An Evidence against the Effect of Chronic Cytomegalovirus Infection in Unstable Angina Pectoris

  • Seyed Mohammad Alavi Infectious and Tropical Diseases Research Center, Razi Hospital, Joundishapour University of Medical Sciences, Ahwaz, Iran.
  • Seyed Mohammad Hasan Adel Department of Cardiology, Joundishapour University of Medical Sciences, Ahwaz, Iran.
  • Ali Reza Rajabzadeh Infectious and Tropical Diseases Research Center, Razi Hospital, Joundishapour University of Medical Sciences, Ahwaz, Iran.
Keywords: Cytomegalovirus infections, Angina, unstable


Recent reports have suggested that cytomegalovirus (CMV) infection may contribute to risk of cardiovascular disease. However, relationship between CMV infection and unstable angina (UA) is controversial and studies about this subject in Iran and even region are lacking. The aim of this study was to determine whether unstable angina is related to seropositivity to chronic cytomegalovirus infection. We measured serum CMV IgG levels in a case control study participants in CCU in Razi Hospital, Ahvaz, Iran, from 2004 to 2005. Blood samples were drawn during study period from 96 patients (mean age 56 years) with UA according to American Heart Association Criteria and from 96 participants free of cardiovascular disease (mean age 58 years) and stored at -20°C. Blood samples of patients were undertaken for investigating the specific anti CMV-IgG by ELISA method. Data were analyzed in SPSS 11.5 by using chi square test, odds ratios (OR) with 95% confidence intervals (CI). Ninety three percent of patients with unstable angina and 96.7% in the control group presented a positive anti CMV-IgG. Odds ratio was 0.52 with95% CI: 0.10 to 2.42. There was no significant correlation between CMV-IgG positivity and unstable angina (P>0.05). There was also no differences in CMV-IgG positivity in clinical groups of UA (P>0.05). The relationship between seropositivity of CMV-IgG and unstable angina has been restituted by the results of this study. However, further population based cohort studies for relationship between CMV infection and coronary artery disease must be conducted.


Grabczewska Z, Nartowicz E. Infections with Chlamydia

pneumoniae, Helicobacter pylori or cytomegalovirus and

atherosclerosis. Przegl Lek 1999;56(9):584-7.

Muhlestein JB, Anderson JL. Chronic infection and

coronary artery disease. Cardiol Clin 2003;21(3):333-62.

Prasad A, Zhu J, Halcox JP, Waclawiw MA, Epstein SE,

Quyyumi AA. Predisposition to atherosclerosis by

infections: role of endothelial dysfunction. Circulation


Kol A, Sperti G, Shani J, Schulhoff N, van de Greef W,

Landini MP, La Placa M, Maseri A, Crea F.

Cytomegalovirus replication is not a cause of instability in

unstable angina. Circulation 1995;91(7):1910-3.

Borgia MC, Mandolini C, Barresi C, Battisti G, Carletti F,

Capobianchi MR. Further evidence against the implication

of active cytomegalovirus infection in vascular

atherosclerotic diseases. Atherosclerosis 2001;157(2):457-

Braunwald ZL. Braunwald's Heart Disease: A Textbook of

Cardiovascular Medicine. 6th ed. Philadelphia: WB

Saunders; 2001. p. 1232-4.

Bermejo García J, Martínez Martínez P, Martín Rodríguez

JF, de la Torre Carpente M, Bustamante Bustamante R,

Guerrero Peral AB, Ortiz de Lejarazu R, Eiros Bouza JM,

Blanco García S, Fernández-Avilés F. Inflammation and

infection in stable coronary disease and acute coronary

syndrome. Rev Esp Cardiol 2001;54(4):453-9.

Basinkevich AB, Shakhnovich RM, Martynova VR,

Kolkova NI, Rakovskaia IV, Karazhas NV, Evseeva LF,

Dobrovolskiĭ AB, Deev AD, Noeva EA, Ruda MIa. Role

of Chlamydia, mycoplasma and cytomegalovirus infection

in the development of coronary artery disease.

Kardiologiia 2003;43(11):4-9.

Timóteo A, Ferreira J, Paixão P, Aguiar C, Teles R,

Cardoso E, Silva JA, Marques T, Seabra-Gomes R.

Serologic markers for cytomegalovirus in acute coronary

syndromes. Rev Port Cardiol 2003;22(5):619-31.

Altannavch Ts, Roubalová K, Broz J, Hrubá D, Andĕl M.

Serological markers of Chlamydia pneumoniae,

cytomegalovirus and Helicobacter pylori infection in

diabetic and non-diabetic patients with unstable angina

pectoris. Cent Eur J Public Health 2003;11(2):102-6.

Gattone M, Iacoviello L, Colombo M, Castelnuovo AD,

Soffiantino F, Gramoni A, Picco D, Benedetta M,

Giannuzzi P. Chlamydia pneumoniae and cytomegalovirus

seropositivity, inflammatory markers, and the risk of

myocardial infarction at a young age. Am Heart J. 2001

Oct;142(4):633-40. Comment in: Am Heart J

;145(2):e9; author reply e10.

Danesh J, Wong Y, Ward M, Muir J. Chronic infection

with Helicobacter pylori, Chlamydia pneumoniae, or

cytomegalovirus: population based study of coronary heart

disease. Heart 1999;81(3):245-7.

Ossewaarde JM, Feskens EJ, De Vries A, Vallinga CE,

Kromhout D. Chlamydia pneumoniae is a risk factor for

coronary heart disease in symptom-free elderly men, but

Helicobacter pylori and cytomegalovirus are not.

Epidemiol Infect 1998;120(1):93-9.

Strachan DP, Carrington D, Mendall MA, Butland BK,

Sweetnam PM, Elwood PC. Cytomegalovirus

seropositivity and incident ischaemic heart disease in the

Caerphilly prospective heart disease study. Heart


How to Cite
Alavi SM, Adel SMH, Rajabzadeh AR. An Evidence against the Effect of Chronic Cytomegalovirus Infection in Unstable Angina Pectoris. Acta Med Iran. 49(2):78-80.