Acta Medica Iranica 2002. 40(1):29-32.

"An Iranian girl with benign recurrent intrahepatic cholestasis "
Kavehmanesh Z, Kosari F


This report presents an 11 year-old girl with benign recurrent cholestasis (BRIC) who developed episodes of severe jaundice and pruritus at the ages of 2.5 and 10 years. Each episode lasted for 3-4 months. The peak level of serum bilirubin reached 33-37 mg/dl.Liver function tests were all normal during the attack except for increased alkaline phosphatase and prolonged prothrombin time responsive to vitamin K injection. All laboratory tests were normal between attacks. Other causes of liver diseases and cholestatic disorders were excluded. Imaging studies performed during the second attack all were normal.So, diagnosis of BRIC should be kept in mind in pediatric patients with cholestasis.


Benign recurrent intrahepatic cholestasis, Cholestasis, Icterus,

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