Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 575 580 Sadra Masali Dentist, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Rosa Miri Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Cancer Institute Pathology Lab, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Mojgan Alaeddini Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Shahroo Etemad-Moghadam Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Donia Sadri Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Fatemeh Shahsavari Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. 2019 05 06 2019 12 24 Despite the similarities between oral and esophageal squamous cell carcinomas (SCCs), the survival rate of this cancer is relatively low in the esophagus compared to the oral cavity. To our knowledge, mast cells and angiogenesis have not been simultaneously compared between oral and esophageal SCCs. However, they have been separately evaluated in each of these locations with conflicting results. Therefore, the aim of this study was to assess and compare mast cell count and microvessel density between SCCs of the esophagus and oral cavity. A total of 46 oral and esophageal SCCs (23 of each) were stained immunohistochemically and histochemically with CD31 and methylene blue, respectively. Statistical analysis was performed using t-test, one-way ANOVA, and Pearson correlation analysis. Microvessel density was significantly higher in oral compared to esophageal tumors (P=0.02). Conversely, esophageal SCCs showed significantly higher mast cell counts than that of oral neoplasms (P=0.04). Pearson correlation analysis showed no association between these two factors in either oral SCC (P=0.51) or esophageal SCC (P=0.34). A significant difference between mean mast cell count and microvessel density in oral and esophageal SCC may be related to inherent differences in the tissues of origin and might, to some extent, be responsible for the different biological behaviors of these cancers. https://acta.tums.ac.ir/index.php/acta/article/view/7860 https://acta.tums.ac.ir/index.php/acta/article/download/7860/5324

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 8414 8414 Hadi Rokni-Yazdi 1 Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imaging Medical Center, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahsa Ghajarzadeh Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Tehran, Iran. Amirhossein Givan Department of Infectious Diseases, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Javad Namavar Department of Infectious Diseases, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Sepehr Azizi Department of Infectious Diseases, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2020 04 22 2020 04 22 https://acta.tums.ac.ir/index.php/acta/article/view/8414 https://acta.tums.ac.ir/index.php/acta/article/download/8414/5334

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 581 585 Shahram Taheri Isfahan Kidney diseases research center/Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran. Ali Asghar Pilehvarian Department of Biology, Payame Noor University, Isfahan, Iran. Afsoon Emami Naeini Department of Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Fariba Kushki Department of Biology, Payame Noor University, Isfahan, Iran. Firouzeh Moeinzadeh Department of Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2019 11 23 2020 01 25 End-stage renal disease is a situation that predisposes the patients to cardiovascular disease, especially myocardial infarction (MI). A valuable biomarker for the diagnosis of this event is cardiac troponin. Although some asymptomatic patients show high plasma levels of cardiac troponin I, it is still the most sensitive variable in MI. All patients more than 18-year-old, on chronic ambulatory peritoneal dialysis (CAPD) for at least three months, and did not have a history of acute myocardial infarction or hospitalization for CVD during last month are included in a cross-sectional descriptive study. Troponin I serum level was measured by VIDAS Troponin I Ultra (TNIU) Assay.  Correlation between serum troponin level and cardiovascular risk factors are evaluated. In this study, 52% of patients were male. The mean cTnI level was 0.025±0.044 ng/mL, less than 0.11 ng/mL, and only five patients had cTnI level more than the laboratory threshold. The cut-off level of cTnI for diagnosing cardiovascular disease must be re-evaluated and maybe increase to 0.3 ng/mL. Indeed, the asymptomatic patient may need more close observation for cardiovascular disease. https://acta.tums.ac.ir/index.php/acta/article/view/8191 https://acta.tums.ac.ir/index.php/acta/article/download/8191/5325

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 586 591 Mohammad Hasan Nemati Department of Cardiovascular Surgery, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Hasan Badie Department of Cardiovascular Surgery, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Mansour Jannati Department of Cardiovascular Surgery, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. 2019 11 03 2020 01 25 Pharmacologic-conjugated-cardioplegia is one of the strategies against ischemia and reperfusion. The aim of this study was to investigate the impact of nitroglycerin on myocardial protection and postoperative outcomes. This was a case-control study performed on 91 patients undergoing coronary artery bypass grafting in Faghihi Hospital, Shiraz University of Medical Sciences. Patients were randomly divided into case and control groups. Trinitroglycerin Conjugated Cardioplegia on Myocardial Protection of Patients with Coronary Artery Bypass Grafting. As a result of nitroglycerin, the number of patients requiring inotrope administration was increased. No other significant alteration was observed between two groups in neither of ischemic features nor postoperative outcomes. In conclusion, nitroglycerin conjugated cardioplegia, with the condition of this study, demonstrated a negative inotrope requirement without improvement in myocardium protection. https://acta.tums.ac.ir/index.php/acta/article/view/8170 https://acta.tums.ac.ir/index.php/acta/article/download/8170/5326

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 592 597 Mahsa Banitalebi Department of Community and Family Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Anahita Babak Department of Community and Family Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Reza Rouzbahani Department of Community and Family Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Raziyeh Khalili Nejad Motlagh Provincial Health Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2019 09 24 2020 01 25 Dyslipidemia is an important cause of cardiovascular diseases with increasing rates among adult populations. Nutrition and physical activity are known to have an impact on degrees of dyslipidemia. In this article, we had a study on nutritional behaviors and physical activities among middle-aged adults with and without dyslipidemia. In this case-control study, 200 middle-aged adults were entered. One hundred adults with dyslipidemia and 100 normal adults were included in this study. Data regarding desirable or undesirable use of fruits, vegetables, dairy, saturated fatty acids, fast foods, carbonated drinks, and extra salt intake with every meal were collected. Intensity and duration of physical activities were also collected from our data bank and analyzed with SPSS software. Our results indicated that people with dyslipidemia had a significantly increased usage of fast foods and saturated fatty acids, while the normal population had increased usage of vegetables and dairy. There were also significantly increased in intensity, duration per day, and weekly days of physical activity in healthy groups. Logistic regression indicated that undesirable consumption of fast foods, dairy, fatty acids, vegetables, and undesirable physical activity increases the risks for dyslipidemia (OR=8.2, OR=16.2, OR=8.2, OR=18.3, and OR=25.3 respectively) (P<0.05). This article emphasizes the role of proper nutritional behaviors and higher physical activities in decreasing the risks of dyslipidemia, and we suggest that further preventive interventions could be made based on the results of our study. https://acta.tums.ac.ir/index.php/acta/article/view/8099 https://acta.tums.ac.ir/index.php/acta/article/download/8099/5327

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 598 604 Farzad Goli Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Reihaneh Yekta Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Carl Eduard Scheidt Department of Psychosomatic Medicine, School of Medicine, Albert Ludwigs University, Freiburg, Germany. Amirreza Boroumand Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Reza Johari Fard Department of Psychology, School of Humanities, Islamic Azad University, Ahvaz, Iran. Maryam Ghazizadeh-Hashemi Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Maryam Keyvanipour Department of Psychology, Faculty of Education Sciences and Psychology, Ferdowsi University of Mashhad, Mashhad, Iran. Hamid Afshar Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Mehdi Khabazkhoob Department of Basic Sciences, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2019 09 24 2020 01 25 The aim of this study was to investigate the effect of a bioenergy economy-based program on the intensity of symptoms and quality of life among patients with myofascial pain syndrome. To collect the data, a simple random sampling was used among the women patients with MPS referred from a neurological clinic in Mashhad. Fifteen patients were collected as an experimental group. The method consisted of a quasi-experimental method with a pre-test, post-test, and follow-ups in two and six months after the program. Data collection main materials included the McGill Pain Questionnaire (MPQ) and WHO Quality of Life -BREF Questionnaire (WHOQOL-BREF). Moreover, Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory were used to increase the quality of the research. The group underwent six sessions of bioenergy economy-based program. Data collected were analyzed using repeated-measures analysis of variance (ANOVA) to reach the aim of the study. The mean score of pain intensity and depression had a significant difference in the post-test and the two follow-ups with the pre-test. The mean score of the anxiety had a significant difference in the pre-test and post-test but not in the follow-ups. The mean score of quality of life did not have a significant difference in the pre-test, post-test, and follow-ups even in the sub-scales, but the mean score of the post-test and the follow-ups were higher than the pre-test. Bioenergy economy-based program caused a significant decrease in the pain intensity, depression, and anxiety in women patients with MPS and remained consistent in the two and six month’s follow-ups. Even in the quality of life, there was an improvement after the program, and although the fluctuation in the score, the mean score after six months was lower than before the program. To conclude, a bioenergy economy-based program can be an effective program in lowering the pain, depression, and anxiety and improving the quality of life in women patients with myofascial pain syndrome, and this remains consistent in the following six months. https://acta.tums.ac.ir/index.php/acta/article/view/8102 https://acta.tums.ac.ir/index.php/acta/article/download/8102/5328

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 605 613 Mohammad Kiani Feizabadi Department of Medical Education, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Amir Mahdi Mafakherian Department of Nano Chemistry, Tehran University of Science and Technology, Tehran, Iran. Ahmadreza Goudarzi Department of Radiology Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Shadi Asadzandi Department of Medical Library and Information Sciences, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. AND Virtual School, Center for Excellence in ELearning in Medical Education, Tehran University of Medical Sciences, Tehran, Iran. Mahshad Ahmadi Department of Medical Education, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Shoaleh Bigdeli Center for Educational Research in Medical Sciences (CERMS), Iran University of Medical Sciences, Tehran, Iran. AND Department of Medical Education, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. 2019 01 09 2019 12 01 Radiology gamification articles were examined to determine the purpose and effect of games on the target audience and to provide a basis for researchers who aim to develop a new gamification. The articles related to radiology gamification, games, and simulations were retrieved from databases, including ProQuest, Springer, Cochrane Library, Ovid, PubMed, Scopus, and Web of Science via electronic search. To assess the quality of the articles Prisma and CASP checklists were used. Finally, according to the inclusion criteria, the appropriate articles were selected. Among 6917 retrieved articles, only 13 articles were related to radiology gamification, two of which were related to the analysis of the effects of radiology gamification in different areas such as differential diagnosis, education, dental radiology, and the number of drugs taken for imaging. These studies show that radiology gamification is few, and there are different forms of gamification, including but not limited to board games, physical games, and video games. Furthermore, in designing an educational game, learner’s characteristics, educational goals, and developing educational content are major steps. https://acta.tums.ac.ir/index.php/acta/article/view/7680 https://acta.tums.ac.ir/index.php/acta/article/download/7680/5329

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 614 617 EN Amin Jahanbakhshi Department of Neurosurgery, Skull Base Research Center, Iran University of Medical Sciences, Tehran, Iran. Arash Fattahi Department of Neurosurgery, Neurosurgery Ward of 7tir Hospital, Iran University of Medical Sciences, Tehran, Iran. Masoumeh Najafi Department of Radiotherapy-Oncology, 7tir Hospital, Iran University of Medical Sciences, Tehran, Iran. 2019 01 19 2020 02 07 Idiopathic intracranial hypertension (IIH) is defined as increased cerebrospinal fluid (CSF) opening pressure and abnormal fundoscopy when other causes of increased intracranial pressure are ruled out. We present a patient with a primary diagnosis of IIH who had undergone a lumboperitoneal shunt. Later she was treated with shunt revision, anti-tuberculosis drugs, and intravenous immunoglobulin. Acute lymphoblastic leukemia (ALL) was diagnosed after bone marrow biopsy. The initial response to chemotherapy was promising. Careful history taking, avoidance of unnecessary repetition of diagnostic procedures, avoidance of a tunneled vision, and a strong clinical suspicion is important to see the hidden causes underlying a difficult case of pseudotumor cerebri. Acute lymphoblastic leukemia and carcinomatous meningitis should be sought in IIH patients with abnormal presentation and unusual response to the known treatments. https://acta.tums.ac.ir/index.php/acta/article/view/7704 https://acta.tums.ac.ir/index.php/acta/article/download/7704/5330

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 621 623 Mohd Saalim Oral Medicine and Radiology, Nair Hospital Dental College, Mumbai, India. Kaustubh Sansare Oral Medicine and Radiology, Nair Hospital Dental College, Mumbai, India. Freny Karjodkar Oral Medicine and Radiology, Nair Hospital Dental College, Mumbai, India. Bushra Rahman Pediatric and Preventive Dentistry, ITS Greater Noida UP, India. Sneha Sharma Oral Medicine and Radiology, Nair Hospital Dental College, Mumbai, India. 2019 10 06 2019 12 24 Paraneoplastic pemphigus (PNP) is an autoimmune vesiculo-bullous disease of skin and mucous membrane associated with benign and malignant neoplasm. Most common malignancies associated with PNP are hematologic and lymphomatoid. Association of oral PNP with squamous cell carcinoma of the pharynx is very scarce, very few cases are reported, and also the cases of PNP are usually refractory to the treatment mainly those associated with hematologic. Here we reported a case of oral paraneoplastic pemphigus with squamous cell carcinoma of the pharynx that resolved on its own after completion of treatment of pharyngeal squamous cell carcinoma. https://acta.tums.ac.ir/index.php/acta/article/view/8123 https://acta.tums.ac.ir/index.php/acta/article/download/8123/5332

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 618 620 Sara Mirzaeian Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mona Jafari Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Reza Jafarzadeh 2 Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Medical Genetic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2019 07 17 2019 11 04 Spontaneous ovarian hyperstimulation syndrome (OHSS) is an uncommon type of OHSS that is characterized by gastrointestinal symptoms and complications of accommodation of body fluids in third spaces in the absence of medical ovarian stimulations. This syndrome is mostly seen in multiple or molar pregnancies with an underlying medical condition such as hypothyroidism. Treatment of spontaneous OHSS depends on the patient’s clinical condition. Appropriate management will warrant a successful pregnancy. The aim of this report is to introduce a case of spontaneous ovarian hyperstimulation syndrome in second pregnancy of a healthy pregnant woman. The patient was a 8 weeks pregnant female who referred to gynecology and obstetrics clinic because of gradual abdominal distension, abdominal pain and nausea from one month ago. The patient didn't have any history of the specific predisposing factors of OHSS such as thyroid gland dysfunction or multiple pregnancies. Abdominal sonography showed enlarged ovaries with prominent follecules as well as free fluid in the entire abdomen. Elevated levels of HCG (312850 mlU/ml) and carcinoembryonic antigen (106 U/ml) were the remarkable laboratory findings. We successfully controlled the patient by conservative management and the size of ovaries returned back to normal by 17th weeks of gestation. On sonographic follow-ups, untill delivery, the patient was symptom-free and a healthy infant was born. While spontaneous OHSS is a rare and life-threatening condition, conservative management including albumin and anticoagulant administration as well as paracentesis of body third space fluids, will be a promising approach in the stable patients. https://acta.tums.ac.ir/index.php/acta/article/view/7994 https://acta.tums.ac.ir/index.php/acta/article/download/7994/5331

Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 57 10 2020 04 22 624 625 Samiyeh Kazemi Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farzaneh Pazandeh Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farin Soleimani Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Anoshirvan Kazemnejad Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Zahra Kiani Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Nasrin Azimi Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Tahereh Mokhtariyan Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2019 01 16 2020 02 07 No Abstract https://acta.tums.ac.ir/index.php/acta/article/view/7698 https://acta.tums.ac.ir/index.php/acta/article/download/7698/5333