<?xml version="1.0"?>
<Articles JournalTitle="Acta Medica Iranica">
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Universal Scientific Education and Research Network (USERN): Twinkling Stars Unite to Make the World Glow</title>
    <FirstPage>1</FirstPage>
    <LastPage>3</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Nima</FirstName>
        <LastName>Rezaei</LastName>
        <affiliation locale="en_US">Universal Scientific Education and Research Network (USERN), Tehran, Iran. AND Research Center for Immunodeficiencies, Children&#x2019;s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2018</Year>
        <Month>01</Month>
        <Day>14</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2018</Year>
        <Month>01</Month>
        <Day>17</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">No Abstract</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6958</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6958/5036</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Evaluation of Chronic Losartan Treatment Effect on Cardiac Chronotropic Dysfunction in Biliary Cirrhotic Rats</title>
    <FirstPage>4</FirstPage>
    <LastPage>13</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Farahnaz</FirstName>
        <LastName>Jazaeri</LastName>
        <affiliation locale="en_US">Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Razieh</FirstName>
        <LastName>Afsharmoghaddam</LastName>
        <affiliation locale="en_US">Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Alireza</FirstName>
        <LastName>Abdollahi</LastName>
        <affiliation locale="en_US">Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Giti</FirstName>
        <LastName>Ghamami</LastName>
        <affiliation locale="en_US">Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Ahmad Reza</FirstName>
        <LastName>Dehpour</LastName>
        <affiliation locale="en_US">Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2017</Year>
        <Month>04</Month>
        <Day>11</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>10</Month>
        <Day>21</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">Cirrhosis is associated with cardiac chronotropic and inotropic dysfunction which is known as cirrhotic cardiomyopathy. Cardiac responsiveness to adrenergic stimulation is impaired in cirrhosis. Moreover, there is vagal nerve dysfunction which is related to neuromodulatory dysfunction of the angiotensin II in the cirrhosis. This study was aimed to explore the hypothesis that administration of Losartan-angiotensin II receptor antagonist increases cardiac chronotropic response to isoproterenol in cirrhotic rats; and if so, whether this is associated with altered cardiac TGF-&#x3B2; receptor expression. Cirrhosis was induced by surgical ligation of the bile duct (BDL) in male Wister rats. Half of the BDL-group and control group were treated with losartan for four weeks. Four weeks after bile duct ligation or sham surgery the atria were isolated and spontaneously beating rate and chronotropic responsiveness to &#x3B2;-adrenergic stimulation was assessed using standard organ bath. The pathological assessment was done on the atria. Moreover, the expression of TGF-&#x3B2; has assessed the atria using quantitative RT-PCR. Bile duct ligation could induce a significant hypo-responsiveness to adrenergic stimulation. In cirrhotic rats, the chronotropic responses increased after chronic treatment with losartan, but it was not significant. The pathological study showed that losartan could not decrease fibrosis in atria in losartan treated cirrhotic group. TGF-&#x3B2; expression is markedly increased in cirrhotic rats which are significantly decreased in atria following administration of losartan. These results might be considered as angiotensin II role in cirrhotic cardiomyopathy, but further studies are required to elaborate the mechanism as well as the possible advantage of losartan. We conclude that cirrhosis in rats is associated with altered expression of TGF-&#x3B2; in the atrium which losartan can ameliorate it.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6351</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6351/5037</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">A Case of Kleine-Levin Syndrome: Diagnostic and Therapeutic Challenge</title>
    <FirstPage>62</FirstPage>
    <LastPage>66</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Marino</FirstName>
        <LastName>Mar&#x10D;i&#x107;</LastName>
        <affiliation locale="en_US">Department of Neurology, Clinical Hospital Center Split, Split, Croatia.</affiliation>
      </Author>
      <Author>
        <FirstName>Ljiljana</FirstName>
        <LastName>Mar&#x10D;i&#x107;</LastName>
        <affiliation locale="en_US">Department of Radiology, Clinical Hospital Center Split, Split, Croatia.</affiliation>
      </Author>
      <Author>
        <FirstName>Marina</FirstName>
        <LastName>Titli&#x107;</LastName>
        <affiliation locale="en_US">Department of Neurology, Clinical Hospital Center Split, Split, Croatia.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2015</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2016</Year>
        <Month>10</Month>
        <Day>10</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hyper sexuality. Etiology is unknown, and there is no specific clinical or imaging test for this syndrome even though the illness has well-defined clinical features. Also, there is no effective treatment for KLS. KLS is self-limited, so the prognosis for these patients is not so bad. This study presents our case report and comprehensive workout that led to diagnosis which is primarily clinical. Our patient is a 20-year-old man referred to our clinic because of sleeping problems. At the age of 14, he presented with complaints of the excessive duration of sleep, increased appetite, excessive daytime sleepiness, loss of interest in social activities during attendance of high school and hallucinations. The excessive diagnostic procedure does not find pathological. Kleine-Levin syndrome (KLS) is a rare sleep disorder of unknown etiology which diagnosis is clinical and diagnostic workup is mainly to exclude other similar conditions. There is no specific therapy, but the disease is self-limited and with good prognosis.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/5227</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/5227/5044</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice</title>
    <FirstPage>14</FirstPage>
    <LastPage>20</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Sattar</FirstName>
        <LastName>Ostadhadi</LastName>
        <affiliation locale="en_US">Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Abouzar</FirstName>
        <LastName>Moradi</LastName>
        <affiliation locale="en_US">Department of Periodontics, School of Dentistry, Alborz University of Medical Sciences, Alborz, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Samira</FirstName>
        <LastName>Zolfaghari</LastName>
        <affiliation locale="en_US">Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Vahid</FirstName>
        <LastName>Nikoui</LastName>
        <affiliation locale="en_US">Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Ahmad Reza</FirstName>
        <LastName>Dehpour</LastName>
        <affiliation locale="en_US">Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2017</Year>
        <Month>03</Month>
        <Day>01</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>12</Month>
        <Day>12</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies. In the present experiment, the possible effect of cromakalim on the convulsion and death induced by OPs and carbamates was studied in mice. Dichlorvos (an OP, 50 mg/kg) and physostigmine (a carbamate, 2 mg/kg) were used to induce seizure in animals. Cromakalim at doses of 0.1, 10, and 30 &#xB5;g/kg was injected 30 min before dichlorvos and physostigmine, and 5 min before glibenclamide (a potassium channel blocker, 1 mg/kg) administration. All injections were performed intraperitoneally. After drugs administration, the onset of convulsion, death, the severity of seizure, and rate of mortality were investigated. Results revealed that both dichlorvos and physostigmine induced seizure activity and lethality in 100% of the animals. Cromakalim at doses of 0.1, 10, and 30 &#xB5;g/kg significantly increased the latency of both seizure and death (P&lt;0.05). Also, cromakalim decreased the mortality rate induced by dichlorvos and physostigmine (P&lt;0.05). On the other hand, glibenclamide blocked all aspects of the anticonvulsant effect of cromakalim (P&lt;0.05). This study revealed for the first time that cromakalim (a KATP channel opener) diminishes the seizure and death induced by dichlorvos and physostigmine in mice, and introduces a new aspect to manage the patients who suffer from OPs/carbamates-induced seizure.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6272</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6272/5038</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">A Road to the Heart From Uterine Closet: A Case Report</title>
    <FirstPage>67</FirstPage>
    <LastPage>70</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Aghygh</FirstName>
        <LastName>Heidari</LastName>
        <affiliation locale="en_US">Department of Anesthesiology, Kermanshah University of Sciences, Imam Ali Hospital, Kermanshah, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Samsam</FirstName>
        <LastName>Dabiri</LastName>
        <affiliation locale="en_US">Department of Cardiac Surgery, Kermanshah University of Sciences, Imam Ali Hospital, Kermanshah, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Feridoun</FirstName>
        <LastName>Sabzi</LastName>
        <affiliation locale="en_US">Department of Cardiac Surgery, Kermanshah University of Sciences, Imam Ali Hospital, Kermanshah, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2016</Year>
        <Month>09</Month>
        <Day>29</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>05</Month>
        <Day>02</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">Angiosarcomas of the uterine is a malignant and poor prognostic tumor and can either be a primary sarcoma or arising secondary to radiotherapy of a more complex tumor. Primary uterine angiosarcomas are exceptional and probably arise from embryonic vascular remnants, teratoma or from the rich uterine vasculature. We reported a rare case of primary angiosarcoma of uterine that at the time of diagnosis presented with sign and symptom of local and distant metastasis. The patient presented with dyspnea, chest pain, and history of vaginal bleeding and pelvic pain. The physical exam revealed pallor, prominent jugular pulse pressure, a palpable fixed mass in the pelvic however vaginal exam was unremarkable. Transthoracic echocardiography (TTE) revealed massive pericardial effusion and also a large mass in the right atrium. The abdominal ultrasound showed echogenic and poor echogenic segments in uterine mass combined with central necrosis. The patient underwent total hysterectomy and Bilateral salpingo-oophorectomy followed by radiotherapy and adjuvant chemotherapy. The patient underwent open heart surgery with resection of cardiac mass and further received a four cycle of radiotherapy (50 MG) to the mediastinum. The further follow-up (6 month) revealed no recurrence of tumor in a mediastinum. However, patient died from metastasis to the liver and its hepatic failure sequels.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/5912</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/5912/5045</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Promoter Hypermethylation of the Eyes Absent 4 Gene is a Tumor-Specific Epigenetic Biomarker in Iranian Colorectal Cancer Patients</title>
    <FirstPage>21</FirstPage>
    <LastPage>27</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Matineh</FirstName>
        <LastName>Barati Bagerabad</LastName>
        <affiliation locale="en_US">Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Biology, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Sahar</FirstName>
        <LastName>Tavakolian</LastName>
        <affiliation locale="en_US">Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Biology, University of Sistan and Balouchestan, Zahedan, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mohammad Reza</FirstName>
        <LastName>Abbaszadegan</LastName>
        <affiliation locale="en_US">Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mohammad Amin</FirstName>
        <LastName>Kerachian</LastName>
        <affiliation locale="en_US">Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Cancer Genetics Research Unit, Reza Radiotherapy and Oncology Center, Mashhad, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2017</Year>
        <Month>03</Month>
        <Day>16</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>12</Month>
        <Day>12</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">The aim of this study was to investigate whether hypermethylation of Eyes Absent 4 (EYA4) is also implicated in Iranian Colorectal Cancer (CRC) patients or not. From fresh frozen tissues, samples from 38 paired (cancer and normal) CRC tissue specimens were used in this study, the DNA was isolated, sodium bisulfite treated and analyzed by methylation-specific polymerase (MSP) chain reaction using primers specific for unmethylated or methylated promoter sequences of the EYA4 gene. We also analyzed EYA4 mRNA expression using real time RT-PCR. Demographic characteristics of these patients including age, sex, tumor grade, location, stage, and TNM classification were evaluated and the relationship between methylation status of the gene and clinicopathological features was analyzed. Current study indicated that EYA4 promoter hypermethylation has a sensitivity of 81.57% and specificity of 78.94%. Findings showed lower expression of EYA-4 in methylated samples in comparison with its normal adjacent tissue, although it was not significant (P&gt;0.05). No significant associations were observed between EYA4 hypermethylation and the clinicopathological characteristics. Although the clinical patient outcome of our 38 CRC patients was not associated with EYA4 promoter hypermethylation, the high frequency of this methylation and its high sensitivity and specificity to neoplastic cells may qualify EYA4 promoter methylation as a potential candidate screening marker in Iranian population and may help to improve early detection of CRC.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6312</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6312/5039</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">&#x201C;Eye of the Tiger&#x201D; in a Non-Responsive Neuropsychiatric Patient: A Case Report</title>
    <FirstPage>71</FirstPage>
    <LastPage>73</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Milad</FirstName>
        <LastName>Hosseinialhashemi</LastName>
        <affiliation locale="en_US">Student's Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Babak</FirstName>
        <LastName>Daneshfard</LastName>
        <affiliation locale="en_US">Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. AND Essence of Parsiyan Wisdom Institute, Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran. AND Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Atefe</FirstName>
        <LastName>Hashemi</LastName>
        <affiliation locale="en_US">Student's Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2016</Year>
        <Month>11</Month>
        <Day>07</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>04</Month>
        <Day>16</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">Hallervorden-Spatz syndrome is a rare neurodegenerative disorder with hereditary properties. It usually occurs in young adolescents with extrapyramidal symptoms besides disturbed mental function. In this study, we present a 23-year-old neuropsychiatric patient who primarily misdiagnosed to have conversion disorder. She had 5-year history of progressive dysarthria and generalized abnormal movements. After detecting the pathognomonic sign of &#x201C;eye of the tiger&#x201D; diagnosis was confirmed. The patient was discharged. She had satisfactory condition in her follow-up. Such a rare syndrome should be considered in patients with similar presentation, and upon the diagnosis, PKAN2 gene study should be done to detect possible new mutations.
&#xD;
&#xD;

&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6001</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6001/5046</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>05</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Wharton's Jelly Derived-Mesenchymal Stem Cells: Isolation and Characterization</title>
    <FirstPage>28</FirstPage>
    <LastPage>33</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Hossein</FirstName>
        <LastName>Ranjbaran</LastNhran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>5</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>05</Month>
        <Day>20</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Impact of Prolonged Versus OCP Plus Long Protocol on IVF-ET Outcomes in Patients With Grade III-IV Endometriosis: A Randomized Clinical Trial</title>
    <FirstPage>308</FirstPage>
    <LastPage>313</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Ladan</FirstName>
        <LastName>Kashani</LastName>
        <affiliation locale="en_US">Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mahbobeh</FirstName>
        <LastName>Mohamadi</LastName>
        <affiliation locale="en_US">Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Bentol-Hoda</FirstName>
        <LastName>Fattah-Ravandi</LastName>
        <affiliation locale="en_US">Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Atefeh</FirstName>
        <LastName>Zeinoddini</LastName>
        <affiliation locale="en_US">Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2017</Year>
        <Month>11</Month>
        <Day>29</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2018</Year>
        <Month>02</Month>
        <Day>07</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">The purpose of the current study was to investigate the impact of a 2-months implementation of GnRH-agonist (prolonged) versus the OCP+long protocol before in-vitro fertilization-embryo transfer (IVF-ET) on IVF outcomes in infertile patients with Grade III-IV endometriosis. A total of 70 infertile patients with endometriosis participated in this randomized clinical trial and randomly received either the prolonged GnRH-agonist protocol (38 patients) as control or the OCP+long protocol (32 patients) as the case group. This was followed by standard controlled ovarian hyperstimulation (COH) in all subjects. The fertilization rate, the implantation rate, and the clinical pregnancy rate were measured and compared between the two groups. A statistically significant trend toward better embryo quality was observed in the control group (P=0.01). In addition, clinical pregnancy rate, implantation rate and fertilization rate did not differ significantly between two groups (P=0.43, P=0.54, P=0.1 respectively). GnRH agonist treatment for 2 months before ART in women with high-grade endometriosis was associated with better embryo quality compared to three weeks of treatment with OCP. OCP before assisted reproductive technology (ART) was as effective as GnRH agonist treatment regarding clinical pregnancy and implantation rates in infertile patients with severe endometriosis.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6867</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6867/5089</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>5</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>05</Month>
        <Day>20</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">An Acute Thrombus Formation in the Left Coronary Artery of an Atypical Kawasaki Patient</title>
    <FirstPage>351</FirstPage>
    <LastPage>354</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Mohammad Mehdi</FirstName>
        <LastName>Bagheri</LastName>
        <affiliation locale="en_US">Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. AND Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Shokouh</FirstName>
        <LastName>Arjmand</LastName>
        <affiliation locale="en_US">Kerman Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mohammad Hossein</FirstName>
        <LastName>Torabinejad</LastName>
        <affiliation locale="en_US">Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mina</FirstName>
        <LastName>Behzadi</LastName>
        <affiliation locale="en_US">Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2016</Year>
        <Month>12</Month>
        <Day>24</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>03</Month>
        <Day>30</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">Kawasaki disease (KD) is a self-limited syndrome with serious heart complications, mostly seen in children of age 5-month to 4-year-old. KD needs to be diagnosed soon to start IVIG within 10 days of starting symptoms to lower heart complications to 5 folds. Our case, a 2-year-old boy presented with prolonged fever and pharyngeal erythema. In early evaluation, erythrocyte sedimentation rate (ESR) was elevated, and after that, Color Doppler echocardiography with suspicion for KD was performed and showed aneurysm and thrombosis formation in the left coronary artery (LCA). Hence, intravenous immunoglobulin (IVIG) was started for the patient concurrent with daily check of troponin I level. In this case report, we present remarkable echocardiographic findings of a patient with the delay in diagnosis of KD demonstrating an aneurysm and acute thrombus formation in LCA.&#xA0;
&#xD;
&#xD;

&#xA0;</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6086</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6086/5102</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>5</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>05</Month>
        <Day>20</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Analysis and Description of Suicidal Burns Admitted to Al-Fayhaa General Hospital in Basra, Iraq</title>
    <FirstPage>314</FirstPage>
    <LastPage>319</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Mustafa</FirstName>
        <LastName>Al-Shamsi</LastName>
        <affiliation locale="en_US">Department of Public Health, Iraqi Ministry of Health, Basra, Iraq.</affiliation>
      </Author>
      <Author>
        <FirstName>Nasih</FirstName>
        <LastName>Othman</LastName>
        <affiliation locale="en_US">Kurdistan Institution for Strategic Studies and Scientific Research, Sulaimaniyah, Iraq.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2017</Year>
        <Month>10</Month>
        <Day>27</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>12</Month>
        <Day>19</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">Suicide by self-burning remains a common method of suicide amongst women in Iraq and some neighboring countries. This study aimed to describe the problem of self-burning in Basra province and investigate the associated factors. A prospective study was undertaken between October 2016 and May 2017 in Al-Fayhaa Burn Center. Data were collected from all patients admitted to the center for a self-inflicted burn. Sociodemographic information and cause of suicide were obtained using an interviewer-administered questionnaire, and clinical data were transcribed from hospital records. There were 62 cases (females 74%, males 26%) of self-burning during the 6 months data collection accounting for 22% of all burn admission. The age ranged from 9-56 years (mean 25.3, SD 10.8 year). The vast majority had no or only basic education (92%), 55% were married, 60% were from outside Basra city and 53% considered themselves from a poor socioeconomic background. The incident mostly occurred at home (84%) while the person was alone (91%) using kerosene as the burning material (82%). The total burn surface area ranged from 20-100% with a median of 80% (IQR 60-95). The median hospital stay was 5 days (IQR 1-12 days). In-hospital mortality rate was 72.6%. Suicide by self-burning seems not to be uncommon in Basra and require more attention from public health and social services. More research is required to provide a better estimation of the problem and in-depth understanding of the factors that contribute to the problem.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6804</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6804/5090</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>5</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>05</Month>
        <Day>20</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">The Distribution of Corneal Thickness in Rural Population</title>
    <FirstPage>320</FirstPage>
    <LastPage>328</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Hassan</FirstName>
        <LastName>Hashemi</LastName>
        <affiliation locale="en_US">Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Abbasali</FirstName>
        <LastName>Yekta</LastName>
        <affiliation locale="en_US">Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mohammad</FirstName>
        <LastName>Saatchi</LastName>
        <affiliation locale="en_US">Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Raheleh</FirstName>
        <LastName>Moravej</LastName>
        <affiliation locale="en_US">Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mohamadreza</FirstName>
        <LastName>Aghamirsalim</LastName>
        <affiliation locale="en_US">Eye Research Center, Rassoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mehdi</FirstName>
        <LastName>Khabazkhoob</LastName>
        <affiliation locale="en_US">Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2017</Year>
        <Month>09</Month>
        <Day>02</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>12</Month>
        <Day>19</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">To determine the distribution of corneal thickness and its associated factors in the over 5-year-old population in the north and south rural areas in Iran. In this study, samples were selected using multi-stage cluster sampling. After vision and refraction tests and the slit lamp exam, the central corneal thickness (CCT), apical corneal thickness (ACT), and the thickness at four peripheral areas of the cornea were measured using Pentacam. Of the 3851 selected samples, after applying the exclusion criteria, the analysis was done on data from 2681 people. The mean age of the participants was 36.03&#xB1;18.51 years, ranging from 6 to 90 years, and 58.1% of them were female. Mean CCT and ACT were 533.87 &#x3BC;m (95%CI: 532.05 -535.69) and 536.72 &#x3BC;m (95%CI: 534.9 -538.54), respectively. Mean peripheral corneal thickness was 637.46 &#x3BC;m (95%CI: 635.09 -639.83) in the superior quadrant, and 594.34 &#x3BC;m (95%CI: 592.2 -596.47), 620.81 &#x3BC;m (95%CI: 618.66 -622.97), and 584.55 &#x3BC;m (95%CI: 582.18 -586.93) in the inferior, nasal, and temporal quadrants, respectively. Linear regression analysis showed significant associations between CCT and gender (P=0.001), age (P&lt;0.001), geographical location of residence (P&lt;0.001), the radius of corneal curvature (P&lt;0.001), anterior chamber depth (P&lt;0.001), and corneal volume (P&lt;0.001). This study is one of the few studies describing the distribution of the corneal thickness in a population of over 5-year-olds using Pentacam. Gender, anterior chamber depth, and corneal radius of curvature are some of the factors associated with CCT.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6676</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6676/5091</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>5</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>05</Month>
        <Day>20</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Association of Food Allergies, Cow&#x2019;s Milk Allergy, and Asthma With Pediatric Inflammatory Bowel Disease</title>
    <FirstPage>329</FirstPage>
    <LastPage>333</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Gholam-Hossein</FirstName>
        <LastName>Fallahi</LastName>
        <affiliation locale="en_US">Research Center for Pediatric Gastroenterology and Hepatology, Children&#x2019;s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Gholam-Reza</FirstName>
        <LastName>Khatami</LastName>
        <affiliation locale="en_US">Research Center for Pediatric Gastroenterology and Hepatology, Children&#x2019;s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Neda</FirstName>
        <LastName>Esmailzadehha</LastName>
        <affiliation locale="en_US">Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. AND Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mehri</FirstName>
        <LastName>Najafi</LastName>
        <affiliation locale="en_US">Research Center for Pediatric Gastroenterology and Hepatology, Children&#x2019;s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Fatemeh</FirstName>
        <LastName>Farahmand</LastName>
        <affiliation locale="en_US">Research Center for Pediatric Gastroenterology and Hepatology, Children&#x2019;s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Farzaneh</FirstName>
        <LastName>Motamed</LastName>
        <affiliation locale="en_US">Research Center for Pediatric Gastroenterology and Hepatology, Children&#x2019;s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Ahmad</FirstName>
        <LastName>Khodadad</LastName>
        <affiliation locale="en_US">Research Center for Pediatric Gastroenterology and Hepatology, Children&#x2019;s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Nima</FirstName>
        <LastName>Rezaei</LastName>
        <affiliation locale="en_US">Research Center for Immunodeficiencies, Children&#x2019;s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mohammad-Reza</FirstName>
        <LastName>Modarresi</LastName>
        <affiliation locale="en_US">Department of Pediatric Pulmonary Diseases, Tehran University of Medical Sciences, Tehran, Iran. AND Pediatric Respiratory Diseases Education and Research Network (PRDERN), Universal Scientific Education and Research Network (USERN), Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mostafa</FirstName>
        <LastName>Qorbani</LastName>
        <affiliation locale="en_US">Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Rita</FirstName>
        <LastName>Bagherian</LastName>
        <affiliation locale="en_US">Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.</affiliation>
      </Author>
    </AuthorList>
    <History>
      <PubDate PubStatus="received">
        <Year>2017</Year>
        <Month>07</Month>
        <Day>29</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2017</Year>
        <Month>12</Month>
        <Day>18</Day>
      </PubDate>
    </History>
    <abstract locale="en_US">There are controversies on the association of childhood allergic diseases with inflammatory bowel diseases (IBD). The aim of this study was to examine the association between food allergy, cow&#x2019;s milk allergy (CMA), and asthma with pediatric IBD in Iranian population. This case-control study was conducted on 200 individuals less than 18-year-old (100 with IBD and 100 as control group). Medical records, clinical presentation, and laboratory and para-clinical findings related to food allergy, CMA, and asthma were reviewed for all participants in both groups and were recorded. Among 100 children with IBD, 40 had Crohn's disease, and 60 had ulcerative colitis. The frequency of food allergy, cow's milk allergy, and asthma in children with IBD was significantly higher than the control group (P&lt;0.001). Asthma in children with Crohn's disease was significantly more prevalent than children with ulcerative colitis (P=0.008). Food allergy (OR: 22.1, 95% CI: 5.1-95.05, P&lt;0.001), CMA (OR: 15, 95% CI: 3-67, P&lt;0.001), and asthma (OR: 10, 95% CI: 3-37.05, P&lt;0.001) were significantly associated with increased risk of IBD in children. Food allergy, CMA in infancy and asthma are more prevalent in children with different subtypes of IBD. The diagnosis of these risk factors is associated with increased risk of Crohn's disease and ulcerative colitis.</abstract>
    <web_url>https://acta.tums.ac.ir/index.php/acta/article/view/6620</web_url>
    <pdf_url>https://acta.tums.ac.ir/index.php/acta/article/download/6620/5097</pdf_url>
  </Article>
  <Article>
    <Journal>
      <PublisherName>Tehran University of Medical Sciences</PublisherName>
      <JournalTitle>Acta Medica Iranica</JournalTitle>
      <Issn>0044-6025</Issn>
      <Volume>56</Volume>
      <Issue>5</Issue>
      <PubDate PubStatus="epublish">
        <Year>2018</Year>
        <Month>05</Month>
        <Day>20</Day>
      </PubDate>
    </Journal>
    <title locale="en_US">Evaluating the Effect of Staple Line Reinforcement on Reducing the Complications of Laparoscopic Sleeve Gastrectomy: A Randomized Clinical Trial</title>
    <FirstPage>334</FirstPage>
    <LastPage>340</LastPage>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Nasser</FirstName>
        <LastName>Malekpour Alamdari</LastName>
        <affiliation locale="en_US">Department of General Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</affiliation>
      </Author>
      <Author>
        <FirstName>Mohammadreza</FirstName>
        <LastName>Abdolhoseini</LastName>
        <affiliation locale="en_US">Department of General Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</affiliation>
 