Acta Medica Iranica 2000. 38(1):25-28.

A new approach for the induction of vitiligo in mice
Zehtab T, Rafieii Tehranie S, Yazdanparast R

Abstract


Tyrosinase has been recognized as a major autoantign in human vitiligo. Here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsified in complete Freund’s adjuvant in C57BL/6 mice. The onse of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. Our results confirm that tyrosinase is the causative autoantigen in the genesis of autoimmune vitiligo.

Keywords


Mushroom tyrosinase, Human vitiligo, Experimental autoimmune vitiligo,

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.