Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 7 2013 07 15 431 437 EN Seyed Behzad Jazayeri Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Masoumeh Firouzi Tissue Repair Laboratory, Institute of Biochemistry and Biophysics (IBB), Tehran University of Medical Sciences, Tehran, Iran. Shayan Abdollah Zadegan Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Research Centre for Neural Repair, Tehran University of Medical Sciences, Tehran, Iran. Niloufar Saeedi Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. Elham Pirouz Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mohsen Nategh Research Centre for Neural Repair, Tehran University of Medical Sciences, Tehran, Iran. Issa Jahanzad Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ahmad Mohebbi Ashtiani Research Centre for Neural Repair, Tehran University of Medical Sciences, Tehran, Iran. Vafa Rahimi-Movaghar Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Research Centre for Neural Repair, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Prior animal models have shown that rats sustaining 3-second immediate spinal cord compression had significantly better functional recovery and smaller lesion volumes than rats subjected to compression times of 1 hour, 6 hours, 3 weeks, and 10 weeks after spinal cord injury. We compare locomotor rating scales and spinal cord histopathology after 3 seconds and 10 minute compression times. . Ten rats were assigned into two early (3-second) and late (10-minute) compressive surgery groups. Compressive injury was produced using an aneurysmal clip method. Rats were followed-up for 11 weeks, and behavioral assessment was done by inclined plane test and tail-flick reflex. At the end of the study, the rats were sacrificed, and spinal cord specimens were studied in light and EM. Basso, Beattie and Bresnahan (BBB) locomotor rating scales were significantly better in the early compression group after the 4th week of evaluation (P<0.05) and persisted throughout the remainder of the study. Histopathology demonstrated decreased normal tissue, more severe gliosis and cystic formation in the late group compared to the early group (P<0.05). In EM study, injuries in the late group including injury to the myelin and axon were more severe than the early compression group, and there was more cytoplasmic edema in the late compression group. Spinal cord injury secondary to 3-second compression improves functional motor recovery, spares more functional tissue, and is associated with less intracellular edema, less myelin and axon damage and more myelin regeneration in rats compared to those with 10 minutes of compression. Inclined plane test and tail-flick reflex had no significant difference. https://acta.tums.ac.ir/index.php/acta/article/view/4416 https://acta.tums.ac.ir/index.php/acta/article/download/4416/4581

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 7 2013 07 15 438 443 EN Mehdi Sanatkar Department of Anesthesiology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Anesthesiology, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mostafa Sadeghi Department of Anesthesiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Nafiseh Esmaeili Autoimmune Bullous Disease Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Hossein Sadrossadat Department of Anesthesiology, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mehrdad Shoroughi Department of Anesthesiology, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Shahrokh Ghazizadeh Autoimmune Bullous Disease Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ebrahim Khoshraftar Department of Anesthesiology, Besat Hospital, Hamedan University of Medical Sciences, Hamedan, Iran. Hassan Pour Anvari Department of Anesthesiology, Besat Hospital, Hamedan University of Medical Sciences, Hamedan, Iran. Nasim Alipour Department of Anesthesiology, Besat Hospital, Hamedan University of Medical Sciences, Hamedan, Iran. 2015 10 11 The aim of this study was to assess the effect of spinal block with low dose of bupivacaine and sufentanil on patients with low cardiac output who underwent lower limb surgery. Fifteen patients who had ejection fraction less than 40% (group 1) were compared with 65 cases with ejection fraction more than 40% (group 2) in our study. Our subjects underwent spinal block with 7.5 mg hyperbaric bupivacaine 0.5% and 5 µg sufentanil. We recorded early events such as hypotension, bradycardia, vasopressor need and ST segment change in our cases. The average mean arterial pressure decreased 13% (110 mmHg to 95.7 mmHg) in group 1 and 20% (160 mmHg to 128 mmHg) in group 2 (P<0.001). Hypotension due to spinal anesthesia was observed in none of our subjects in both groups and none of our cases need to vasopressor support. All patients remained alert, and no ST segment changes were observed in two groups. In our study none of subjects complained of pain intraoperatively. The subjects were without complaints during the spinal anesthetic in both groups. Spinal block with low dose local anesthetic and sufentanil was a safe and effective method for lower limb surgery in patients with low ejection fraction. https://acta.tums.ac.ir/index.php/acta/article/view/4415 https://acta.tums.ac.ir/index.php/acta/article/download/4415/4583

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 7 2013 07 15 444 448 EN Alireza Eajazi Akhtar Orthopedic Research Center, Akhtar Orthopedic Hospital, Shahid Beheshti Medical University, Tehran, Iran. Firooz Madadi Department of Orthopedic Surgery, Akhtar Orthopedic Hospital, Shahid Beheshti Medical University, Tehran, Iran. Firoozeh Madadi Department of Medicine, Shahid Beheshti Medical University, Tehran, Iran. Majid Boreiri Department of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 The aim of this study is to compare three modes of femoral fixation, namely Aperfix, Rigidfix and Endobutton, in anterior cruciate ligament (ACL) reconstruction. 120 patients were randomly assigned to three groups, each consisting of 40 patients, and each group was treated by one of the above mentioned methods of femoral fixation. All patients were examined prior to and 24 months after surgery, and they were compared for anterior tibial displacement using the Lysholm score and KT-1000. The three modes of femoral fixation were not significantly different in terms of time of surgery. In the Endobutton group, the Lysholm score rose from 63.21±18.59 prior to ACL reconstruction to 90.64±9.47 after the surgery, while it rose from 65.72±18.74 to 96.22±5.35 in the Aperfix group and from 69.21±17.45 to 90.64±9.47 in the Rigidfix group. Anterior tibial displacement was 3.96±1.58 mm for Endobutton, 4.28±1.48 mm for Rigidfix and 4.03±1.79 mm for Aperfix. Aperfix was indicated to yield a better outcome in terms of instant stability and general results. https://acta.tums.ac.ir/index.php/acta/article/view/4414 https://acta.tums.ac.ir/index.php/acta/article/download/4414/4584

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 7 2013 07 15 449 453 EN Hamid Emadi Koochak Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran. Setareh Davoudi Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran. Abbas Salehi Omran Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Reyhaneh Mohsenipour Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Keveh Hajifathalian Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Behtash Saeidi Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Ali Akbar Amirzargar Molecular Immunology Research Center, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran. Maryam Sotoudeh Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Soroush Seifirad Department of Pediatric Cardiology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Tuberculosis pericarditis as a potentially fatal complication of tuberculosis requires effective diagnosis and treatment. We evaluated the efficacy of interferon-gamma (IFN-gamma) and adenosine deaminase (ADA) for diagnosing tuberculosis pericarditis in a cohort of Iranian patients presenting with pericarditis. We enrolled 38 patients with presentation of pericarditis. All patients underwent diagnostic and therapeutic pericardiostomy with drainage and biopsy. Adenosine deaminase and interferon-gamma levels were determined in pericardial fluid samples of all patients. Pericardial tissue samples were submitted for histopathologic and microbiologic studies. Polymerase chain reaction (PCR) was performed on all pericardial fluid samples to detect Mycobacterium tuberculosis. From 38 patients with pericarditis, 7 cases were diagnosed as having tuberculosis pericarditis (18.4%). Mean concentration of interferon-gamma in tuberculosis group was significantly higher compared to non-tuberculosis group (69257 pg/l [range: 26600-148000] vs. 329 pg/l [range: 0-2200], P<0.000). Receiver operating characteristic (ROC) curve showed a value of 14400 pg/l as the cutoff point with a sensitivity of 100% and specificity of 100% for diagnosing tuberculosis pericardial effusion. Adenosine deaminase was not found to be significantly higher in tuberculosis group in comparison with non-tuberculosis causes of pericardial effusion (35.7 [range: 9-69] vs. 36.03 [range: 8-420], P=0.28). In this study interferon-gamma showed to be a valuable diagnostic test for detection of tuberculosis pericarditis among a cohort of Iranian patients. We suggest using interferon-gamma to diagnose tuberculosis pericarditis to make diagnose in case of suspicion. While in this study, adenosine deaminase measurement did not prove to have the characteristics of an accurate diagnostic test for tuberculosis pericarditis. https://acta.tums.ac.ir/index.php/acta/article/view/4413 https://acta.tums.ac.ir/index.php/acta/article/download/4413/4586

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 7 2013 07 15 454 460 EN Mohammad Jalili Department of Emergency Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Hasan Barzegari Department of Emergency Medicine, School of Medicine, Ahwaz University of Medical Sciences, Ahwaz, Iran. Nasimi Pourtabatabaei Department of Emergency Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Amir Reza Honarmand Department of Emergency Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Majid Boreiri Department of Emergency Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Amir Mehrvarz Department of Emergency Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Zahra Ahmadinejad Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Sepsis constitutes an important cause of hospital admission with a high mortality rate. Appropriate antibiotic therapy is the cornerstone of therapy in patients with sepsis. Although numerous studies have recommended early antibiotic initiation in severe sepsis or septic shock stages of sepsis syndrome, its role in treatment of patients with sepsis who have not entered these stages remains to be investigated. The purpose of this study is to investigate the effect of door-to-antibiotic time in sepsis patients with various degrees of severity. This is a longitudinal prospective cohort study on adult patients admitted with sepsis to the emergency department. Sepsis was defined as presence of at least two criteria of systemic inflammatory response syndrome and procalcitonin levels ≥ 2μg/l. Severity of sepsis was determined using the APACHE II (Acute Physiology and Chronic Health Evaluation II) scoring system. Time to antibiotic administration was recorded and its relationship with mortality was assessed. A total of 145 patients were eligible for enrollment. The mean age was 60.4 years and the mean APACHE score was 13.7. The overall in-hospital mortality was 21.4%, and the mean length of stay in hospital was 211.9 hours. The mean door-to-antibiotic time for our patients was 104.4 minutes. Antibiotic administration time and mortality in patients with APACHE scores of 21 or higher (P=0.05) were significantly related; whereas such a relationship was not observed for patients with APACHE scores of 11- 20 (P=0.46). We observed early antibiotic initiation for patients in sepsis phase with higher severity scores was associated with significant improvement in survival rate. https://acta.tums.ac.ir/index.php/acta/article/view/4412 https://acta.tums.ac.ir/index.php/acta/article/download/4412/4587

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 7 2013 07 15 461 466 EN Ata Mahmoodpoor Department of Anesthesiology and Intensive Care, General ICU, Shohada Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Ali Peyrovi-far Department of Anesthesiology and Intensive Care, General ICU, Shohada Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Hadi Hamishehkar Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz Uniow transplantation research center. Baseline information and also data related to fever and neutropenia, patient's outcomes, duration of hospitalization and antibiotic use pattern were documented.A total of 195 patients were analyzed and a total of 268 febrile episodes in 180 patients were recorded (mean 1.5 episodes per patient). About 222 episodes (82%) were associated with neutropenia which one-fourth of them were without any documented infection sources. Microbiologic documents showed that the relative frequencies of gram positive and gram negative bacteria were 62.5% and 37.5%, respectively. The hospital stay duration was directly related to the numbers of fever episodes (P<0.0001).The rate of febrile episodes in autologous stem cell transplantation was significantly higher compared to allogeneic type (P<0.05).It is necessary to determine not only the local profile of microbiologic pattern, but also antibiotic sensitivities in febrile neutropenic patients following hematopoietic stem cell transplantation, and reassess response to antibiotic treatment to establish any necessity for modifications to treatment guidelines in order to prevent any fatal complications from infection. https://acta.tums.ac.ir/index.php/acta/article/view/4742 https://acta.tums.ac.ir/index.php/acta/article/download/4742/4563

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 43 45 EN Siamak Afshinmajd Neurophysiology Research Center, Shahed University, Tehran, Iran. Ali Davati Department of Social Medicine, Shahed University, Tehran, Iran. Afshin Ahmadvand Department of Psychiatry, Kashan University of Medical Sciences, Kashan, Iran. Farhad Modara Department of Neurology, Ilam University of Medical Sciences, Ilam, Iran. Masoud Moghaddamnia Department of Psychiatry, Shahed University,Tehran , Iran. Moslem Jaberian Physician, Graduated from Shahed University, Tehran, Iran. 2015 10 11 Lumbar puncture (LP) is a procedure for obtaining spinal fluid from spinal meningeal spaces this can be done as a diagnostic or therapeutic procedure which can result in to a typical positional headache named as post lumbar puncture headache .This can cause a lot of discomforts for patients and makes fear from the procedure. This study designed to evaluate the effect of resting position after LP on post lumbar puncture headache (PLPH). Patients who had a diagnostic lumbar puncture were divided randomly in two groups .Group A patients had one hour rest in the supine position while group B patients had one hour rest in the prone position. Both groups followed for appearance of symptoms of PLPH for 5 days. 119 patients completed the study, 57 (48%) male patients and 62 (52%) female .PLPH totally appeared in 38 (31.9%) patients .In the group A PLPH was present in 20 patients whereas in group B it was present in 18 patients. Statistical analysis showed no significant differences between two groups (P>0.07). Position of rest after LP has no significant effect on reducing post lumbar puncture headache and there is no need to emphasize on position of rest after LP. https://acta.tums.ac.ir/index.php/acta/article/view/4740 https://acta.tums.ac.ir/index.php/acta/article/download/4740/4564

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 46 48 EN Fatemeh Davari-Tanha Department of Obstetrics & Gynecology & Reproductive Endocrinology, Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. Batool Hosseini Rashidi Department of OBS&GYN& Reproductive Endocrinology, Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mahsa Ghajarzadeh Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. Ahmad Ali Noorbala Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Science, Tehran, Iran. 2015 10 11 This study was designed to determine the prevalence of bipolar disorder in women with polycystic ovarian syndrome (PCO). One hundred and ten women with definite diagnosis of PCO and one hundred and ten age-matched infertile women due to other reasons except for PCO were enrolled in this case-control study. Ten ml fasting venous blood sample obtained to measure fasting glucose, LH and FSH. Height, weight and waist-to-hip ratio (WHR) were also recorded by an expert technician. A psychiatrist examined all 220 cases in order to determine the prevalence of depression and bipolarity. Mean age of each group participants were not significantly different while FBS, LH and LH/FSH levels were significantly higher in PCO patients. Eighty eight case were depressed in PCO group while 96 were depressed in control group (P=0.03). Bipolar disorder were higher in PCO group in comparison with controls (8 vs. 0, P=0.004). Psychiatric disorders should be considered in PCO women. https://acta.tums.ac.ir/index.php/acta/article/view/4738 https://acta.tums.ac.ir/index.php/acta/article/download/4738/4565

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 49 51 EN Ahmad Ghanizadeh Department of Psychiatry, Research Center for Psychiatry and Behavioral Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 2015 10 11 This study examines the association of father's and mother's age with the severity of inattention and hyperactivity/impulsivity. Participants are 470 children with attention deficit hyperactivity disorder (ADHD) diagnosed according to DSM-IV diagnostic criteria. Moreover, parents reported the severity of ADHD symptoms through completing ADHD checklist. Mother's and father's age was associated with the score of hyperactivity/impulsivity. Lower father's age and advanced maternal age are associated with higher severity of hyperactivity/impulsivity in children and adolescents with ADHD. None of mothers' and fathers' age is associated with ADHD inattentiveness severity in children. Maternal and paternal education levels are not associated with ADHD severity. Older mothers and younger fathers have ADHD children with higher hyperactivity/impulsivity severity. It should be investigated whether the father's and mother's age are risk factors for ADHD. https://acta.tums.ac.ir/index.php/acta/article/view/4736 https://acta.tums.ac.ir/index.php/acta/article/download/4736/4566

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 52 55 EN Melike Yüceege Dışkapı Yıldırım Beyazıd Educational and Research Hospital, Respiratory Medicine Clinic, Ankara, Turkey. Berrin Sanisoğlu Bağcılar Governmental Hospital, Respiratory Medicine Clinic, İstanbul, Turkey. Reha Baran Acıbadem Fulya Hospital, Respiratory Medicine Clinic, İstanbul, Turkey. 2015 10 11 The study was aimed to investigate the diagnostic differences between male and female patients in pulmonary tuberculosis in a tertiary 660 bedded Educational Respiratory Medicine Hospital, Istanbul, Turkey. A retrospective study was conducted with the new diagnosed, 50 men and 50 female pulmonary tuberculous patients. Age, symptoms, personal history, radiologic and sputum smear findings were collected from their files. 44 male and 42 female patients were enrolled to the study. Male patients tended to be older, smoke more, get alcohol more, lose weight more and have sputum smear positivity more than the female patients. Neither the time of diagnosis nor the radiologic appearance differed statistically. The radiologic appearance, not the clinic symptoms, help to diagnose tuberculosis in female patients; especially in those with no weight loss and sputum smear negativity. https://acta.tums.ac.ir/index.php/acta/article/view/4734 https://acta.tums.ac.ir/index.php/acta/article/download/4734/4568

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 56 59 EN Sedigheh Soleimani Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Shahverdy Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Najmeh Mazhari Department of Food Science and Technology, Islamic Azad University, Science and Research Branch, Tehran, Iran. Khosrou Abdi Department of Drug Chemistry, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Siavash Gerayesh Nejad Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Sedigheh Shams Department of Medicine, Pathology Department, Tehran University of Medical Sciences, Tehran, Iran. Elham Alebooyeh Department of DDS, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Shahnaz Khaghani Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 It is obvious that lead intake is of concern not for its beneficial/essential effects on metabolism, but rather for its toxic actions, which can be especially damaging to children. The objective of this study was to analyze the concentration of lead in milk of mothers during prolonged lactation. Milk samples from 43 mothers were collected at 2 months postpartum. Lead was analyzed using atomic absorption spectrophotometer. The value of lead in human milk was 23.66±22.43 μg/l. Lead concentration in human milk of mothers was higher than other countries and no significant relationship was found between levels of human milk lead and mother's education, age, parity, height and weight. The concentrations of lead in the milk samples were high, which makes a major public health hazard for the inhabitants, especially neonatal and children, of the industrial locations. https://acta.tums.ac.ir/index.php/acta/article/view/4731 https://acta.tums.ac.ir/index.php/acta/article/download/4731/4569

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 60 65 EN Mohammad Ramin Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Javad Salimi Department of Vascular Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Alipasha Meysamie Department of Community and Preventive Medicine, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Buerger's disease or thromboangiitis obliterans (TAO) seems to be common in IR Iran, The present study aimed to evaluate an Iranian population with Buerger's disease in order to suggest a diagnostic criterion for Buerger's disease based on the most frequent findings and to compare it with Papa diagnostic criteria. In a cross-sectional study, all patients with resting limb pain, limb ischemic ulcers, intermittent claudication and limb ischemia who referred to the Vascular Clinic of Sina Hospital during 2009-2011 were evaluated. The patients were allocated to Buerger's and non-Buerger's groups; Evaluating 122 patients (61 in each group), according to the model each clinical manifestations and risk factors in the patients with Buerger's disease obtained a score. Absent pulsation, abnormal distal Doppler sonography and ischemic ulcer were respectively present in 58 (95.1%), 58 (95.1%) and 49 (80.3%) individuals with Buerger's disease. Multivariate linear regression analysis and multivariate logistic regression analysis were used for modeling. Considering the model finding findings, diagnostic criteria including age, sex, smoking, Raynaud's phenomenon, abnormal proximal Doppler, diabetes mellitus and hyperlipidemia were suggested (R2=0.582); the sensitivity and specificity of the criteria was respectively 95.1% and 78.7%. Compared with Papa criteria, Kappa coefficient was measured at 0.66 with a P-value<0.001. It seems that the recommended criteria have an acceptable accuracy in diagnosing Buerger's disease, especially in the Iranian population; however, it is necessary to conduct more studies with larger sample sizes to evaluate the criteria, especially in other populations. https://acta.tums.ac.ir/index.php/acta/article/view/4730 https://acta.tums.ac.ir/index.php/acta/article/download/4730/4571

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 66 75 EN Giti Shams Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Yaghoob Esmaili Department of Psychology, Islamic Azad University Rodhen Branch, Rodhen, Iran. Narges Karamghadiri Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Narges Ebrahimhkani Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Youness Yousefi Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.. Dean McKay Department of Psychology, Fordham University, USA. 2015 10 11 The Obsessive Beliefs Questionnaire-44 (OBQ-44), a self-report measure, was developed by the Obsessive Compulsive Cognitions Working Group (OCCWG) to assess beliefs considered relevant in the etiology and maintenance of obsessions and compulsions. The purpose of this study was to evaluate the psychometric properties of the Persian language version of the Obsessive Beliefs Questionnaire (POBQ-44). A sample of 222 medical students from an Iranian university was used to assess the reliability and validity of the POBQ-44. The results indicated five factors: 1) general, 2) perfectionism, certainty, 3) responsibility and threat estimation, 4) importance and control of thoughts, 5) complete performance. Each of these factors was found to have adequate test-retest and internal consistency reliability. Each of the factors was associated with O-C symptoms. In addition, adequate convergent validity was found with a measure of obsessive compulsive symptoms, and discriminate validity was found with measures of depression and anxiety. https://acta.tums.ac.ir/index.php/acta/article/view/4729 https://acta.tums.ac.ir/index.php/acta/article/download/4729/4577

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 76 81 EN Sarah Mousavi Department of Clinical Pharmacy and pharmacy practice, Faculty of Pharmacy and pharmaceutical sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Ava Mansouri Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran. Zahra Jahangard-Rafsanjani Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Amir Sarayani Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran. Molouk Hadjibabaie Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Kheirollah Gholami Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Inappropriate use of drugs is a widespread problem with serious consequences such as increased adverse drug reaction and antimicrobial resistance. Proper interventions would have important financial and public health benefits. Several studies have been performed about Rational Drug Use (RUD) in Iran. To provide a picture of researches were done about RUD and highlight the existing gaps in practice in Iran, a systematic search was conducted by reviewing all papers (English and Persian) found by searching keywords in Pubmed, Web of Science, Google Scholar, CINAHL, Proquest, International Pharmaceutical Abstract (IPA), SID, Iran Medex and MagIran. Retrieved articles were extracted in Access form and exported to Excel for further analysis. After excluding duplicate and irrelevant articles, 466 related articles were remained. Number of publications increased dramatically after 2001. About 73% of studies were cross-sectional. Evaluation of prescribing pattern (15%), self-medication (11.3%) and adverse drug reaction (9.1%) were among the top topics which were studied. Despite an increasing trend in RUD publications in Iran, still large gaps remain to be investigated. Knowing the existing gaps is crucial for policy makers to make investments to solve the problems. https://acta.tums.ac.ir/index.php/acta/article/view/4727 https://acta.tums.ac.ir/index.php/acta/article/download/4727/4572

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 82 84 EN Hadi Mousavi Department of Pediatrics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Salar Bakhtiyari Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. 2015 10 11 Decreased level of consciousness in neonates may result from different etiologies, including rare metabolic and hormonal disorder due to anterior pituitary insufficiency. In this case report, a five-day-old newborn boy was referred to the neonatal intensive care unit of Mustafa Khomeini hospital of Ilam, Iran. He had an open anterior fontanel with no history of prenatal and familial diseases. Clinical examination showed decreased level of consciousness so that this patient responded only to painful stimuli. Furthermore, unconsciousness, hyperbilirubinemia, and hypotonia were fully evident. Given the clinical findings and decreased level of consciousness, hormonal diagnostic tests and brain CT scan were performed for any evidence of hypopituitarism. Clinical and experimental findings were consistent with the generalized edema and pituitary insufficiency secondary to central hypothyroidism and cortisol deficiency. Based on the findings, the neonate was put on the hormonal replacement therapy and, as the result, all of the abnormal clinical symptoms disappeared. In conclusion, fatal neonatal diseases may be mistaken with unimportant clinical findings at the first examination. Therefore, comprehensive attention to all potential causes of such symptoms in the neonates should be given for early diagnosis and treatment, and to prevent any fatal and irreversible complications. https://acta.tums.ac.ir/index.php/acta/article/view/4725 https://acta.tums.ac.ir/index.php/acta/article/download/4725/4573

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 85 87 EN Zahra Hadipour Department of Medical Genetics, Sarem Cell Research Center & Hospital, Tehran, Iran. Yousef Shafeghati Department of Medical Genetics, Sarem Cell Research Center & Hospital, Tehran, Iran. AND Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Fatemeh Hadipour Department of Medical Genetics, Sarem Cell Research Center & Hospital, Tehran, Iran. 2015 10 11 The Yunis-Varón syndrome represents a rare autosomal recessive syndrome of easy recognition characterized by defective growth of the cranial bone along with complete or partial absence of the clavicles (cleidocranial dysplasia), absence of thumbs and halluces, distal aphalangia, ectodermal anomalies, growth retardation and poor outcome. The molecular genetic basis is unknown. Here, we report an 8 months old girl with Yunis-Varón syndrome, born to a consanguineously married, with normal parents. She had micrognathia, wide fontanels, prominent eyes, poor sucking, congenital heart diseases, asymmetric face, ambiguous genitalia, reduction anomaly in right hand including thumb, and hypoplastic distal phalanges of 3th fingers, and hypo plastic clavicles. She has glaucoma and lenses opacity. There is another similar case in her family. Karyotype is normal. She is the first Iranian known case of Yunis-Varón syndrome. https://acta.tums.ac.ir/index.php/acta/article/view/4723 https://acta.tums.ac.ir/index.php/acta/article/download/4723/4574

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 88 90 EN Soraya Salehgargari Department of Obstetrics and Gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Behrokh Sahebdel Department of Obstetrics and Gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ali Zare Department of Clinical & Anatomical Pathology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hassan Abolhassani Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Ectopic decidualization with gross involvement of the peritoneum is one of the rare findings in pregnant women particularly when ectopic decidualization disseminated as an asymptomatic intra-abdominal nodule. We present here a case of an ectopic decidualization in a 33-year-old pregnant woman with symptoms of irritable bowel syndrome during pregnancy. https://acta.tums.ac.ir/index.php/acta/article/view/4721 https://acta.tums.ac.ir/index.php/acta/article/download/4721/4575

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 91 92 EN Pegah Larki Research Center for Immunodeficiencies, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Shahrouz Khoshbakht Research Center for Immunodeficiencies, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Nima Rezaei Research Center for Immunodeficiencies, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. AND Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 No Abstract https://acta.tums.ac.ir/index.php/acta/article/view/4720 https://acta.tums.ac.ir/index.php/acta/article/download/4720/4576

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 1 2014 01 15 173 174 EN Mahmood Hosseinzadeh Maleki Birjand Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran. Ehsan Noori Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. Amir Adhami Department of Cardiovascular Surgery & Nephrology, Vali e Asr Hospital, Birjand University of Medical Sciences, Birjand, Iran. Seyed Alireza Javadinia Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. 2015 10 11 The number of patients with end-stage renal disease has steadily increased and improvements in hemodialysis techniques have lead to extended life expectancy. Pseudoaneurysm is a relatively rare complication of autogenous vascular access. We have reported a case in which an anastomotic pseudoaneurysm developed in a patient on hemodialysis treatment. https://acta.tums.ac.ir/index.php/acta