Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 591 598 EN Hussein Rastegar Food and Drug Research Center, Ministry of Health and Medical Education, Tehran, Iran. Hamidreza Ahmadi Ashtiani Department of Biochemistry and Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. AND Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University and Institue of Medicinal Plants, Tehran, Iran. AND Department of Nutritional Hygiene, Faculty of Veterinary, Tehran University of Medical Sciences, Tehran, Iran. Soghra Anjarani Reference Research Center Lab, Ministry of Health and Medical Education, Tehran, Iran. Saeed Bokaee Faculty of Veterinary Medicine, Tehran University of Medical Sciences, Tehran, Iran. Arash Khaki Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Leila Javadi Department of Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2015 10 11 Breast cancer is the most commonly diagnosed invasive malignancy and first leading cause of cancer-related deaths in Iranian women. Based on silymarin's unique characteristics, its application in chemotherapy combined with doxorubicin can be effective to enhance the efficacy together with a reduced toxicity on normal tissues. The present study focus on evaluate the efficacy of silymarin in combination with doxorubicin, on viability and apoptosis of estrogen-dependent breast carcinoma cell line (MCF-7). After being cultured, MCF-7 cells were divided into 8 groups and treated as follows: 1st group received 75 μg silymarin, groups 2, 3, and 4 were treated with 10, 25, and 50 nM doxorubicin, respectively, and groups 5, 6, and 7 respectively received 10, 25, and 50 nM doxorubicin as well as 75 μg silymarin. Viability percentage and apoptosis of the cells were assessed with Trypan Blue staining after 16, 24, and 48 hours. Silymarin has a synergistic effect on the therapeutic potential of doxorubicin. Use of silymarin in combination with doxorubicin can be more effective on the therapeutic potential of doxorubicin and decreases its dose-limiting side effects. https://acta.tums.ac.ir/index.php/acta/article/view/4369 https://acta.tums.ac.ir/index.php/acta/article/download/4369/4348

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 599 603 EN Ali Zare Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran. Mahmood Mahmoodi Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 In a good deal of studies cholesterol distribution, as a risk factor, demonstrates a special treatment towards age so that it shows an upward trend up to an age group and exhibits a downward trend for older age brackets thereafter. To investigate this phenomenon, two general points of view are presented. First, this issue may occur naturally for many subjects and it may be due to natural treatment of cholesterol variable with age. Second, it could be related to differential mortality, i.e. mortality changes in different age groups. In other words, it can be said that higher levels of cholesterol are relevant to younger-age mortality rate. Constructing a parametric model based on Weibull distribution, the association of this phenomenon with differential mortality was investigated. This study revealed that the effect of differential mortality on cholesterol distribution in the age groups younger than 65 were insignificant and it could partly be justifiable just in older age groups because it involves 35% changes in the 85-95 age groups. Thus, the differential mortality justifies just a part of cholesterol changes and other parts are due to intrinsic changes of cholesterol variable with time. https://acta.tums.ac.ir/index.php/acta/article/view/4368 https://acta.tums.ac.ir/index.php/acta/article/download/4368/4352

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 604 610 EN Zahra Ansari Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Sina Rafat Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammad Vahid Jorat Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mahdieh Ghanbari-Firoozabadi Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Masoud Mirzaei Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammadtaghi Sarebanhassanabadi Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2015 10 11 QT dispersion is an indicator of lack of ventricular repolarization homogeneity and an independent predictor for ventricular arrhythmia and sudden cardiac death. In this study, we evaluated the effect of inpatient cardiac rehabilitation on QT dispersion in patients admitted to Afshar hospital CCU with diagnosis of acute myocardial infarction (AMI), including ST elevation or non-ST elevation MI. Sixty patients with diagnosis of AMI were randomly divided into two 30-subject groups. The subjects in the first group were undergone inpatient cardiac rehabilitation, and the subjects in the control group received only conventional treatments. QT interval dispersion was measured in two occasions: once in the first day of admission and once before discharge from hospital. In this study there was a significant reduction in QT dispersion in patients undergoing inpatient cardiac rehabilitation (48.4 vs. 42.4 ms, P0.05). The reduction was not significantly different regarding gender. The effectiveness of the rehabilitation on the reduction of QT dispersion was not affected by such variables as age, gender, hypertension, positive family history, hyperlipidemia, type of AMI (with ST-elevation or non-ST-elevation) and left ventricular ejection fraction. Diabetes caused a resistance to the beneficial effects of inpatient cardiac rehabilitation, so as non-diabetic patients showed more reduction in QT dispersion in response to inpatient cardiac rehabilitation comparing non-diabetic patients and the difference was statistically significant. https://acta.tums.ac.ir/index.php/acta/article/view/4367 https://acta.tums.ac.ir/index.php/acta/article/download/4367/4356

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 611 614 EN Mojtaba Chardoli Sina Trauma and Surgery Research Center, Tehran University Medical Sciences, Tehran, Iran. Alireza Khajavi Sina Trauma and Surgery Research Center, Tehran University Medical Sciences, Tehran, Iran. Mohsen Nouri Sina Trauma and Surgery Research Center, Tehran University Medical Sciences, Tehran, Iran. Vafa Rahimi-Movaghar Sina Trauma and Surgery Research Center, Tehran University Medical Sciences, Tehran, Iran. 2015 10 11 As a significant number of patients diagnosed with transient ischemic attack (TIA) at emergency department are at risk to develop TIA or cerebral vascular accident (CVA), several attempts have been made to figure out a predictive method to detect those at higher risk of such attacks. We aimed to evaluate the role of ABCD2 scoring which includes age, blood pressure, clinical symptoms, diabetes mellitus, and duration of symptoms in predicting short term outcome of the patients presenting with TIA. One hundred consecutive patients visited between 2009 and 2010 in Hazrat Rasoul Akram Hospital and diagnosed with TIA were enrolled and their ABCD2 scores were registered. The incidence of death, CVA, or TIA during the first week after the attack was recorded. Eleven patients suffered new TIA/CVA after 1 week. Sensitivity and specificity of ABCD2 score for predicting CVA/TIA at cut-off point of 4 were 72.7% and 52.8%, respectively. At the same cut-off point for ABCD2, positive and negative predictive values were 16% and 94 %, respectively. Our results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA. Though ABCD2 as an easily applicable tool is very helpful in management of TIA patients at emergency department, but it should not be the only measure to rely on in our decision making. https://acta.tums.ac.ir/index.php/acta/article/view/4366 https://acta.tums.ac.ir/index.php/acta/article/download/4366/4358

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 615 619 EN Akefeh Ahmadiafshar Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. AND Pediatric Ward, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Sara Tabbekhha Pediatric Ward, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran, Noureddin Mousavinasab Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Parisa Khoshnevis Pediatric Ward, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran. 2015 10 11 Childhood asthma and obesity are significant public health problems. Most prospective studies suggest that obesity increases the risk of asthma. But, some authors did not found this association. In this study the association between asthma and body mass index (BMI) was investigated. This case-control study was conducted on 200 asthmatic children aged 6-15 years and 200 children without asthma. The criteria for asthma diagnosis and its classification were on the basis of National Asthma Education and Prevention Program (NAEPP). BMI of patients and controls were also measured and BMI grater than 85% and 95% were defined as overweight and obese respectively. The data was analyzed by SPSS software. The BMI among the asthmatic children (17.9 kg/m2) was higher than the BMI among the non-asthmatics (16.5 kg/m2), P=0.0001. This relationship was significant in both males and females. 18% of asthmatic children were classified as overweight and 13.5% of them were obese versus 7.5% and 6% respectively in non asthmatics (P=0.0001). However, there was no significant relationship between severity, duration of asthma, kind of medication and BMI in children with asthma (P>0.05). Result of this study showed that there is an association between asthma symptoms and obesity in children. Therefore, any attempts for weight control in asthmatic children might be beneficial. https://acta.tums.ac.ir/index.php/acta/article/view/4365 https://acta.tums.ac.ir/index.php/acta/article/download/4365/4360

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 620 625 EN Hassan Hashemi Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran. Mansour Taherzadeh Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran. Mehdi Khabazkhoob Dezful University of Medical Sciences, Dezful, Iran. 2015 10 11 To assess the one year results of Artiflex Phakic intraocular lens (IOL) implantation in the treatment of high myopia. In this non-random interventional study, myopic patients with spherical equivalent worse than -5.0 diopters (D) who were not eligible for laser surgery were assessed. All patients had refraction, uncorrected and best corrected visual acuity tests (UCVA and BCVA), endothelial cell count (ECC), and measurement of the anterior chamber depth and intraocular pressure before surgery and at 1, 3, 6, and 12 months after surgery. Main outcome measures of this study were refractive stability, refractive predictability, safety, and efficacy after implanting Artiflex IOLs. We studied 53 eyes of 20 female and 8 male patients. The mean preoperative spherical equivalent was -10.22±3.02 D which reached -0.69±1.08 D one year after surgery (P<0.001). On the last follow-up visit, 75% of the eyes were within +0.5 D of emmetropia, 2 eyes had lost one line of BCVA, 18.75% had gained one line and 31.25% had gained 2 or more lines of BCVA. Others showed no change in BCVA. At one year after surgery, 72.2% of the eyes had 20/25 vision or better. The safety and efficacy indices were 1.16 and 1.05, respectively. ECC showed 3.04% decrease (P=0.176). In cases where laser surgery is not an option for myopic patients, use of Artiflex IOLs can have good results with acceptable safety and efficacy. https://acta.tums.ac.ir/index.php/acta/article/view/4364 https://acta.tums.ac.ir/index.php/acta/article/download/4364/4362

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 626 632 EN Ali Davati Department of Social Medicine and Health, Faculty of Medicine, Shahed University, Tehran, Iran. Ashraf Pirasteh Department of Social Medicine and Health, Faculty of Medicine, Shahed University, Tehran, Iran. Maryam Yahyaei Department of Social Medicine and Health, Faculty of Medicine, Shahed University, Tehran, Iran. Afsaneh Shakouri Department of Social Medicine and Health, Faculty of Medicine, Shahed University, Tehran, Iran. 2015 10 11 Skin cancer is the most prevalent type of cancer in most of the countries and more than 90% of cancer cases are related to ultra violet rays of the sun. Therefore protective behaviors against sunlight are considered the most essential measures for skin cancer prevention. This study has been conducted to determine the frequency of protective behavior against sunlight among female students of Tehran city high schools. The Health Belief Model has been used for this cross-sectional study to analyze the factors related to protective behaviors. A multi-phase sampling method was used. 941 female student of Tehran city high schools were studied using a probed question form. The data were then analyzed using SPSS software. During the study of protective behaviors against the sunlight, 24.7% of participants mentioned that they always use sunscreen. The behavior of using sunscreen is related to perceived sensitivity, severity and benefit amongst the students (P<0.05). Also 3.8% of the students who participated in our study were always using gloves in summer to protect against sunlight. The behavior of using gloves in summer was also related to perceived sensitivity, severity and benefit (P<0.05). Physicians were the most effective influencing people with 84.9% influence on the appropriate decision making by these students. There is a low frequency of protective behavior against sunlight among the female students of Tehran city high schools. These findings show the necessity of training the students in this regard and promote the protective behaviors amongst them. https://acta.tums.ac.ir/index.php/acta/article/view/4363 https://acta.tums.ac.ir/index.php/acta/article/download/4363/4366

Tehran University of Medical Sciences Acta ge>789 792 EN Mahbod Kaveh Department of Neonatology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Tahereh Esmailnia Department of Neonatology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Nayeri Department of Neonatology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Firoozeh Nili Department of Neonatology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Davari Tanha Department of Obstetrics &Gynecology , Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahsa Ghajarzdeh Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) less than 15mg/dl enrolled in this study. Thymine-adenine (TA)  repeats in the promoter region of UGT1A1 gene investigated by means of  polymerase- chain reaction (PCR) DNA sequencing. Demographic characteristics did not differ significantly between groups while STB was higher in case group (17.5±1.9 vs. 10.4±1.8, p value<0.001). Among one hundred neonates evaluated in this study, TA6/6, TA6/7 and TA7/7 genotypes found in 52%, 42% and 6%, totally. TA6/7 and TA7/7 genotypes observed in case group more than the control group (P<0.001). STB levels were significantly higher in cases with TA6/7 and TA7/7 genotype pattern (P<0.001). Heterozygous and variant homozygous genotypes of the promoter region of UGT1A1 gene in healthy Iranian neonates with idiopathic hyperbilirubinemia should be considered. https://acta.tums.ac.ir/index.php/acta/article/view/4347 https://acta.tums.ac.ir/index.php/acta/article/download/4347/4487

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 11 2013 11 15 793 798 EN Fatemeh Fathi Department of Occupational Medicine, Shahid Rahnamoun Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Moslem Jafarpoor Department of Occupational Medicine, Shahid Rahnamoun Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2015 10 11 Skin disorders comprise more than 35% of all occupationally related diseases. 90-95% of work-related dermatoses are contact dermatitis. Effects of occupational dermatitis in the lives of workers are substantial. To plan any preventive program we need basic statistics of the problem, that we had no reliable one which includes a lot of industries in Iran. Therefore we decided to determine occupational contact dermatitis, and it's subtypes prevalence in various jobs. The objective of this study is determination of occupational contact dermatitis, and it's subtypes prevalence and comparison among various jobs. In this cross -sectional study, we examined 3061 workers of various industries during 2007-2012 and recognized contact dermatitis cases. Irritant and allergic cases were separated according to clinical judgment of physician and patch test using European standard series. We found 271 (prevalence=8.8%) occupational contact dermatitis cases which 247 (91.1%) were irritant, and the rest were allergic. The highest prevalence was in washing powder production and then glaze and paint workers, mechanists and chemical workers were located. There is a great variability for occupational contact dermatitis in various industries and between different countries. These statistics changes during the time by changing in number of workers and their characteristics, variation in material and process and glove use situation. So every country must have a national data bank of occupational contact dermatitis, which must be updated after a period of time. https://acta.tums.ac.ir/index.php/acta/article/view/4346 https://acta.tums.ac.ir/index.php/acta/article/download/4346/4488

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 11 2013 11 15 799 804 EN Ali Akbar Fallahi Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Parivash Korbacheh Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Farideh Zaini Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Hossein Mirhendi Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Hojjat Zeraati Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Noorbakhsh Department of Biology, Islamic Azad University, Varamin-Pishva Branch, Varamin, Iran. Maryam Moazeni Invasive Fungi Research Center, Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Laris Andonian Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Nazeri Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Sassan Rezaie Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Due to the epidemiological alteration in distribution of Candida species as well as significant increasing trend of either intrinsic or acquired in resistance of some of these fungi, the precise identification of Candida species is necessary for effective antifungal therapy and also for prevention of nosocomial infections. PCR-RFLP method is indicated to be a reliable, rapid and simple technique which is able to differentiate the Candida species. In the present study, we applied this method to evaluate the distribution of Candida species in patients affected with cutaneous candidiasis in the Guilan province. 896 clinical cutaneous samples were collected from different parts of skin and nail of suspected patients referred to clinical centers all over the Guilan province during 24 months. Samples were examined directly with 15% KOH and cultured on fungal specific media. Genomic DNA was extracted and the restriction enzyme Msp1 was applied for polymorphism analysis. Totally, 47 yeast strains were successfully isolated from different clinical samples and identified by conventional as well as PCR-RFLP methods. The results indicated that Candida albicans (36.17%) was the most frequent species followed by C. parapsilosis (25.53%), C. tropicalis (19.14%), C. guilliermondii (14.89%), C. famata (2.12%) and C. krusei (2.12%). Female finger nails were the most common location to be affected by Candida species. In conclusion, PCR-RFLP method was successfully used for recognition of clinical Candida species within the Guilan province and obtained results revealed C. albicans as the predominant causative agent of cutaneous candidiasis. However, distribution of other Candida species did not completely consist with the reported distribution of Candida species in other parts of Iran with different climate to the Guilan province. https://acta.tums.ac.ir/index.php/acta/article/view/4345 https://acta.tums.ac.ir/index.php/acta/article/download/4345/4490

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 11 2013 11 15 805 810 EN Maryam Azizzadeh Department of Dermatology, Semnan University of Medical Sciences, Semnan, Iran. Morteza Rezaei Department of Pediatrics, Semnan University of Medical Sciences, Semnan, Iran. Nargess Hashemi Department of Pediatrics, Semnan University of Medical Sciences, Semnan, Iran. 2015 10 11 Incontinentia Pigmenti (IP) is a rare X-linked dominant disorder with skin, eye, central nervous system (CNS) and tooth abnormalities. According to the reported cases, it is estimated that there have been nearly 900-1200 affected individuals. In this article, the literature is reviewed and a case of IP with characteristic skin lesions and optic atrophy is presented. https://acta.tums.ac.ir/index.php/acta/article/view/4344 https://acta.tums.ac.ir/index.php/acta/article/download/4344/4492

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 11 2013 11 15 811 813 EN Farzad Omidi-Kashani Department of Orthopedic, Orthopedic Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Ebrahim Ghayem Hasankhani Department of Orthopedic, Orthopedic Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. 2015 10 11 A 25-year old man presented with chronic low back pain for about 5 years due to mild congenital lumbar kyphosis (L1-L3 25° with congenital posterior wedge vertebra L2). Preoperative neurologic examination was normal. After posterior spinal fusion and instrumentation with moderate curve correction, the patient gradually developed the symptoms and signs of cauda equina syndrome due to intraoperative L2-3 disc herniation. After 5 days the patient underwent posterior decompression surgery and on the latest follow up visit at 2 years later, nearly all the motor power was recovered but the patient complained of occasional urinary incontinence and residual right leg paresthesia. In surgical treatment of congenital kyphosis, much attention should be paid to the presence of contemporaneous asymptomatic disc herniation. https://acta.tums.ac.ir/index.php/acta/article/view/4343 https://acta.tums.ac.ir/index.php/acta/article/download/4343/4495

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 11 2013 11 15 814 815 EN Esfandiar Shojaei Department of Infectious Diseasses, Tehran University of Medical Sciences, Tehran, Iran. Zahra Abdi Layali Department of Infectious Diseasses, Tehran University of Medical Sciences, Tehran, Iran. Sirous Faraji Hormozi Department of Infectious Diseases, Army University of Medical Sciences, Tehran, Iran. Pardis Moradnejad Department of Infectious Diseasses, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Intestinal tuberculosis is an uncommon presentation of tuberculosis (TB) and has clinicopathological similarities with Crohn's disease. In regions where TB is endemic clinicians must aware of this condition and fully evaluate their patients when Crohn's disease is diagnosed. We recommend all pathologic specimens be evaluate effectively for TB.Smear, culture and PCR for Mycobacterium.tuberculosis from samples aside the pathological reviews help for better diagnosis. Here we present a case of intestinal tuberculosis which initially diagnosed as Crohn's disease but after starting immunosuppressive agents he presented with disseminated tuberculosis. https://acta.tums.ac.ir/index.php/acta/article/view/4342 https://acta.tums.ac.ir/index.php/acta/article/download/4342/4497

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 11 2013 11 15 816 818 EN Askin Esen Hasturk Department of Neurosurgery, Oncology Training and Research Hospital, Ankara, Turkey. Mehmet Basmaci Department of Neurosurgery, Oncology Training and Research Hospital, Ankara, Turkey. 2015 10 11 Gelatin sponge, oxidized cellulose and microfibrillar collagen are used to achieve hemostasis during neurosurgical procedures. Hemostatic agents may produce clinically symptomatic, radiologically apparent mass lesions. The differential diagnosis should include the foreign body along with recurrent tumor. We present a case of intracranial hemostatic agents found in a 56-year-old male patient seven years after undergoing a craniotomy for a left posterior parietal convexity meningioma. Preoperative magnetic resonance imaging (MRI) suggested the presence of a recurrent tumor. We emphasize that although it is rare, a granuloma due to a foreign body reaction can result in a false image of tumor recurrence. https://acta.tums.ac.ir/index.php/acta/article/view/4341 https://acta.tums.ac.ir/index.php/acta/article/download/4341/4501

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 11 2013 11 15 819 821 EN Maryam Nakhaeimoghadam Research Center for Children and Adolescents Health, Zahedan University of Medical Sciences, Zahedan, Iran. Parastoo Rostami Department of Pediatric Endocrinology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Ameneh Zare-Shahabadi Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mehrzad Mehdizadeh Department of Pediatric Radiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Ali Rabbani