Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 10 2014 10 15 728 733 EN Shabnam Yazdian Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Najmeh Fahham Department of Pharmacology, Iran Pasteur Institute, Tehran, Iran. Mohammad Hossein Ghahremani Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Monireh Afzali Virtual School, Tehran University of Medical Sciences, Tehran, Iran. Narges Farsandaj Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Melody Vatankhah Department of Biology, College of Science, University of Tehran, Tehran, Iran. Seyed Nasser Ostad Department of Toxicology and Pharmacology, Toxicology and Poisoning Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 There is a great concern about the effect of propoxur, as one of the more common N-methyl carbamate pesticides, on human health due to its extensive use in agricultural and non-agricultural applications. Caco-2 cells became resistant to propoxur, and the resistance was confirmed through MTT assay. Then the cell membrane integrity and P-glycoprotein expression were measured by LDH assay and western blot analysis, respectively and compared to the parent cells.  Contrary to what was expected, the expression of P-glycoprotein in propoxur resistant cells was lower than parent cells.This study indicates that the resistance to propoxur may not be related to P-glycoprotein expression directly, since P-glycoprotein expression has decreased in these cells. https://acta.tums.ac.ir/index.php/acta/article/view/4557 https://acta.tums.ac.ir/index.php/acta/article/download/4557/4639

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 10 2014 10 15 734 739 EN Ali Mostafavi Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahmoud Solhi Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad-Reza Mohammadi Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Hamedi Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Maryam Keshavarzi Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Shahin Akhondzadeh Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Olanzapine is the frequently prescribed drug in children and adolescents with bipolar disorder, but unfortunately it has metabolic side-effects. On the other hand, in a number of melatonin studies on sleep cycle, regulation of metabolic abnormalities has been reported. Therefore, we aimed to study effects of melatonin in reducing metabolic side-effects of olanzapine in 11-17 year-old patients with bipolar disorder. Seventy-seven 11-17 year-old outpatients entered into the study after their initial diagnosis of bipolar mood disorder by a psychiatrist. After assessing inclusion and exclusion criteria, 48 patients consented to participate in the study. Of this number, 24 patients were allocated to olanzapine, lithium carbonate, and melatonin and 24 patients were allocated to olanzapine, lithium carbonate, and placebo. Young mania rating scale was performed at baseline. Before treatment initiation and at sixth and twelfth weeks after treatment, Lipid profile, Fasting Blood Sugar (FBS), Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) were measured. ANOVA with repeated measure and independent sample t-test were used for data analysis. Nineteen patients in each group completed the study and yielded data for analysis.  ANOVA with repeated measure showed that FBS and Triglyceride (TG) (especially in boys) demonstrated greater increase in the placebo group compared to the melatonin group but the differences were not statistically significant. Melatonin significantly inhibited the rise in Total Cholesterol levels compared to placebo (P=0.032). Mean SBP rose more slowly in the melatonin group (1.05mmHg) compared to placebo (6.36 mmHg) (P=0.023). The trends in DBP did not show any significant pattern. Administration of melatonin along with olanzapine and lithium carbonate could significantly inhibit the rise in cholesterol level and SBP compared to placebo. The effect of melatonin on TG was more obvious in boys. Melatonin was more effective in prevention of SBP rise. https://acta.tums.ac.ir/index.php/acta/article/view/4556 https://acta.tums.ac.ir/index.php/acta/article/download/4556/4640

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 10 2014 10 15 740 747 EN Zohreh Heidari Digestive Oncology Research Center Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Kiana Shahzamani Department of Biology, Faculty of Sciences, Lorestan University, Khorram-abad, Iran. Reza Ghanbari Digestive Oncology Research Center Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Arash Tahamsebifar Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran. 2015 10 11 Hepatitis C Virus is one of the main reasons for chronic liver disease and hepatocellular carcinoma. Combination therapy with Interferon (peg-IFN-α) and Ribavirin (RBV) clear the virus more likely than the others. Different factors like virus and host characteristics influence on response to treatment. The most important viral factors include virus genotype and viral load; host factors like genetic, gender, race, age, weight and liver enzymes are also important. Previous studies have shown that single nucleotide polymorphisms (SNPs) in IFNR genes can regulate and influence on treatment with IFN. The purpose of this study is to investigate the association between SNPs in IFN-α receptor (IFNAR1 & IFNAR2) genes among subjects affected with chronic hepatitis C, who have treated with IFN and RBV, and also relationship between HCV genotypes and response to combination antiviral therapy. Peripheral blood mononuclear cells (PBMCs) were taken from whole blood of 61 patients affected with chronic hepatitis C who were treated with IFN and Ribavirin. Then, DNA was extracted from PBMCs and quality of DNA was assessed with Nanodrop finally two SNPs [Ex4-30G>C] and [Ivs1-4640 G>A] of IFN receptor genes (IFNAR1 and IFNAR2) were measured by TaqMan Real-Time PCR in ABi Prism 7900 system. Also to confirm the response rate to therapy, RNA was extracted then RT PCR was performed and final product was studied with gel electrophoresis and UV spectroscopy. Statistical analysis was performed using SPSS version 18.0 for Windows. The analysis of results from TaqMan SNP Genotyping has been shown that two SNPs (Ex4-30G>C and Ivs1-4640 G>A) of IFNAR1 and IFNAR2 didn't show any relationship with response to combined therapy in subjects affected with chronic hepatitis C who have treated with peg-IFN-α and Ribavirin. 61 patients complete the treatment period. 54 patients (%88/5) of them responded to treatment and 7 patients (%11/5) did not. Research and data analysis have shown that there is no significant relationship between sex (P=0 /7) and age (P=0 /2). But there is a relationship between genotype-3a and response to combined therapy of IFN-α and RBV (0/02). Studies have shown that gene polymorphisms in IVSS1-22G location of IFNAR1 gene had a relationship with IFN treatment response. But current study has shown that there is no significant relationship between two SNPs Ex4-30G>C and Ivs1-4640 G>A and response to IFN therapy. In continue we suggest that it would be better to use this technique to evaluate other SNPs in IFN genes. https://acta.tums.ac.ir/index.php/acta/article/view/4555 https://acta.tums.ac.ir/index.php/acta/article/download/4555/4641

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 10 2014 10 15 748 751 EN Amira Hamzaoui Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia. Fatima Jaziri Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia. Thouraya Ben Salem Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia. Fatma Said Imed Ben Ghorbel Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia. Mounir Lamloum Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia. Monia Smiti Khanfir Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia. Habib Houman Mohamed Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia. 2015 10 11 Behcet's disease (BD) is a multisystemic inflammatory disease that occurs most often between the second and fourth decade of life. Patients have been reported during the first months of life and after 70 years. Our objective was to determine the clinical, paraclinical and genetic characteristics of BD in patients aged < 20 and > 40 years. We conducted a comparative retrospective study including patients with BD (Criteria of International Study Group on BD). Patients were divided into two groups: those < 20 years (Group one) and those > 40 years (Group two). The clinical, paraclinical and genetic (HLA) characteristics were determined and compared in the two groups. The data were compiled and analyzed using SPSS 11.0. Thirty totals of 430 patients were included. Group one included 81 patients (55 men and 26 women). Group two included 68 patients (45 men and 23 women). Cutaneous involvement (88.9 versus 76.5%; P=0.043), pseudofolliculitis (84 versus 64.5%; P=0.004) and vena cava thrombosis (11.11 vs 0%; P=0.004) were significantly more frequent in group one while joint involvements were more common in group two (57.4 versus 40.7%; P= 0.043). The frequency of erythema nodosum as well as ocular, vascular and neurological disorders was comparable between the two groups. Few studies in the literature have compared the clinical, paraclinical and genetic characteristics of BD, who had first symptom onset after 40 years of age. Late-onset BD, usually, affects both genders equally. According to present results, the frequency of severe organ involvement is equal regardless of age, except for vena cava thrombosis. https://acta.tums.ac.ir/index.php/acta/article/view/4554 https://acta.tums.ac.ir/index.php/acta/article/download/4554/4642

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 10 2014 10 15 752 756 EN Setila Dalili Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, Faculty of Medicine, Guilan University of Medical Sciences, Guilan, Iran. Seyed Mahmood Rezvani Health Center, Guilan University of Medical Sciences, Guilan, Iran. Hossein Dalili Department of Pediatrics, Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran. Zahra Mohtasham Amiri Department of Social Medicine, Faculty of Medicine, Guilan University of Medical Sciences, Guilan, Iran. Hamid Mohammadi Department of Pediatrics, Faculty of Medicine, Shiraz University of Medical Sciences, Fars, Iran. Sahar Abrisham Kesh Health Center, Guilan University of Medical Sciences, Guilan, Iran. Mohammad Hassan Novin Health Center, Guilan University of Medical Sciences, Guilan, Iran. Abdolreza Medghalchi Eye Research Center, Amiralmomenin Hospital, Faculty of Medicine, Guilan University of Medical Sciences, Guilan , Iran. Hajar Gholamnezhad Health Center, Guilan University of Medical Sciences, Guilan, Iran. 2015 10 11 One of the most preventable causes of mental and growth retardation is congenital hypothyroidism (CH). This study tries to investigate growth and mental outcome of patients with CH. Since November 2006 and November 2007 in Guilan province, north of Iran, all neonates who were diagnosed with CH, evaluated for etiology of CH by laboratory follow up, thyroid sonography or scan. Growth and development of patients with CH were compared with healthy children in same age, geographical area, social and economical classes in four years old. Demographic characteristics including height, weight, and head circumference at birth, follow up time (four years old) and IQ (Good enough test) were recorded in questionnaires. Among 28904 screened neonates, 37 patients with CH were diagnosed. Incidence of CH was 1:781 in live births, 20 (54%) in female neonates and 17 (46%) in male neonates. The incidences of permanent and transient hypothyroidism were 43.2% (16 cases) and 56. 8% (21 cases) respectively. The incidence of permanent and transient hypothyroidism were 16 (43.2%) and 21 (56, 8%), respectively. In permanent CH, 11 cases (%.68.2) had dyshormonogenesis and 5 cases (%.31.2) had thyroid dysgenesis. Significant statistical difference was only in family history of thyroid disease (34, 3% Positive family history in CH vs. 13.2% in control group, P-value 0.03). All other demographic characteristics and IQ had no statistical difference. Patients with CH diagnosed through neonatal screening and treated had normal growth as general population that indicates effective screening program and treatment in this area (3.2%). https://acta.tums.ac.ir/index.php/acta/article/view/4553 https://acta.tums.ac.ir/index.php/acta/article/download/4553/4643

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 10 2014 10 15 757 763 EN Nahid Dehghan Nayeri Department of Nursing, Nursing and Midwifery Care Research Center, Tehran University of Medical Sciences, Tehran, Iran. Abbas Hooshmand Bahabadi Department of Nursing, Tehran University of Medical Sciences, Tehran, Iran. Anoshirvan Kazemnejad Department of Biostatistics, Faculty of Public Health, Tarbiat Modares University, Tehran, Iran. 2015 10 11 One of the main objectives of quantitative researches is assessment of models developed by qualitative studies. Models validation through their testing implies that the designed model is representative of the existed facts. Hence, this study was conducted to assess the clinical nurses' productivity model presented for Iranian nurses' productivity. The sample of the study consisted of 360 nurses of Tehran University of Medical Sciences. The research tool was a questionnaire for measuring the components of clinical nurses' productivity. After completing all steps of instrument psychometric and getting answers from the participants, the factors introduced in the questionnaire were named and then Lisrel Path Analysis tests were performed to analyze the components of the model. The results of the model test revealed there is an internal relationship among different anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This study was designed to assess Pel memory enhancing effects on the a rat Amyloid Beta25-35 (Aβ) intrahippocampal microinjections model of AD in the passive avoidance task performance paradigm and further evaluate the potential estrogen receptor role on the memory-evoking compound. Equally divided rats were assigned to 5 groups of sham, Aβ intrahippocampal microinjected, Pel pretreated (10 mg/kg; P.O), α estrogen antagonist intra-cerebrovascular (i.c.v.) microinjected, and β estrogen antagonist (i.c.v) microinjected animals. Intrahippocampal microinjections of Aβ were adopted to provoke AD model. Passive avoidance task test was also used to assess memory performance. Pel pretreatment prior to Aβ microinjections significantly improved step-through latency (P<0.001) in passive avoidance test. In α and β estrogen, antagonists received animals, passive avoidance task performance was not statistically changed (P=0.11 & P=0.41 respectively) compared to Pel pretreated and sham animals. Our results depicted that Pel improves Aβ induced memory dysfunction in passive avoidance test performance through estrogen receptor independently related pathways. https://acta.tums.ac.ir/index.php/acta/article/view/4980 https://acta.tums.ac.ir/index.php/acta/article/download/4980/4776

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 4 2016 05 10 251 255 EN Mohammad Reza Talebi-Ardakani Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Maryam Torshabi Department of Dental Biomaterials, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Elahe Karami Department of Periodontics, School of Dentistry, Yazd University of Medical Sciences, Yazd, Iran. Elham Arbabi School of Dentistry, International Branch, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zeinab Rezaei Esfahrood Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2015 10 26 2015 12 15 The ultimate goal of the periodontal treatments is a regeneration of periodontium. Recently, laser irradiations are commonly used to improve wound repair. Because of many controversies about the effects of laser on soft tissue regeneration, more in vitro studies are still needed. The aim of the present in vitro study was to compare the effects of different doses of Er:YAG (erbium-doped:yttrium, aluminum, garnet) and Er, Cr:YSGG (erbium, chromium-doped: yttrium, scandium, gallium, garnet) laser treatment on human gingival fibroblasts (HGF) proliferation. In this randomized single-blind controlled in vitro trial, HGF cells were irradiated using Er:YAG and Er, Cr:YSGG laser for 10 and 30 seconds or remained unexposed as a control group. After a culture period of 24 and 48 hours, HGF cell proliferation was evaluated by MTT assay. The data were subjected to one-sided analysis of variance and Tukey multiple comparison tests. Our results showed Er:YAG application for 10 and 30 seconds as well as Er, Cr:YSGG irradiation for 10 and 30 seconds induced statistically significant (P<0.05) proliferation of HGF cells as compared with the control at 24 hours up to 18.39%, 26.22%, 21.21%, and 17.06% respectively. In 48 hour incubations, Er:YAG and Er, Cr:YSGG irradiation for 10 and 30 seconds significantly increased cellular proliferation up to 22.9%, 32.24%, 30.52% and 30.02% respectively (P<0.05). This study demonstrates that Er:YAG and Er, Cr:YSGG laser significantly increased HGF cell proliferation compared to the control specimens. This higher proliferation can lead to increased wound repair in clinical conditions. https://acta.tums.ac.ir/index.php/acta/article/view/5065 https://acta.tums.ac.ir/index.php/acta/article/download/5065/4777

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 4 2016 05 10 256 260 EN Kobra Farahani Department of Basic Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran. Mehrdad Hashemi Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. 2015 10 20 2015 12 26 Ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. This brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. The aim of this study is investigating the effect of hydroalcoholic extract of Cyperus rotundus L. on the expression of the Bcl-x1 antiapoptotic gene in rats’ hippocampus tissue following global ischemic-reperfusion injury. In the present study, attempts were made to investigate the effect of hydroalcoholic extract of Cyprus rotundus L. on the expression of the Bcl-x1 antiapoptotic gene in rats’ hippocampus tissue following global ischemic-reperfusion. To this end, eighteen male Wistar rats (250-300 g body wt) were used in this study. The animals were divided into three classes, each including 6 rats, I: Control class without ischemia-reperfusion, II: Ischemia-reperfusion class that was subjected to all surgical procedures, III: extract injection class that received Cyperus rotundus L. after ischemia. Seventy two hours after ischemia-reperfusion, the hippocampus was derived for studying the changes in bcl-xl gene expression. Q real-time PCR was employed for the detection of bcl-xl gene expression in ischemia and extract groups, and then their results were compared with normal samples. The results showed the generations of 0.6233, 0.23, and 0.9933 for control, ischemia, and ischemic extract groups, respectively. Moreover, it was found that the bcl-xl gene expression declined in ischemia group as compared to the extract group. A significant difference in the bcl-xl gene expression was observed in ischemia group when compared with the groups which had both injection and ischemia. These findings are consistent with anti-apoptotic properties of the bcl-xl gene. It can be concluded that this method creates a powerful tool for the investigators to study brain ischemia and the responses to the treatment which are caused by the injection of Cyprus rotundus L. https://acta.tums.ac.ir/index.php/acta/article/view/5018 https://acta.tums.ac.ir/index.php/acta/article/download/5018/4778

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 4 2016 05 10 261 269 EN Seyed Hesameddin Abbasi Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Seyed Ebrahim Kassaian Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Saeed Sadeghian Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Abbasali Karimi Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Soheil Saadat Sina Trauma Research Center, Tehran University of Medical Sciences, Tehran, Iran. Flora Peyvandi Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Milan, Italy. AND Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. Arash Jalali Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Tahereh Davarpasand Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Shahin Akhondzadeh Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran. Nazila Shahmansouri Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Ali Boroumand Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Masoumeh Lotfi-Tokaldany Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Maryam Amiri Abchouyeh Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Farah Ayatollahzade Isfahani Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Frits Rosendaal Department of Clinical Epidemiology and Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands. 2015 10 17 2015 10 28 Anxiety may negatively affect the course of coronary artery disease (CAD). The aim of this study was to assess which factors are associated with anxiety in young adults with CAD. A cohort of individuals with premature coronary artery disease was formed between 2004-2011, as the Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (THC-PAC) study. Patients (men≤45-year-old, and women≤55-year-old) were visited between March 2013 and February 2014. All participants were examined, and their demographic, clinical, and laboratory data were collected. Then, all participants filled in the Beck Anxiety Inventory. Logistic regression models were used to identifying factors related to anxiety in both sexes. During the study, 708 patients (mean [SD] age: 45.3 [5.8] y, men:48.2%) were visited. Anxiety was present in 53.0% of participants (66.0% of women and 39.0% of men). The logistic regressions model showed that the associated factors for anxiety in men were opium usage (OR=1.89, 95% CI: 1.09-3.27), positive family history (OR=1.49, 95% CI:0.94-2.35), and creatinine serum level (OR=1.17, 95% CI:1.05-1.303); and in women were major adverse cardiac events (MACE) during follow-up (OR=2.30, 95% CI:1.25-4.23), hypertension (OR=1.71, 95% CI:1.07-2.73) and the duration of CAD (OR=0.99, 95% CI:0.98-1.00). In premature CAD patients, the determinants of anxiety seem to be different in each sex. Opium usage, positive family history of CAD, and creatinine serum levels in men, and MACE, hypertension, and duration of CAD in women appear the relevant factors in this regard. https://acta.tums.ac.ir/index.php/acta/article/view/4984 https://acta.tums.ac.ir/index.php/acta/article/download/4984/4784

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 4 2016 05 10 270 275 EN Shahin Koomanaee Pediatrics Growth Disorders Research Center, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Manijeh Tabrizi Pediatrics Growth Disorders Research Center, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Novin Naderi Pediatrics Growth Disorders Research Center, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Afagh Hassanzadeh Rad Pediatrics Growth Disorders Research Center, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Kobra Boloky Moghaddam Pediatrics Growth Disorders Research Center, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Setila Dalili Pediatrics Growth Disorders Research Center, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. 2015 10 10 2015 11 04 The aim of this study was to investigate the correlation between each parent’s Body Mass Index (BMI) and maternal age with weight status of children. This was an analytic cross-sectional study which was conducted on 12-year-old students from different areas in Rasht, north part of Iran. The checklist included demographic characteristics such as age, maternal age during childbirth, student and maternal height and weight, child rank. Data were analyzed by Pearson correlation analysis, paired t-test and ANOVA test and chi-square in SPSS software 19.0. A P-value less than 0.05 were considered statistically significant. A total of 200 adolescents participated in this study consisted of 106 (53%) boys. Results showed a significant correlation between students’ BMI and parental BMI and father’s weight. Also, there was a significant correlation between students’ weight with parental BMI and father’s weight, and birth rankIn conclusion, the role of the family in changing nutritional habits of children must be considered because through parental education and changing their perceptions we can prevent obesity. https://acta.tums.ac.ir/index.php/acta/article/view/4310 https://acta.tums.ac.ir/index.php/acta/article/download/4310/4779

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 4 2016 05 10 276 279 EN Gholam Hossein Fallahi Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Sahar Latifi Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Maryam Mahmoudi Department of Cellular and Molecular Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. AND Dietitians and Nutrition Experts Team (DiNET), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Davood Kushki Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Taghi Haghhi Ashtiani Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Afsaneh Morteza Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Nima Rezaei Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. 2015 12 15 2016 03 04 Cystic fibrosis (CF) is an autosomal recessive disease, which affects many organs as it impairs chloride channel. This study was performed to evaluate growth status and its relationship with some laboratory indices such as Cholesterol (chol), Triglyceride (TG), albumin and total protein in children with CF referred to pediatrics center. This study was designed as a cross-sectional study in one year section. Demographic features were compared with standard percentiles curves. Chol, TG, albumin, total protein, prothrombin time, and hemoglobin were measured. Stool exams were also performed. A questionnaire was designed to obtain a history of the first presentation of disease, birth weight, type of labor and parent relativity. In 52% of patients, failure to thrive (FTT) was the first presentation. Steatorrhea and respiratory infections were the first presentations, which were seen in 13.7% and 33% of the cases, respectively. The weight of 88% of patients was below the 15th percentile while 82% had a height percentile below 15th. Head circumference in 53% of patients was below the 15th percentile. There was a significant association between weight percentile and serum albumin and total protein (P=0.03 and P=0.007, respectively). There was also a significant relationship between height percentile and serum albumin and total protein (P<0.001 and P<0.000, respectively). The relationships between head circumference and serum albumin and total protein were a