opportunistic fungal infections including candidiasis have increased dramatically in recent years. Most medically important fungi are Candida species. Rapid identification od Candida isolates to the species level in the clinical laboratory is necessary for more rapid and effective antifungal therapy and to facilitate hospital infection control measures. Conventional morphological methods for identification of candida species are often difficult and time consuming. Molecular DNA-based techniques provide useful alternative methods. In this study using universal primers, ITS1-ITS4 region of the fungal rRNA genes were amplified. Digestion by the restriction enzyme Mspl allowed us to identify of C. albicans, C. glabrata, C. krusei, C. tropicali, and C. guilliermondii. C. guilliermondii produces 3 bands whereas the others gave two distinctive bands after digestion. This panel of PCR-restriction enzyme could be rapid, simple and useful in diagnostic studies of candida and candidiasis. https://acta.tums.ac.ir/index.php/acta/article/view/2639 https://acta.tums.ac.ir/index.php/acta/article/download/2639/2621

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 84 90 "Pipelzadeh MH Dezfulian A Koochek MH Moradi M " 2015 09 28 The aim of this study was to compare the effectiveness of Fenugreek (Trigonella foenum-graecum) with that of lovastatin in restoration of endothelia function in the aorta taken form aged N-Mair rats. For this purpose, 4 groups of old N-Mari rats were used (n=6), normal saline treated control group, lovastatin (10 mg/kg, orally) and fengreek seed powder in normal saline suspension (100 or 500 mg/kg) were administered orally daily for 8 weeks. The rate of relaxation of ephedrine- precontracted aorta to acetycholine, the lipid profiles, and histological examinations of the aorta were compared between these two groups and with a control non-treated normal saline treated group. The results showed that treatment with lovastatin and fenugreek produced significant reduction in IDL, VLDL triglyceride and total cholesterol, while HDL was increased as compared to control non-treated group. Lovastatin induced an increase in contraction/mg tissue weight. However, improvement in endothelial function was significantly increased in all treatment groups. The histological findings showed significant reduction in thickness and lipid deposits in the aorta in all treatment groups. The improvement in the epithelial function was correlated with LDL-cholesterol lowering and partly with the reduction in the thickness of the aortic intimal layer. This study demonstrated that fenugreek is as effective as lovastatin in reducing the features associated with atherosclerosis. https://acta.tums.ac.ir/index.php/acta/article/view/2640 https://acta.tums.ac.ir/index.php/acta/article/download/2640/2622

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 91 93 Modares Gilani M Paykari N 2015 09 28 To evaluate the maternal serum dehydroepiandrosterone sulfate level as a factor associated with the outcome of labor induction. Venous blood was collected from 45 women at the initiation of labor induction. Pregnancies complicated by maternal corticosteriod use, anterpartum chorioamnionitis, or cesarean delivery for indications other than arrest disorders, were excluded from analysis. In 42 women meeting inclusion criteria, induction followed established protocol. Serum dehydroepiandrosterone sulfate levels were measured by radioimmunoassay and correlated with the outcome of each induction attempt. A successful result was defined as progression to active labor. The welch approximate t-test, Mann-Whitney test, Fisher exact test, simple regression, and multiple regression were used for statistical analysis, with P https://acta.tums.ac.ir/index.php/acta/article/view/2641 https://acta.tums.ac.ir/index.php/acta/article/download/2641/2623

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 94 99 Moradmand S Moosavi M Nematipour E Eslami M Gharouni M Balali R Abdolmotallebi F 2015 09 28 Ramadan fasting is one of the most important religious duties of Muslims, that its effect on the heart has not been determined yet. Our objective was to evaluate the effect of Ramadan fasting on ventricular repolarization as assessed by QT interval, corrected QT interval, QT dispersion or corrected QT dispersion. Sixthy healthy subjects aged 20 to 35 years were dispersion included in this study. QT interval, corrected QT interval (QTc) QT dispersion QTc dispersion, RR interval and QRS axis were measured in 12-lead surface electrocardiogram, once during fasting (10 to 11.5 hours of absolute fasting from food and liquid) and another time, 15 tp 60 minutes after eating food at sunset, All of the subjects had been fasting 11 to 12 hours each day at least for 25 days during Ramadan. The study was performed at Amir Alam hospital in the year 2000. Maximal QT interval, mean QT interval and RR-interval, were longer during fasting (P https://acta.tums.ac.ir/index.php/acta/article/view/2642 https://acta.tums.ac.ir/index.php/acta/article/download/2642/2624

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 100 104 "Mortazavi H Shariati B Zarrinpour N " 2015 09 28 This cross sectional study was carried out between 1993 to 1998 at Razi Skin Hospital, the affiliated Dermatology Department of Tehran University of Medical Sciences. Eight hundred patients receiving etretinate for various skin diseases took part in this study. Among them, 457 patients with first admission to dermatologic clinic who had at least four regular sequential visits and responding to our questionnaire were selected to enter the study for evaluating acute toxicity of etretinate. Cheilitis with a frequency of 88 percent was the most frequent side effect. Hair loss (22.97%), dry mouth with thirst (15.09%), dryness of mucous membranes (13.12%), xerosis with pruritus (11.15%), nose bleeding (8.31%), paronychia (5.47%), facial dermatitis (3.06%), conjunctivitis (2.84%) and in addition to mucocutaneous ones, chills (2.63%), headache (2.19%), mental depression (2.19%), urinary frequency (1.53%) and papilledema (0.44%) were among the other observed toxicities, The relationship between mucocutaneous side effect with dosage of etretinate, sex and, age of the patients was evaluated. The association between mucoctaneous toxicities and sex was significant, sex and, age of the patients was evaluated. The association between mucocutaneous toxicities and sex was significant (P https://acta.tums.ac.ir/index.php/acta/article/view/2643 https://acta.tums.ac.ir/index.php/acta/article/download/2643/2625

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 105 109 Ghaemmaghami F Behtash N Yarandi F Moosavi A Toogeh Gh.R Khanafshar N 2015 09 28 This study was designed to assess the role of first-line chemotherapy with 5-FU and platinum in the treatment of advanced or recurrent cervical cancer, ten patients with advanced or recurrent cancer of the cervix, with no prior chemotherapy were entered in phase II trial, from Oct. 2000 to Nov. 2001. Eight patients were treated with cis-platinum (50 mg/m2 over 60 minutes in first day) followed by 5-FU (1 g/m2 over 24 hours for 4 days) and two patients with impaired renal function were treated with carboplatin (300 mg/m2 over 15 minutes in first day) followed by 5-FU (1 g/m2 over 24 hours for 4 days) every three weeks, until progression of disease or prohibitive toxicity had been observed. Median age was 52 years (range: 28-70 years). Ten patients received a total of 42 cycles of chemotherapy. The mean number of chemotherapy cycles was 4.2 (median 4, range: 3-7). Three patients had partial response (30%, CI, 1.7%-58.5%). Mean response duration was 198 days (range: 122-273 days). Four patients required red blood cell transfusions; three of them had grade II and one of them grade III nausea and vomiting Two had fever and neutropenia (one developed acute renal insufficiency), and there wee no treatment related mortalities. First-line chemotherapy with platinum and 5-FU for advanced recurrent cervical cancer is promising and deserves consideration for large phase III trials. https://acta.tums.ac.ir/index.php/acta/article/view/2644 https://acta.tums.ac.ir/index.php/acta/article/download/2644/2626

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 110 112 Daie Ghazvini R Zaini F Zibafar E Omidi K 2015 09 28 Present paper reports a case of breast actinomycosis due to Actinomyces israelii in a 31-year-ol female nurse from Shahrekord, in Iran. Diagnosis was based on the observation of short and very fine gram-positive filaments in direct examination of aspirates from fistulas, as well as isolation of organism in sodium thioglycolate and brain heart infusion blood agar (BHIB) culture media, under anaerobic conditions and complementary phyiologic tests. https://acta.tums.ac.ir/index.php/acta/article/view/2645 https://acta.tums.ac.ir/index.php/acta/article/download/2645/2627

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 2 2003 06 15 113 121 Baghaie F Motahhary P 2015 09 28 Osteosarcoma is a primary malignant tumor of bone, which can involve jaws. This article reviews osteosarcoma of the jaws referred to the Department of oral pathology, dental faculty of Tehran University of Medical Sicences and Pathology Department of Cancer Institiute in Imam Khomeini Hospital during 30 years from 1349 to 1378 and also reviews jaw Osteosarcoma in English literature. The purpose of this review is comparing the clinical behaviour of jaw tumors with Osteosarcoma from elsewhere in the body and reporting the observations of clinical, histological and diagnostic findings. For this retrospective review the clinical, radiographic and histopathologic records of 42 patients were obtained, furthermore follow up results were also obtained from patients records. The mean age of patients was 35 years (range 9 to 61 years) with slight male predilection. The most common presenting features were swelling, pain and ulcer. Histologically, the lesions ranged from well-differentiated tumors with prominent osteoid formation to poorly differentiated tumors, which had bizarre cells and numerous mitosis especially atypical ones. Most of the lesions had areas of chondroid formation, but all of tumors showed neoplastic osteiod, of course in different degrees. The most important problem after treatment was local recurrence. Primary osteosarcomas of the jaws are a group of lesions, which are biologically distinct from long bones osteosarcoma and have better behaviour than them. More accurate determination of their clinical behaviour and their management will depend on complete follow up of patients and actual records of patients’ data. https://acta.tums.ac.ir/index required biopsies or endocervical curettage (ECC). Those with CIN I or worse lesions diagnosed by histology were considered true-positive. VIA results were positive in 191 women (16.1%) and cytology was abnormal (for ASCUS or worse lesions) in 226 women (19%). VIA and cytology detected 130 (74%, 95% CI: 68%-81%) and 126 (72%, 95% CI: 65%-79%) cases respectively, yielding a sensitivity ratio of 1.03. VIA detected 31 lesions which were cytologically negative and cytology detected 27 lesions which were negative by VIA; 18 cancerous and precancerous lesions were missed in both modalities. The approximate specificities of VIA and cytology were 94% (95% CI: 93%-95%) and 90.2% (95% CI: 88%-92%) respectively. Also, the positive predictive values were 68.1% (95% CI: 61%-75%) and 55.7% (95% CI: 49%-62%) respectively. These results indicate that VIA and cytology had very similar performance in detecting CIN I or worse lesions in this study. https://acta.tums.ac.ir/index.php/acta/article/view/2673 https://acta.tums.ac.ir/index.php/acta/article/download/2673/2655

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 4 2003 12 15 254 259 B. Vafaei A. Seidy 2015 09 28 This study has been designed to compare visual inspection of cervix with acetic acid (VIA test) with cytology as an accepted method for screening of cervical carcinoma and its precursors. 1200 eligible women were examined by both Pap-smear and VIA tests in Imam Khomeini Hospital, a referral general hospital in Tehran, Iran. Those who had abnormal results in one or both of the screening tests (n = 308) and those who had clinically suspicious lesions even if the tests were negative in addition to 10% of otherwise normal patients with negative tests (totally 290 patients) were referred for colposcopy and biopsy if mandated. From 598 patients who were introduced to colposcopy services, 355 patients required biopsies or endocervical curettage (ECC). Those with CIN I or worse lesions diagnosed by histology were considered true-positive. VIA results were positive in 191 women (16.1%) and cytology was abnormal (for ASCUS or worse lesions) in 226 women (19%). VIA and cytology detected 130 (74%, 95% CI: 68%-81%) and 126 (72%, 95% CI: 65%-79%) cases respectively, yielding a sensitivity ratio of 1.03. VIA detected 31 lesions which were cytologically negative and cytology detected 27 lesions which were negative by VIA; 18 cancerous and precancerous lesions were missed in both modalities. The approximate specificities of VIA and cytology were 94% (95% CI: 93%-95%) and 90.2% (95% CI: 88%-92%) respectively. Also, the positive predictive values were 68.1% (95% CI: 61%-75%) and 55.7% (95% CI: 49%-62%) respectively. These results indicate that VIA and cytology had very similar performance in detecting CIN I or worse lesions in this study. https://acta.tums.ac.ir/index.php/acta/article/view/2674 https://acta.tums.ac.ir/index.php/acta/article/download/2674/2656

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 4 2003 12 15 260 264 F. Safarpour D. Safarpour 2015 09 28 Cancer of the stomach carries poor prognosis. Surgery is the best treatment for gastric cancer. Prediction of survival depends on the stage at the time of presentation. Fluoroscopy, sonography, and computerized tomography are used for advanced gastric cancers staging, but they are not accurate enough to grade advanced gastric cancers. Laparoscopic findings of lesions under direct vision, are magnified 15 times and have been used for gastric cancer staging and more specific prediction. To demonstrate the importance of laparascopy, we carried out this study on 84 confirmed cases of gastric cancer prior to laparatomy. Results of computerized tomography were compared with the findings of laparascopies, and laparotomy was the gold standard in this study. Abdominal CT of gastric lesions had recommended resectability in 84 cases. Resectability was believed possible by laparoscopy only in 65 patients (19 false positives). Sixty-five patients were considered to have true positive diagnosis of resectability and one false negative and two false positive cases had false laparoscopic finding, which were confirmed by laparatomy and all of them were resectable. Eleven patients were diagnosed as stage IV because distant metastases were found during laparoscopy. This study showed that there are 42% differences between CT and laparoscopic findings. In this study the sensitivity and specifity of CT for stage II are respectively 77.7% and 82% but sensitivity and specifity of laparoscopy for stage III are respectively 78% and 55% and sensitivity and specifity of laparoscopy for stage III gastric cancer are respectively 94.5% and 100%. Laparoscopic examination is a valuable tool for diagnosing metastases and should be used for the management of advanced gastric cancers. We observed that 22% of patient had no need to undergo surgical operation, if they had pre-operative laparoscopic examination. This study suggests that terminally ill patients, and in advanced gastric cancer where surgery may be ineffective, laparascopic examination may predict and avoid unnecessary surgical interventions. https://acta.tums.ac.ir/index.php/acta/article/view/2675 https://acta.tums.ac.ir/index.php/acta/article/download/2675/2657

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 4 2003 12 15 265 268 Sh. Askarpour M.H. Sarmast shooshtary 2015 09 28 Intussusception is a common pediatric surgical emergency, but rarely seen postoperatively as a cause of obstruction. This complication occurs after abdominal, thoracic, orthopaedic and urologic operations. Ileus and obstruction due to adhesion band are the common causes of postoperative obstruction, however, although intussusception is less frequent but can be serious. We have to consider this diagnosis in pediatric age group. This study was done between 1983-2000 among 10 patients with postoperative intussusception. Primary operation in most cases was diaphragmatic operation (40%), and abdominal esophageal operation (20%), most being performed under the age 3 years. The interval between primary operation and initiation of symptoms and signs was less than 5 days in 60% of cases and the most common type of intussusception was ileoileal in 80% of cases. Since classic signs and symptoms of intussusception are frequently absent and diagnostic tools are less helpful, high degree of suspicious is required for early diagnosis. Timely operation can give excellent results. https://acta.tums.ac.ir/index.php/acta/article/view/2676 https://acta.tums.ac.ir/index.php/acta/article/download/2676/2658

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 41 4 2003